Diverse modes of gene action contribute to heterosis for quantitative disease resistance in maize [0.03%]
多种基因作用方式贡献于玉米对数量性状疾病抗性的杂种优势
Asher I Hudson,Maggie R Wagner,Shannon Sermons et al.
Asher I Hudson et al.
Disease resistance in plants can be conferred by single genes of large effect or by multiple genes each conferring incomplete resistance. The latter case, termed quantitative resistance, may be difficult for pathogens to overcome through ev...
A model of Hill-Robertson interference caused by purifying selection in a non-recombining genome [0.03%]
纯化选择引起的非重组基因组中Hill-Robertson干扰模型
Hannes Becher,Brian Charlesworth
Hannes Becher
A new approach to modeling the effects of Hill-Robertson interference on levels of adaptation and patterns of variability in a non-recombining genome or genomic region is described. The model assumes a set of L diallelic sites subject to re...
Qi Fan,Christopher Tran,Wei Cao et al.
Qi Fan et al.
Mediator is an evolutionarily conserved multiprotein complex that acts as a critical coregulator of RNA polymerase II-mediated transcription. While core Mediator components are broadly required for transcription, others govern specific regu...
Two eIF4E paralogs occupy separate germ granule mRNPs that mediate mRNA repression and translational activation [0.03%]
两个eIF4E同源物占据单独的生殖颗粒mRNPs，介导mRNA抑制和翻译激活
Gita Gajjar,Hayden P Huggins,Eun Suk Kim et al.
Gita Gajjar et al.
We studied translation factor eIF4E paralogs that regulate germline mRNAs. Translational control of mRNAs is essential for germ cell differentiation and embryogenesis. Messenger ribonucleoprotein (mRNP) complexes assemble on mRNAs in the nu...
Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA [0.03%]
拓扑异构酶I在核糖体DNA中的叉屏障独立作用
Temistocles Molinar Jr,Daniel Sultanov,Hannah Klein et al.
Temistocles Molinar Jr et al.
Topoisomerase I, a nickase that allows swiveling of the DNA substrate, is highly enriched in the ribosomal DNA (rDNA) from yeast to humans, but its function at this locus remains poorly understood. S. cerevisiae mutants lacking topoisomeras...
New perspectives on Drosophila melanogaster de novo gene origination revealed by investigation of ancient African genetic variation [0.03%]
对古老非洲遗传变异的研究揭示了对黑腹果蝇全新基因起源的新视角
Julie M Cridland,Elizabeth S Polston,David J Begun
Julie M Cridland
De novo genes can be defined as sequences producing evolutionarily derived transcripts that are not homologous to transcripts produced in an ancestor. While they appear to be taxonomically widespread, there is little agreement regarding the...
Human MeCP2 binds to promoters and inhibits transcription in an unmethylated yeast genome [0.03%]
人源MeCP2结合到启动子并在一个无甲基化的酵母基因组中抑制转录
Joshua A R Brown,Maggie Y M Ling,Juan Ausió et al.
Joshua A R Brown et al.
MeCP2 is a DNA-binding transcriptional regulator that is present at near-histone levels in mammalian cortical neurons. Originally identified as a DNA methylation reader, MeCP2 has been proposed to repress transcription by recruiting corepre...
Dynamic regulation of murine RNA Polymerase III transcription during heat shock stress [0.03%]
热休克应激过程中小鼠RNA聚合酶III转录的动态调控
Thomas F Nguyen,James Z J Kwan,Jennifer E Mitchell et al.
Thomas F Nguyen et al.
Cells respond to many different types of stresses by overhauling gene expression patterns, both at the transcriptional and translational level. Under heat stress, global transcription and translation are inhibited, while the expression of c...
A Theory of Heterosis [0.03%]
杂种优势理论
Zhao-Bang Zeng,Gabriel De Siqueira Gesteira,Lujia Mo et al.
Zhao-Bang Zeng et al.
Heterosis refers to the superior performance of a hybrid over its parents. It is the basis for hybrid breeding particularly for maize and rice. Genetically it is due to interactions between alleles of quantitative trait loci (QTL) (dominanc...
A novel genome-wide association study method for detecting quantitative trait loci interacting with complex population structures in plant genetics [0.03%]
植物遗传学中用于检测与复杂种群结构相互作用的定量性状位点的新全基因组关联研究方法
Kosuke Hamazaki,Hiroyoshi Iwata,Tristan Mary-Huard
Kosuke Hamazaki
In plant genetics, most modern association analyses are performed on panels that bring together individuals from several populations, including admixed individuals whose genomes comprise chromosomal regions from different populations. These...