Ivan Specht,Julia A Palacios
Ivan Specht
Bayesian inference of gene genealogies and evolutionary parameters from molecular sequences can provide key insights into the evolutionary history of populations. Existing tools, however, often scale poorly with sample size. We present inPh...
Dosage compensation of Caj1-induced cytotoxicity by Sis1 and Ydj1 reveals complex interactions among JDPs in the yeast cytosol [0.03%]
Sis1和Ydj1通过剂量补偿Caj1诱导的细胞毒性揭示酵母胞质中JDP之间的复杂相互作用
Preeti Sagarika,Dharani Krishnadas Kurup,Anjitha Gireesh et al.
Preeti Sagarika et al.
Cellular proteostasis depends on tightly regulated Hsp70-J-domain protein (JDP) networks that coordinate protein folding and degradation. Here, we define a previously unrecognized role for the budding yeast JDP Caj1 in modulating nucleocyto...
Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades [0.03%]
校准并记录两种密切相关沃尔巴克氏体谱系的宿主转换和不相容位点的演化
J Dylan Shropshire,William R Conner,Dan Vanderpool et al.
J Dylan Shropshire et al.
Maternally inherited Wolbachia alphaproteobacteria are the most common arthropod endosymbionts. Often Wolbachia spread to high frequencies through cytoplasmic incompatibility, in which cif loci act through sperm to kill embryos lacking Wolb...
Multiplex organoid mutagenesis reveals gene combinations driving transformation, pathology and chemosensitivity in ovarian carcinoma [0.03%]
多重类器官诱变揭示卵巢癌发生、病理和化学敏感性的基因组合
Daryl J Phuong,Coulter Q Ralston,Tony M Ezzat et al.
Daryl J Phuong et al.
High-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Most tumors arise from the Fallopian tubal epithelium (TE), exhibit numerous mutations, and present heterogenous pathological feature...
The forkhead transcription factor FKH-7/FOXP acts in C. elegans chemosensory neurons to shape a life history strategy [0.03%]
叉头转录因子FKH-7/FOXP通过调节线虫化学感受神经元来影响动物寿命和繁殖力的取舍关系
Cynthia M Chai,Seth R Taylor,Carsten H Tischbirek et al.
Cynthia M Chai et al.
Some organisms exhibit a remarkable ability to adapt their life history strategies within a single lifespan in response to dynamic biotic and abiotic cues, such as Caenorhabditis elegans larval facultative diapause. However, the molecular b...
Identifying optimal sets of individuals under a pairwise genomic relationship threshold for breeding and conservation [0.03%]
在育种和保护下识别最优个体配对基因组关系阈值的方法
Milan Lstibůrek,Václav Bittner,Thomas Solvin et al.
Milan Lstibůrek et al.
Maximizing genetic response to selection while constraining inbreeding is a central challenge in breeding and conservation. Classic optimal contribution selection methods address this by managing average population coancestry. However, this...
The curious case of CCHamide1: a role for CCHamide1 in sleep, metabolism and fitness in Drosophila melanogaster [0.03%]
果蝇神经肽CCHamide1在睡眠、代谢和适应性中的作用
Swetha Gopalakrishnan,Anurag Nishad,Rimalu Regi et al.
Swetha Gopalakrishnan et al.
Circadian clocks regulate a myriad of physiological processes rhythmically throughout the day in most organisms. Our study focuses on a relatively less-studied neuropeptide CCHamide1 (CCHa1), expressed in the Drosophila melanogaster gut and...
Cell type specific allometry controls sex-differences in Drosophila organ size [0.03%]
性别特异性细胞几何学决定果蝇器官大小上限的区别调控机制
Soumitra Pal,Jerome Avellaneda,Celena M Cherian et al.
Soumitra Pal et al.
Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than males. While most organs are present acro...
Tobias Warnecke
Tobias Warnecke
For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scientists-always on the lookout for general principles-have categorized these mutations, hoping tha...
Distinct functions in fertility and patterns of paternal incorporation of the histone H2A variants HTAS-1 and HTZ-1 in C. elegans [0.03%]
秀丽线虫中组蛋白H2A变体HTAS-1和HTZ-1在生殖中的不同功能及其父本嵌合模式
Swadha Singh,Tomoko Tabuchi,Keiko Hokeness et al.
Swadha Singh et al.
As germ cells transform into sperm, the packaging of DNA is critical for transcriptional reprogramming and transmission of paternal genetic and epigenetic information vital for male fitness. Here we investigated the roles in Caenorhabditis ...