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Dosage compensation of Caj1-induced cytotoxicity by Sis1 and Ydj1 reveals complex interactions among JDPs in the yeast cytosol

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Cellular proteostasis depends on tightly regulated Hsp70-J-domain protein (JDP) networks that coordinate protein folding and degradation. Here, we define a previously unrecognized role for the budding yeast JDP Caj1 in modulating nucleocytoplasmic protein qual... ...