Altering enhancer-promoter linear distance impacts promoter competition in cis and in trans [0.03%]
增强子与启动子的线性距离变化会影响顺式和反式的启动子竞争
Jack R Bateman,Justine E Johnson
Jack R Bateman
In Drosophila, pairing of maternal and paternal homologs can permit trans-interactions between enhancers on one homolog and promoters on another, an example of a phenomenon called transvection. When chromosomes are paired, promoters in cis ...
Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genes [0.03%]
本地适应与上位效应致使蛋白质编码基因的连锁不平衡呈现出不同模式
Aaron P Ragsdale
Aaron P Ragsdale
Selected mutations interfere and interact with evolutionary processes at nearby loci, distorting allele frequency trajectories and creating correlations between pairs of mutations. Recent studies have used patterns of linkage disequilibrium...
FMRP-dependent production of large dosage-sensitive proteins is highly conserved [0.03%]
FMRP依赖的大剂量敏感型蛋白质的产生是高度保守的
Keegan Flanagan,Alireza Baradaran-Heravi,Qi Yin et al.
Keegan Flanagan et al.
Mutations in FMR1 are the most common heritable cause of autism spectrum disorder. FMR1 encodes an RNA-binding protein, FMRP, which binds to long, autism-relevant transcripts and is essential for normal neuronal and ovarian development. In ...
Interactions of Caenorhabditis elegans β-tubulins with the microtubule inhibitor and anthelmintic drug albendazole [0.03%]
芽丝虫素β-管蛋白与微管抑制剂和驱虫药物奥苯达唑的相互作用
Linda M Pallotto,Clayton M Dilks,Ye-Jean Park et al.
Linda M Pallotto et al.
Parasitic nematodes are major human and agricultural pests, and benzimidazoles are amongst the most important broad-spectrum anthelmintic drug class used for their control. Benzimidazole resistance is now widespread in many species of paras...
Statistical analysis of spatially resolved transcriptomic data by incorporating multiomics auxiliary information [0.03%]
结合多组学辅助信息的空间转录组数据分析
Yan Li,Xiang Zhou,Hongyuan Cao
Yan Li
Effective control of false discovery rate is key for multiplicity problems. Here, we consider incorporating informative covariates from external datasets in the multiple testing procedure to boost statistical power while maintaining false d...
TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies [0.03%]
双生子基因组关联研究中的eQTL和GWAS的超快且强大的关联分析工具-TwinEQTL
Kai Xia,Andrey A Shabalin,Zhaoyu Yin et al.
Kai Xia et al.
We develop a computationally efficient alternative, TwinEQTL, to a linear mixed-effects model for twin genome-wide association study data. Instead of analyzing all twin samples together with linear mixed-effects model, TwinEQTL first splits...
Meta-Analysis
Genetics. 2022 Jul 30;221(4):iyac088. DOI:10.1093/genetics/iyac088 2022
Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes [0.03%]
错配修复和核糖核苷酸还原酶突变体的复杂突变谱型揭示了MutS同源物（MSH）复合物的新修复底物特异性
Natalie A Lamb,Jonathan E Bard,Raphael Loll-Krippleber et al.
Natalie A Lamb et al.
Determining mutation signatures is standard for understanding the etiology of human tumors and informing cancer treatment. Multiple determinants of DNA replication fidelity prevent mutagenesis that leads to carcinogenesis, including the reg...
A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase [0.03%]
甲硫氨酸活化抑制因子Coa4通过线粒体铜递送途径参与细胞色素c氧化酶的生物生成
Abhinav B Swaminathan,Shivatheja Soma,Alison C Vicary et al.
Abhinav B Swaminathan et al.
Cytochrome c oxidase (CcO) is a multimeric copper-containing enzyme of the mitochondrial respiratory chain that powers cellular energy production. The two core subunits of cytochrome c oxidase, Cox1 and Cox2, harbor the catalytic CuB and Cu...
APOK3, a pollen killer antidote in Arabidopsis thaliana [0.03%]
拟南芥中的雄配子体特异性致死基因APOK3及其反向救援基因RDSP1的克隆与功能分析
Matthieu Simon,Stéphanie Durand,Anthony Ricou et al.
Matthieu Simon et al.
The principles of heredity state that the two alleles carried by a heterozygote are equally transmitted to the progeny. However, genomic regions that escape this rule have been reported in many organisms. It is notably the case of genetic l...
Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain [0.03%]
结合GWAS和TWAS识别玉米籽粒生育酚含量候选因果基因
Di Wu,Xiaowei Li,Ryokei Tanaka et al.
Di Wu et al.
Tocochromanols (tocopherols and tocotrienols, collectively vitamin E) are lipid-soluble antioxidants important for both plant fitness and human health. The main dietary sources of vitamin E are seed oils that often accumulate high levels of...