Estimating linkage disequilibrium and selection from allele frequency trajectories [0.03%]
从等位基因频率变化轨迹估算连锁不平衡和选择压力
Yunxiao Li,John P Barton
Yunxiao Li
Genetic sequences collected over time provide an exciting opportunity to study natural selection. In such studies, it is important to account for linkage disequilibrium to accurately measure selection and to distinguish between selection an...
Saccharomyces genome database update: server architecture, pan-genome nomenclature, and external resources [0.03%]
酵母基因组数据库更新：服务器构架，泛基因命名法及外部资源
Edith D Wong,Stuart R Miyasato,Suzi Aleksander et al.
Edith D Wong et al.
As one of the first model organism knowledgebases, Saccharomyces Genome Database (SGD) has been supporting the scientific research community since 1993. As technologies and research evolve, so does SGD: from updates in software architecture...
The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility [0.03%]
基质细胞因子Drosophila Cellular Communication Network Factor 是突触传递和女性生育力所必需的
Elizabeth Catudio Garrett,Ashley M Bielawski,Evelyne Ruchti et al.
Elizabeth Catudio Garrett et al.
Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular comm...
Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response [0.03%]
幻影盘生长因子是果蝇壳多糖酶样蛋白，在形态发生和二氧化碳反应中发挥作用
Anne E Sustar,Liesl G Strand,Sandra G Zimmerman et al.
Anne E Sustar et al.
Chitinase-like proteins (CLPs) are members of the family 18 glycosyl hydrolases, which include chitinases and the enzymatically inactive CLPs. A mutation in the enzyme's catalytic site, conserved in vertebrates and invertebrates, allowed CL...
wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background [0.03%]
在nid-1突变体背景下，wrk-1和rig-5控制Caenorhabditis elegans腹神经索中先驱轴突和跟随轴突的导航
Abigail H Feresten,Jaffar M Bhat,Alex J Yu et al.
Abigail H Feresten et al.
During nervous system development, neurons send out axons, which must navigate large distances to reach synaptic targets. Axons grow out sequentially. The early outgrowing axons, pioneers, must integrate information from various guidance cu...
Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones [0.03%]
野生型酵母的端粒比 domesticate 型的要短
Melania D&#x;Angiolo,Jia-Xing Yue,Matteo De Chiara et al.
Melania D&#x;Angiolo et al.
Telomeres are ribonucleoproteins that cap chromosome-ends and their DNA length is controlled by counteracting elongation and shortening processes. The budding yeast Saccharomyces cerevisiae has been a leading model to study telomere DNA len...
Danat Yermakovich,Vasili Pankratov,Urmo Võsa et al.
Danat Yermakovich et al.
The admixture between modern humans and Neandertals has resulted in ∼2% of the genomes of present-day non-Africans being composed of Neandertal DNA. Introgressed Neandertal DNA has been demonstrated to significantly affect the transcriptom...
Mega-scale Bayesian regression methods for genome-wide prediction and association studies with thousands of traits [0.03%]
大规模贝叶斯回归方法用于具有数千种性状的基因组预测和关联研究
Jiayi Qu,Daniel Runcie,Hao Cheng
Jiayi Qu
Large-scale phenotype data are expected to increase the accuracy of genome-wide prediction and the power of genome-wide association analyses. However, genomic analyses of high-dimensional, highly correlated traits are challenging. We develo...
A flexible RecC surface loop required for Chi hotspot control of RecBCD enzyme [0.03%]
RecBCD酶Chi热点控制所需的柔性RecC表面环路
Susan K Amundsen,Alex Richardson,Khoi Ha et al.
Susan K Amundsen et al.
Escherichia coli RecBCD helicase-nuclease promotes vital homologous recombination-based repair of DNA double-strand breaks. The RecB nuclease domain (Nuc) is connected to the RecB helicase domain by a 19-amino-acid tether. When DNA binds to...
Mitotic progression and dual spindle formation caused by spindle association of de novo-formed microtubule-organizing centers in parthenogenetic embryos of Drosophila ananassae [0.03%]
成熟分裂推进及由新形成的微管组织中心引起的双纺锤体的形成发生在不解合子果蝇胚胎中
Kazuyuki Hirai,Yoshihiro H Inoue,Muneo Matsuda
Kazuyuki Hirai
Facultative parthenogenesis occurs in many animal species that typically undergo sexual reproduction. In Drosophila, such development from unfertilized eggs involves diploidization after completion of meiosis, but the exact mechanism remain...