Blair K Schneider,Shixiang Sun,Moonsook Lee et al.
Blair K Schneider et al.
Retrotransposons are a class of transposable elements capable of self-replication and insertion into new genomic locations. Across species, the mobilization of retrotransposons in somatic cells has been suggested to contribute to the cell a...
Rapid generation of Caenorhabditis elegans single-copy transgenes combining recombination-mediated cassette exchange and drug selection [0.03%]
结合重组介导的磁带交换和药物筛选快速生成秀丽隐杆线虫单拷贝转基因系统
Michael L Nonet
Michael L Nonet
I outline a streamlined method to insert large, single-copy transgenes into the Caenorhabditis elegans genome using recombination-mediated cassette exchange (RMCE) that relies solely on drug selection yielding a homozygous fluorescent prote...
A rarefaction approach for measuring population differences in rare and common variation [0.03%]
一种测量稀有和常见变异的群体差异的罕见faction方法
Daniel J Cotter,Elyssa F Hofgard,John Novembre et al.
Daniel J Cotter et al.
In studying allele-frequency variation across populations, it is often convenient to classify an allelic type as "rare," with nonzero frequency less than or equal to a specified threshold, "common," with a frequency above the threshold, or ...
A novel ubiquitin-proteasome system regulation of Sgf73/ataxin-7 that maintains the integrity of the coactivator SAGA in orchestrating transcription [0.03%]
一种新颖的泛素-蛋白酶体系统调节Sgf73 / Ataxin-7以维持协同激活子SAGA的完整性的机制，以协调转录
Priyanka Barman,Amala Kaja,Pritam Chakraborty et al.
Priyanka Barman et al.
Ataxin-7 maintains the integrity of Spt-Ada-Gcn5-Acetyltransferase (SAGA), an evolutionarily conserved coactivator in stimulating preinitiation complex (PIC) formation for transcription initiation, and thus, its upregulation or downregulati...
Genomic determination of breeding systems and trans-specific evolution of HD MAT genes in suilloid fungi [0.03%]
棒孢属真菌基因组水平繁殖方式鉴定及其HD-MAT基因跨物种进化分析
Yi-Hong Ke,Sara Branco,Anna L Bazzicalupo et al.
Yi-Hong Ke et al.
Studying the signatures of evolution can help to understand genetic processes. Here, we demonstrate how the existence of balancing selection can be used to identify the breeding systems of fungi from genomic data. The breeding systems of fu...
Correlated stabilizing selection shapes the topology of gene regulatory networks [0.03%]
相关稳定选择造就基因调控网络的拓扑结构
Apolline J R Petit,Jeremy Guez,Arnaud Le Rouzic
Apolline J R Petit
The evolution of gene expression is constrained by the topology of gene regulatory networks, as co-expressed genes are likely to have their expressions affected together by mutations. Conversely, co-expression can also be an advantage when ...
This population does not exist: learning the distribution of evolutionary histories with generative adversarial networks [0.03%]
不存在的种群：用生成对抗网络学习进化史分布
William W Booker,Dylan D Ray,Daniel R Schrider
William W Booker
Numerous studies over the last decade have demonstrated the utility of machine learning methods when applied to population genetic tasks. More recent studies show the potential of deep-learning methods in particular, which allow researchers...
A Twist-Box domain of the C. elegans Twist homolog, HLH-8, plays a complex role in transcriptional regulation [0.03%]
C. elegen Twist同源物HLH-8的Twist盒结构域在其转录调控中发挥复杂的作用
Michael J Gruss,Colleen O&#x;Callaghan,Molly Donnellan et al.
Michael J Gruss et al.
TWIST1 is a basic helix-loop-helix (bHLH) transcription factor in humans that functions in mesoderm differentiation. TWIST1 primarily regulates genes as a transcriptional repressor often through TWIST-Box domain-mediated protein-protein int...
Three recent sex chromosome-to-autosome fusions in a Drosophila virilis strain with high satellite DNA content [0.03%]
富含卫星DNA的Drosophila virilis品系中的三个最近性染色体-常染色体融合事件
Jullien M Flynn,Kevin B Hu,Andrew G Clark
Jullien M Flynn
The karyotype, or number and arrangement of chromosomes, has varying levels of stability across both evolution and disease. Karyotype changes often originate from DNA breaks near the centromeres of chromosomes, which generally contain long ...
Dispersal inference from population genetic variation using a convolutional neural network [0.03%]
利用卷积神经网络从群体遗传多态性中推断物种传播过程
Chris C R Smith,Silas Tittes,Peter L Ralph et al.
Chris C R Smith et al.
The geographic nature of biological dispersal shapes patterns of genetic variation over landscapes, making it possible to infer properties of dispersal from genetic variation data. Here, we present an inference tool that uses geographically...