On the number of genealogical ancestors tracing to the source groups of an admixed population [0.03%]
溯源 admixed 人群的谱系祖先数量
Jazlyn A Mooney,Lily Agranat-Tamir,Jonathan K Pritchard et al.
Jazlyn A Mooney et al.
Members of genetically admixed populations possess ancestry from multiple source groups, and studies of human genetic admixture frequently estimate ancestry components corresponding to fractions of individual genomes that trace to specific ...
Recombination and sterility in inversion homo- and heterokaryotypes under a general counting model of chiasma interference [0.03%]
交叉互换干扰的一般计数模型下的倒位纯合子和杂合子的重组与不育性分析
Øystein Kapperud
Øystein Kapperud
It has long been known that the chiasmata are not independently distributed in most organisms, a phenomenon known as chiasma interference. In this paper, I suggest a model of chiasma interference that generalizes the Poisson model, the coun...
Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression [0.03%]
纵向疾病进展研究中多种性状直接和/或间接遗传关联的特征分析
Myriam Brossard,Andrew D Paterson,Osvaldo Espin-Garcia et al.
Myriam Brossard et al.
When quantitative longitudinal traits are risk factors for disease progression and subject to random biological variation, joint model analysis of time-to-event and longitudinal traits can effectively identify direct and/or indirect genetic...
In vivo characterization of the maturation steps of a pigment dispersing factor neuropeptide precursor in the Drosophila circadian pacemaker neurons [0.03%]
拟南芥生物钟神经元中色素弥散因子神经肽前体的成熟过程的体内特征研究
Gyunghee G Lee,Kevin Zeng,Cole M Duffy et al.
Gyunghee G Lee et al.
Pigment dispersing factor (PDF) is a key signaling molecule coordinating the neuronal network associated with the circadian rhythms in Drosophila. The precursor (proPDF) of the mature PDF (mPDF) consists of 2 motifs, a larger PDF-associated...
Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast [0.03%]
物种特异性蛋白质-蛋白质相互作用决定了酵母中20S蛋白酶体的人源化
Sarmin Sultana,Mudabir Abdullah,Jianhui Li et al.
Sarmin Sultana et al.
Yeast and humans share thousands of genes despite a billion years of evolutionary divergence. While many human genes can functionally replace their yeast counterparts, nearly half of the tested shared genes cannot. For example, most yeast p...
The effects of inversion polymorphisms on patterns of neutral genetic diversity [0.03%]
倒位多态对中性遗传多样性模式的影响
Brian Charlesworth
Brian Charlesworth
The strong reduction in the frequency of recombination in heterozygotes for an inversion and a standard gene arrangement causes the arrangements to become partially isolated genetically, resulting in sequence divergence between them and cha...
Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants [0.03%]
罕见编码变异的不完全外显的潜在机制的基因调控作用下的信使rna剪接
Jonah Einson,Dafni Glinos,Eric Boerwinkle et al.
Jonah Einson et al.
Exonic variants present some of the strongest links between genotype and phenotype. However, these variants can have significant inter-individual pathogenicity differences, known as variable penetrance. In this study, we propose a model whe...
Dosage-sensitivity shapes how genes transcriptionally respond to allopolyploidy and homoeologous exchange in resynthesized Brassica napus [0.03%]
剂量敏感性决定了剂量敏感性塑造了基因在油菜甘蓝人工合成 allotetraploid中的转录响应及同源交换
Kevin A Bird,J Chris Pires,Robert VanBuren et al.
Kevin A Bird et al.
The gene balance hypothesis proposes that selection acts on the dosage (i.e. copy number) of genes within dosage-sensitive portions of networks, pathways, and protein complexes to maintain balanced stoichiometry of interacting proteins, bec...
A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster [0.03%]
一个新的EZH1错义突变与发育迟缓有关，在果蝇中表现出功能缺陷
Sharayu V Jangam,Lauren C Briere,Kristy L Jay et al.
Sharayu V Jangam et al.
EZH1, a polycomb repressive complex-2 component, is involved in a myriad of cellular processes. EZH1 represses transcription of downstream target genes through histone 3 lysine27 (H3K27) trimethylation (H3K27me3). Genetic variants in histon...
Permissiveness and competition within and between Neurospora crassa syncytia [0.03%]
链孢霉同步体内的宽容性和竞争性
Alexander P Mela,N Louise Glass
Alexander P Mela
A multinucleate syncytium is a common growth form in filamentous fungi. Comprehensive functions of the syncytial state remain unknown, but it likely allows for a wide range of adaptations to enable filamentous fungi to coordinate growth, re...