A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster
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EZH1, a polycomb repressive complex-2 component, is involved in a myriad of cellular processes. EZH1 represses transcription of downstream target genes through histone 3 lysine27 (H3K27) trimethylation (H3K27me3). Genetic variants in histone modifiers have bee... ...
