Mount Fuji's stubby peak: the genotypic density of additive landscapes near maximal fitness [0.03%]
富士山的残缺顶峰：接近最高适应度时累加式适应度地形的等位基因频率分布形状研究
Justin B Kinney
Justin B Kinney
Additive fitness landscapes-also called Mount Fuji landscapes-are the simplest and most widely used models of sequence-function relationships. As such, they play essential roles across multiple areas of biology, including evolutionary theor...
A long non-coding RNA regulates in vitro and in vivo triazole antifungal susceptibility in Aspergillus fumigatus [0.03%]
一个长链非编码RNA通过体外及体内机制调节烟曲霉对三唑类抗真菌药物的敏感性
Nava Raj Poudyal,Ryan T Mehlem,Priyanka Doneparthi et al.
Nava Raj Poudyal et al.
Azole-resistant Aspergillus infections are a source of increasing concern with limited alternative therapeutic options. However, as most infections are still caused by azole-susceptible Aspergillus strains, there is a need to better underst...
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes [0.03%]
recessive 疾病基因的等位基因频率主要由杂合子的多效性决定
Jonathan Judd,Jeffrey P Spence,Nikhil Milind et al.
Jonathan Judd et al.
The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency of deleterious variants, mutation rate, ...
Nutrient-responsive and DAF-16/FoxO target H1 histone HIL-1 promotes resistance to starvation and bacterial pathogens in Caenorhabditis elegans [0.03%]
营养响应基因、DAF-16/FoxO作用靶点H1组蛋白HIL-1促进秀丽隐杆线虫抵抗饥饿和细菌病原体感染
Kinsey Fisher,Rojin Chitrakar,L Ryan Baugh
Kinsey Fisher
Insulin/IGF-1 signaling (IIS) mediates metabolic and developmental acclimation to stressful conditions including starvation. The transcription factor DAF-16/FoxO actuates many of the physiological effects of reduced IIS, yet the specific co...
Transcriptional feedback targeting Wnt pathway components reveals hidden heterogeneity in C. elegans seam cell lineages [0.03%]
转录反馈作用于Wnt通路成分揭示了秀丽隐杆线虫 seam 干细胞系中的隐藏异质性
Mar Ferrando-Marco,Simon Berger,Michalis Barkoulas
Mar Ferrando-Marco
Asymmetric cell division in the epidermal stem cells of Caenorhabditis elegans, known as seam cells, relies on the Wnt/β-catenin asymmetry pathway to generate daughter cells with distinct fates. However, whether components of this pathway ...
A second life [0.03%]
第二人生
Irini Topalidou
Irini Topalidou
The Genetics Society of America Mentorship Award recognizes members of the scientific community for exceptional mentoring of geneticists at any career stage. Irini Topalidou is the inaugural recipient in the nonfaculty category, honored for...
Sex differences in transcription-associated mutagenesis in the human germline [0.03%]
人类生殖细胞转录相关突变的性别差异
Minyoung J Wyman,Ipsita Agarwal,Marc de Manuel et al.
Minyoung J Wyman et al.
In humans, germline mutation rates are three- to four-fold higher in males than females, for largely unknown reasons. We investigated whether transcription, a well-documented source of both DNA damage and repair in somatic tissues, is assoc...
Lethal effects of a hyperactive dGTP triphosphohydrolase in E. coli [0.03%]
Ecoli中dGTP三磷酸水解酶活性过高的致死效应
Niketa Bhawsinghka,Katie F Glenn,Bradley P Klemm et al.
Niketa Bhawsinghka et al.
E. coli possesses a unique class of dNTPases, known as deoxyguanosine triphosphohydrolase (dGTPase), which hydrolyses the DNA precursor dGTP into deoxyguanosine and tripolyphosphate. The enzyme has a fidelity role, as deletion of the encodi...
A single non-coding RNA locus produces small and long regulatory RNAs with distinct biological functions [0.03%]
一个非编码RNA位点产生具有不同生物学功能的小RNAs和长调控性RNA
Travis D Carney,Halyna R Shcherbata
Travis D Carney
The impact of non-coding RNAs on stem cell biology and differentiation processes is an important and incompletely understood area of research. Using the testes of Drosophila melanogaster as a proven model for investigating these processes, ...
Benchmarking Genomic Variant Calling Tools in Inbred Mouse Strains: Recommendations and Considerations [0.03%]
近交品系小鼠基因组变异检测工具的评估：建议与考量
Alexis Garretson,Laura Blanco-Berdugo,Aleisha Roberts et al.
Alexis Garretson et al.
With the growing affordability of whole-genome sequencing, variant identification has become an increasingly common task in modern genomics. In recent years, the number of software packages available for variant calling has rapidly increase...