MutSgamma promotes meiotic recombination and homolog pairing in mouse spermatocytes [0.03%]
MutSγ促进小鼠精母细胞的重组和同源配对
Melissa Frasca,Lakshmi Paniker,Rhea Kang et al.
Melissa Frasca et al.
DNA repair by homologous recombination is required for parental chromosomes (homologs) to accurately segregate during mammalian meiosis. Meiotic recombination promotes but also relies upon pairing between homologs. This mutual dependence an...
Remus Stana,Uri Ben-David,Daniel B Weissman et al.
Remus Stana et al.
Evolutionary rescue occurs when a population, facing a sudden environmental change that would otherwise lead to extinction, adapts through beneficial mutations, allowing it to recover and persist. A prime example of evolutionary rescue is t...
Jinguo Huang,Nicole Kleman,Saonli Basu et al.
Jinguo Huang et al.
SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of heritability (h), being equal to it if all causal variants are genotyped. Despite the simple int...
Quantitative Resolution of Cell Fate in the Early Embryogenesis of Caenorhabditis elegans [0.03%]
定量解析秀丽隐杆线虫早期胚胎发生过程中的细胞命运决议过程
Ruiqi Xiong,Yang Su,Mengchao Yao et al.
Ruiqi Xiong et al.
The nematode Caenorhabditis elegans exhibits an invariant cell lineage during its development, where the gene-molecular network that regulates the development is crucial for the biological process. While there are many molecular cell atlase...
A rapid accurate approach to inferring pedigrees in endogamous populations [0.03%]
一种在近婚群体中快速准确推断谱系的新方法
Cole M Williams,Brooke A Scelza,Sarah D Slack et al.
Cole M Williams et al.
Accurate reconstruction of pedigrees from genetic data remains a challenging problem. Many relationship categories (e.g. half-sibships versus avuncular) can be difficult to distinguish without external information. Pedigree inference algori...
Sudhir Kumar
Sudhir Kumar
The George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers as a whole and led an exemplary research career. The 2025 awardee is Sudhir Kumar from Temple University, who has...
More than meets the eye: Mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects [0.03%]
别具慧眼：果蝇色素基因white的突变影响广泛，使表型和转录出现多种效应
April Rickle,Krittika Sudhakar,Alix Booms et al.
April Rickle et al.
The white gene, one of the most widely used genetic markers in Drosophila research, serves as a standard background mutation for transgene insertions and genetic manipulations. While its primary function involves eye pigmentation, mutations...
Genetic analysis of stress hormone levels in hair of healthy nursery pigs and their relationships with backtest responses [0.03%]
健康保育猪毛发中压力激素水平的基因组分析及其与背脂厚度的关系研究
Fazhir Kayondo,Hayder Al-Shanoon,Yolande M Seddon et al.
Fazhir Kayondo et al.
This study explored the genetics of the levels of stress hormones (cortisol, cortisone, DHEA, and DHEA-S) in hair of 863 clinically healthy Yorkshire x Landrace male pigs at ∼40 days of age and evaluated their potential as biomarkers of in...
Meghan J Brady,Anjali Gupta,Jonathan I Gent et al.
Meghan J Brady et al.
In maize, there are two meiotic drive systems that target large heterochromatic knobs composed of tandem repeats known as knob180 and TR-1. The first meiotic drive haplotype, Abnormal chromosome 10 (Ab10) confers strong meiotic drive (∼75%...