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Lethal effects of a hyperactive dGTP triphosphohydrolase in E. coli

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E. coli possesses a unique class of dNTPases, known as deoxyguanosine triphosphohydrolase (dGTPase), which hydrolyses the DNA precursor dGTP into deoxyguanosine and tripolyphosphate. The enzyme has a fidelity role, as deletion of the encoding dgt gene results ... ...