Development of single-chain C1q affinity chromatography-mass spectrometry for the glycoform-resolved characterization of low-affinity immunoglobulin G interactions [0.03%]
单链C1q亲和色谱-质谱法的发展，用于低亲和力免疫球蛋白G相互作用的糖基化形式解析特征研究
Steffen Lippold,Kelvin Chang,Mirjam Dürkoop et al.
Steffen Lippold et al.
The interaction between complement factor C1q and the Fc region of immunoglobulin G (IgG) antibodies is modulated by the conserved IgG glycosylation site at Asn 297 and is a critical determinant of complement-dependent cytotoxicity. However...
Biparatopic targeting of IL-23 enables dual-epitope engagement and enhanced neutralization potency [0.03%]
双表位靶向IL-23能够实现双重表位结合并增强中和效力
Ross Gauntlett,James Lodge,Joe Watson et al.
Ross Gauntlett et al.
Biparatopic antibodies (bpAbs) have two non-overlapping epitopes on a single antigen, offering a distinct therapeutic potential, yet their application to soluble cytokines remains underexplored. Herewithin, we engineered and characterized b...
Comparison of knockdown approaches for the generation of stable cell populations expressing afucosylated antibodies [0.03%]
用于生成表达无岩藻糖基化抗体的稳定细胞系的不同敲除方法比较研究
Maria Tsachaki,Andrew Samy,Mégane Peltret et al.
Maria Tsachaki et al.
Targeted silencing of cellular genes in cell lines stably expressing a secreted recombinant protein offers a flexible and convenient strategy for modulating product quality attributes. However, unlike genetic knockout of a cellular gene or ...
Comparative Study
mAbs. 2026 Dec;18(1):2684393. DOI:10.1080/19420862.2026.2684393 2026
Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B [0.03%]
靶向组织因子通路抑制剂治疗甲型和乙型血友病的全人源单克隆抗体马期太西玛布的研究与优化
Macy Jin,Sunita Hett,Reema Jasuja et al.
Macy Jin et al.
We report the discovery and optimization of marstacimab, a novel monoclonal antibody targeting tissue factor pathway inhibitor (TFPI), for the treatment of hemophilia A and B. Hybridoma and phage display approaches identified antibodies tha...
NMR detects clustering and ultra-weak excipient interactions governing monoclonal antibody viscosity in formulation-relevant conditions [0.03%]
利用核磁共振检测在与制剂相关的条件下影响单克隆抗体黏度的聚类和极弱辅剂相互作用
Liza Boëffard-Dosierre,Camille Dagallier,Géraldine Eudier et al.
Liza Boëffard-Dosierre et al.
High-concentration formulations of monoclonal antibodies (mAbs) are required for subcutaneous administration but are frequently challenging to develop due to elevated viscosity and colloidal instability. These properties are governed by mAb...
Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors [0.03%]
新型CD2导向协同刺激双特异性抗体与CD3T细胞衔接器联合治疗克服实体肿瘤治疗的局限性
Welbeck Danquah,Mélanie Pichery,Thomas Eden et al.
Welbeck Danquah et al.
CD3 T cell engagers (TCEs) have transformed hematologic oncology, but dose-liming toxicity and the absence of adequate costimulation have limited TCE success in solid tumors. Consequently, to date, only one classical TCE developed for solid...
Correction [0.03%]
改正方针
Published Erratum
mAbs. 2026 Dec;18(1):2686538. DOI:10.1080/19420862.2026.2686538 2026
Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations [0.03%]
高浓度抗体产品的皮下给药（二）：以患者为中心的商业呈现形式的制剂、设备选择和临床衔接策略
Indrajit Ghosh,Suyash Deodhar,Hiten Gutka et al.
Indrajit Ghosh et al.
The landscape of drug delivery is undergoing a transformative shift. As demand for large-volume subcutaneous (SC) biologics continues to surge, the race to develop smarter, patient-centered combination drug products has never been more urge...
One-step cleavage and purification: a bifunctional IdeS-Protein A fusion protein for on-column generation of antibody fragments [0.03%]
一步切割和纯化：用于柱上生成抗体片段的双功能IdeS-蛋白A融合蛋白
Tongsheng Zhang,Huayuan Liao,Chun-Bo Teng et al.
Tongsheng Zhang et al.
Conventional production of antibody fragments (e.g. Fab/F(ab')2, VHH/(VHH)2) involves sequential enzymatic cleavage and multi-step purification to remove Fc domains and residual enzymes, a process that is laborious and inefficient for small...
Generation of human sequence antibodies in OmniChicken against the highly conserved mammalian target BDNF using three distinct discovery workflows [0.03%]
三种不同发现工作流程在OmniChicken中针对高度保守的哺乳动物靶点BDNF生成人源序列抗体
Kathryn H Ching,Sinéad Keating,Baisen Zeng et al.
Kathryn H Ching et al.
Generation of antibodies against highly conserved mammalian targets remains a substantial challenge in the therapeutic antibody space. Naïve and synthetic libraries address this need through rounds of in vitro affinity maturation. In vivo ...