Dickkopf-3 (DKK3) and the Progression of Diabetic Kidney Disease in Primary Health Care [0.03%]
dickkopf-3(DKK3)与基层医疗中的糖尿病肾病进展的关系
Felix Keller,Stefan Schunk,Sara Denicolò et al.
Felix Keller et al.
Prediction of kidney function decline is challenging in patients with type 2 diabetes mellitus (T2DM). Urinary Dickkopf-3 (uDKK3), a profibrotic tubular protein, is a promising biomarker for detecting tubular injury and predicting the progr...
Deleterious Effects of a GAD65 Monoclonal Autoantibody on Islet Function [0.03%]
GAD65单克隆自身抗体对胰岛功能的不利影响
Christiane S Hampe,Varun Kamat,Caeley L Bryan et al.
Christiane S Hampe et al.
This study was undertaken to further investigate the ability of a monoclonal autoantibody to GAD65 from a patient with pre-type 1 diabetes to be deleterious to islet function. The study was designed to further characterize the effects, unde...
β-Cell Mass in Individuals With and Without Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass [0.03%]
胃旁路手术后有和无术后低血糖患者的β细胞质量研究
Sevilay Tokgöz,Laura N Deden,Adrianne Hofboer et al.
Sevilay Tokgöz et al.
The exact mechanism of postbariatric hypoglycemia (PBH) is unclear, but β-cell mass expansion is hypothesized to play a role. We used [68Ga]Ga-NODAGA-exendin-4 positron emission tomography/computed tomography (PET/CT) to determine β-cell ...
Regulatory Roles of IGF2R in Insulin Secretion and Adaptive β-Cell Proliferation [0.03%]
IGF2R在胰岛素分泌及适应性β细胞增殖中的调控作用
Jun Shirakawa,Dario F De Jesus,Takahiro Tsuno et al.
Jun Shirakawa et al.
Insulin-like growth factor-2 receptor (IGF2R), also known as cation-independent mannose-6-phosphate receptor, is localized in cytosolic vesicles and is unique in its ability to transport enzymes to the lysosome and to clear IGF2 from the ce...
Trem2+ Macrophages Alleviate Renal Tubule Lipid Accumulation and Ferroptosis in Diabetic Nephropathy by Repressing IL-1β-Mediated CD36 Expression [0.03%]
TREM2+巨噬细胞通过抑制IL-1β介导的CD36表达缓解糖尿病肾病中的肾小管脂质积累和铁死亡
Xue Wang,Jiayi Wan,Chao Wang et al.
Xue Wang et al.
The presence of macrophages surrounding lipotoxic tubular epithelial cells (TECs) is a hallmark of diabetic nephropathy (DN). Nevertheless, the mechanisms of communication between these cell types are not well understood. Previous studies h...
Novel Function of Osteoprotegerin in the Modulation of Glucose Metabolism in the Liver via mTORC1 [0.03%]
osteoprotegerin通过mTORC1调节肝脏糖代谢的新功能
Sheng Qiu,Xia Wang,Ke Li et al.
Sheng Qiu et al.
Methylation of the Opg promoter inhibits hepatic OPG expression in obese mice. Hepatic OPG regulates glucose metabolism and insulin sensitivity in obese mice. OPG regulates glucose metabolism through interaction with mammalian target of rap...
Genotype-Phenotype Discrepancies in Family Members With a Novel Glucokinase Mutation: Insights Into GCK-MODY and Its Interplay With Insulin Resistance [0.03%]
新型葡萄糖激酶突变家族成员的基因型与表型不一致：GCK-MODY及其与胰岛素抵抗相互作用的启示
Shuhui Ji,Hua Shu,Hongqiang Zhao et al.
Shuhui Ji et al.
Heterozygous inactivating mutations in the glucokinase (GCK) gene cause maturity-onset diabetes of the young (GCK-MODY). We identified a novel variant of uncertain significance in the GCK gene (c.77A>T, p.Q26L) in two family members exhibit...
Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition [0.03%]
联合减肥和锻炼训练可改变骨骼肌亚细胞脂质定位以及肌肉间脂肪组织的细胞组成
Karin Zemski Berry,Amanda Garfield,Katie L Whytock et al.
Karin Zemski Berry et al.
Subcellular lipid accumulation and intermuscular adipose tissue (IMAT) accumulation are associated with insulin resistance, but the impact of combined weight loss and exercise training on localization of lipids and IMAT cellular composition...
Predicting Sustained Benefit From Tirzepatide in SURPASS-4: Who Benefits and Why? [0.03%]
SURPASS-4研究： tirzepatide哪些患者可长期获益及原因探讨
Miroslava Varadinova,Robert Wagner
Miroslava Varadinova