Flt3L-Derived Antigen-Presenting Cell Transfer in Neonatal NOD Mice Reduces the Incidence of Type 1 Diabetes [0.03%]
新生NOD小鼠中由flt3l衍生的抗原呈递细胞转移减少了1型糖尿病的发生率
Stephanie Orozco,Nouf Aljobaily,Hayley M Reynolds et al.
Stephanie Orozco et al.
Neonatal transfer of immature dendritic cell-enriched Flt3L splenocytes significantly reduces the incidence of type 1 diabetes in female NOD mice. Early time points are associated with accumulation of anergic T cells. In adult mice, there i...
Lysyl Oxidase Promotes Actin-Dependent Neutrophil Activation and Cytotoxicity Toward Retinal Endothelial Cells in Diabetes [0.03%]
糖尿病中lysyl氧化酶促进肌动蛋白依赖的中性粒细胞活化和对视网膜内皮细胞的细胞毒作用
Mahesh Agarwal,Sathishkumar Chandrakumar,Irene Santiago Tierno et al.
Mahesh Agarwal et al.
Activated neutrophils kill retinal endothelial cells (ECs) in early diabetic retinopathy, but how neutrophils become activated in diabetes is not well understood. We found that lysyl oxidase (LOX), whose matrix-localized form activates reti...
Dual-Input Regulation of β-Cell Proliferation by ATF6α and Glucose via E2F1 [0.03%]
ATF6α和葡萄糖通过E2F1双重调节胰岛β细胞增殖
Huguet V Landa-Galvan,Thalia A Castro,Jahi J Noel et al.
Huguet V Landa-Galvan et al.
Endoplasmic reticulum stress response mediator activating transcription factor 6 (ATF6α) increases pancreatic β-cell proliferation in a glucose-dependent manner, but the mechanism remains unknown. ATF6α activation upregulated mRNA and pr...
Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation [0.03%]
β细胞丢失和低度炎症小鼠模型胰岛微血管稳态的破坏
Luciana Mateus Gonçalves,Isha Shirvaikar,Konstandina Sideris et al.
Luciana Mateus Gonçalves et al.
Pericyte dysfunction is an early event in type 1 diabetes in humans, but how it affects islet microvascular homeostasis in vivo is unknown. We sought to determine whether vascular integrity and blood flow regulation in islets were impaired ...
Erratum. Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways. Diabetes 2025;74:427-438 [0.03%]
NOTCH3功能获得性变异通过激活衰老通路导致家族性部分脂代谢不良。《糖尿病》杂志2025年;74:427-438
Abhimanyu Garg,Chao Xing,Anil K Agarwal et al.
Abhimanyu Garg et al.
In the above-cited article, the variant p.Asp1603Tyr was mistakenly given as p.Ala1603Tyr in the abstract, on p. 429 (second column, fourth row), and in the legend to Fig. 1. In addition, typographical errors in Table 1 were present for the...
Published Erratum
Diabetes. 2025 Oct 28:db26er01a. DOI:10.2337/db26-er01a 2025
Gut Microbiota-Decanoic Acid-Interleukin-17A Axis Orchestrates Hyperglycemia-Induced Osteoporosis in Male Mice [0.03%]
肠道微生物群-癸酸-白细胞介素-17A轴调控雄性小鼠高血糖诱导的骨质疏松症
Tao Jiang,Changkun Li,Zhengcan Pan et al.
Tao Jiang et al.
Hyperglycemia (HG) is a well-established risk factor for secondary osteoporosis, primarily due to suppressed osteoblast activity. While gut microbiota (GM) dysbiosis has been implicated in various diseases, its role in HG-induced osteoporos...
Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring [0.03%]
母体肥胖使妊娠期雌性后代葡萄糖耐量受损
Liping Qiao,Cindy Lu,Sarah Saget et al.
Liping Qiao et al.
Maternal obesity is a known risk factor for metabolic dysfunction in offspring; however, its effect on metabolism during pregnancy in female offspring remains unclear. This study investigated how maternal obesity, induced by high-fat (HF) f...
Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice [0.03%]
通过策略性降低杂合胰岛素肽的形成显著推迟NOD小鼠糖尿病的发生
Jason Groegler,Kaitlin Mangold,Kelli Nicholson et al.
Jason Groegler et al.
Hybrid insulin peptides (HIPs) have been identified as targets of autoreactive T cells in type 1 diabetes, although their causal role in disease pathogenesis has remained unclear. We demonstrated that a single leucine-to-isoleucine substitu...
From Sideshow to Center Stage: Targeting the Ghrelin System Belongs in the Big Tent of Obesity Therapeutics [0.03%]
从冷门到热门：食欲素系统的减肥潜力不容小觑
Jeffrey M Zigman
Jeffrey M Zigman
Miguel López,Rubén Nogueiras
Miguel López