ABCC8 Missense Variants and Disease: Loss or Gain? This Is the Question [0.03%]
ABCC8错义变异与疾病：丢失还是获得？这就是问题所在
Fabrizio Barbetti,Paul Thornton
Fabrizio Barbetti
Editorial
Diabetes. 2026 Jan 1;75(1):19-21. DOI:10.2337/dbi25-0029 2026
Dickkopf 3 in Urine: A Help for Prioritizing Management of Kidney Disease in Type 2 Diabetes [0.03%]
尿液中的Dickkopf 3在2型糖尿病肾病管理决策中的作用
Peter Rossing
Peter Rossing
Editorial
Diabetes. 2026 Jan 1;75(1):17-18. DOI:10.2337/dbi25-0045 2026
Imaging Hypoxia in the Diabetic Retina: A Potential Early-Detection Imaging Biomarker Before Detectable Retinopathy in Diabetes [0.03%]
糖尿病视网膜病变影像生物标志物的检测：在可检测糖尿病视网膜病变之前发现缺氧现象
Md Imam Uddin,Blake Dieckmann,David E Burgos
Md Imam Uddin
Hyperglycemia causes retinal hypoxia. Hypoxia may lead to apoptosis of retinal cells. Retinal hypoxia can be detected before any detectable changes in the diabetic retina. HYPOX-4 is a powerful early diagnostic imaging method to detect hypo...
Toward Scientific Rigor: Setting Standards for Indirect Calorimetry Analysis and Reporting [0.03%]
迈向科学严谨性——设定间接热量测量分析和报告的标准
Elizabeth L Lieu,Mark A Herman,Sean M Hartig
Elizabeth L Lieu
Indirect calorimetry determines energy expenditure by measuring respiratory gas exchange. The approach is based on the principle that nutrient metabolism consumes O2 and produces CO2 and water in predictable ratios that can be compared with...
Mitochondrial mGPDH Modulates Fibroblast Function in Diabetic Wound Healing via the SIRT1-c-Myc-TGF-β1 Axis [0.03%]
线粒体mGPDH通过SIRT1-c-Myc-TGF-β1轴调节糖尿病伤口愈合中成纤维细胞的功能
Ling Zhou,Yue Hong,Xing Li et al.
Ling Zhou et al.
Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is elevated in diabetic wounds; its inhibition enhances extracellular matrix production and wound closure. mGPDH deficiency activates SIRT1, deacetylating c-Myc to boost TGF-β1 and e...
miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in Mice [0.03%]
小鼠 miR-494 缺失可改善肥胖独立的糖代谢
Lucia Sugawara,Katsutaro Morino,Hirotaka Iwasaki et al.
Lucia Sugawara et al.
The browning of white adipose tissue (WAT) enhances thermogenesis and represents a promising approach for combating obesity and metabolic disorders. miRNA-494 (miR-494) acts as a suppressor of browning in cultured adipocytes via regulation ...
Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression [0.03%]
2型糖尿病遗传风险和1型糖尿病异质性和进展性
Taylor M Triolo,Jay M Sosenko,David Cuthbertson et al.
Taylor M Triolo et al.
Insulin secretion varies widely in preclinical type 1 diabetes. To understand the pathogenesis of this metabolic heterogeneity, we asked whether genetic predisposition to type 2 diabetes, quantified by a type 2 diabetes genetic risk score (...
Phosphatidylserine Supplementation Improves Metabolic Liver Disease and Glycemic Control in the Presence of Suppressed Oxidative Glucose Metabolism [0.03%]
磷脂酰丝氨酸补充改善代谢性肝病和糖代谢控制并抑制氧化葡萄糖代谢
Li Dong,Sihan Lin,John Slavin et al.
Li Dong et al.
Type 2 diabetes and obesity are commonly accompanied by metabolic dysfunction-associated steatotic liver disease (MASLD), increasing the risk of developing metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. The early stag...
Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue [0.03%]
TUG分子调节改变是胰岛素抵抗的人体脂肪组织的核心特征
Jordan W Strober,Kasper W Ter Horst,Daeun Sung et al.
Jordan W Strober et al.
White adipose tissue (WAT) insulin resistance (IR) is a central feature of metabolic syndrome; however, data regarding defects in WAT insulin signaling in humans with IR is limited. To determine which defects in WAT insulin signaling are as...