Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretion [0.03%]
α细胞线粒体磷酸烯醇式丙酮酸循环的氨基酸感受机制不影响胰高血糖素分泌而调节胞内钙离子水平
Erli Jin,Hannah R Foster,Evgeniy Potapenko et al.
Erli Jin et al.
Our studies identify a role for the α-cell phosphoenolpyruvate cycle in sensing amino acids under hypoglycemic conditions. Leucine, in the presence of glutamine, opposes alanine/arginine-stimulated Ca2+ influx and glucagon secretion. Pyruv...
GLP-1, Pancreatic β-Cells, and Insulin Secretion: What We Know and Where We Need to Go [0.03%]
GLP-1、胰岛β细胞和胰岛素分泌：我们所知与需要探索的方向
Éverton L Vogt,Alicia J Kowaltowski
Éverton L Vogt
GLP-1 and its analogs enhance insulin secretion, but the specific intracellular mechanisms in β-cells remain unclear. Key intracellular mediators including calcium, glutamate, γ-aminobutyric acid, serotonin, and urocortin-3 are modulated ...
Identifying Insulin Autoantibodies With Differential Risk in Type 1 Diabetes With a Novel Bridging ELISA [0.03%]
一种新型搭桥酶联免疫吸附试验在1型糖尿病中鉴定具有不同风险的胰岛素自身抗体
Xiaofan Jia,Caiguo Zhang,Kathleen Waugh et al.
Xiaofan Jia et al.
In global type 1 diabetes (T1D) population screening studies, there is an urgent need for a highly sensitive and specific insulin autoantibody (IAA) assay that can be implemented across multiple laboratories. This study aimed to develop and...
Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets [0.03%]
胰岛α细胞旁分泌激素信号通过调节β细胞的微管动力学促进小鼠和人类胰岛中的胰岛素分泌
Kung-Hsien Ho,Syed N Barmaver,Shannon E Gibson et al.
Kung-Hsien Ho et al.
The microtubule network in β-cells attenuates insulin secretion by pulling insulin secretory granules away from the plasma membrane. Thus, high-glucose-induced microtubule remodeling is required for robust glucose-stimulated insulin secret...
Long Duration of Type 2 Diabetes Drives Erythrocyte-Induced Vascular Endothelial Dysfunction: A Link to miRNA-210-3p [0.03%]
糖尿病病程驱动红细胞诱导血管内皮功能障碍：miRNA-210-3p的作用机制
Eftychia Kontidou,Aida Collado,Rawan Humoud et al.
Eftychia Kontidou et al.
Type 2 diabetes increases cardiovascular risk, with endothelial dysfunction playing a key role. Prolonged disease duration exacerbates cardiovascular risk, but the underlying mechanisms remain unclear. We previously demonstrated that red bl...
Angiotensin II-Induced Ferroptosis in Epithelial Cells Contributes to Kidney Injury via SP1-DPEP1-Mediated SLC3A2 Degradation [0.03%]
血管紧张素II诱导的上皮细胞铁死亡介导肾损伤的新机制：SP1-DPEP1-SLC3A2轴调节铁死亡导致急性肾损伤
Yuan Tian,Ge Yang,Qihe Zhang et al.
Yuan Tian et al.
Angiotensin II (AngII) activation, a key driver of diabetes pathogenesis and associated complications, induces kidney injury by promoting oxidative stress and inflammation. Ferroptosis is an iron-dependent regulated cell death, playing a cr...
Adipocyte Leptin Signaling Regulates Glycemia and Cardiovascular Function by Enhancing Brown Adipose Tissue Thermogenesis in Obese Male Mice [0.03%]
肥胖男鼠的脂肪细胞瘦素信号通过增强棕色脂肪组织产热调节血糖和心血管功能
Yoichi Ono,Simone Kennard,Benjamin T Wall et al.
Yoichi Ono et al.
Although control of metabolism by leptin is primarily viewed as centrally mediated, leptin has also been shown to directly regulate adipocyte function. However, the impact of the peripheral effects of leptin on systemic metabolism, especial...
Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function [0.03%]
活化的胰内神经元胆碱能支链中的毒蕈碱受体信号传导是外分泌胰腺功能的副交感神经胆碱能控制所必需的
Noah J Levi,Alejandro Tamayo Garcia,Madina Sokolov et al.
Noah J Levi et al.
The parasympathetic nervous system modulates hormone and digestive enzyme secretion from the pancreas. However, the mechanisms of neuroeffector transmission within the final parasympathetic pathway in the pancreas have not been elucidated. ...
Cluster Analysis of Younger-Onset Type 2 Diabetes in an Asian Cohort Reveals Distinct Subgroups With Differential Pathophysiology and Outcomes [0.03%]
亚洲年轻发病2型糖尿病患者的聚类分析发现了具有不同病理生理和临床结局的亚群
Clara Si Hua Tan,Kai Xiang Kee,Huili Zheng et al.
Clara Si Hua Tan et al.
To understand the heterogeneity of younger-onset type 2 diabetes, clinical data-driven clustering was performed, which identified three distinct subgroups that were replicated in an independent cohort. Compared with the mild obesity-related...
Integrating Polygenic Scores and Family History for Type 2 Diabetes Prediction in an East Asian Population: Insights From the Taiwan Biobank [0.03%]
整合多基因评分和家族史用于东亚人群2型糖尿病预测：来自台湾生物银行的启示
Wen-Ling Liao,Chun-Wen Cheng,Ya-Wen Chang et al.
Wen-Ling Liao et al.
Type 2 diabetes is influenced by genetic and environmental factors. Although polygenic risk scores (PRS) and family history (FH) are established predictors, their combined utility in East Asian populations is unclear. We evaluated the predi...