Molecular Mechanisms of FLASH Radiotherapy in Alleviating Lung Normal Tissue Injury: Insights from Single-Cell Sequencing [0.03%]
FLASH放射治疗减轻肺正常组织损伤的分子机制：单细胞测序的新见解
Ziyang Guo,Yin Luo,Jianxin Wang
Ziyang Guo
FLASH radiotherapy (FLASH-RT), with its ultra-high dose rate (≥40 Gy/s) that causes the "FLASH effect," significantly reduces normal tissue toxicity while maintaining tumor cytotoxicity, but its molecular mechanisms have not been fully elu...
Silencing GPx1 Synergizes with Ionizing Radiation to Enhance the Elimination of Leukemia Stem Cells [0.03%]
GPx1沉默与电离辐射协同增强白血病干细胞的清除作用
Yaoqi Gui,Jingsong Cheng,Yi Mo et al.
Yaoqi Gui et al.
Leukemia stem cells (LSCs) are a key factor leading to the recurrence and drug resistance in acute myeloid leukemia (AML). Notably, the persistence of radiotherapy-resistant LSCs has been identified as a critical determinant of post-hematop...
Early DNA Damage Study at the Molecular Scale in a Proton-Irradiated Scenario: A Full Assessment of Tetranucleosome DNA Strand Breakage [0.03%]
早期质子辐射四核小体DNA分子损伤研究：完整评估DNA链断点分布特征
Zongqing Tang,Qingxuan Xie,Xudong Liu et al.
Zongqing Tang et al.
DNA is highly susceptible to damage from high-energy particles, making molecular-level computation of DNA damage essential for understanding the underlying molecular mechanisms. In this study, we conducted an in-depth investigation of DNA s...
Effects of 15 cGy GCRsim Space Radiation on Conditioned Fear and Stress Responses in Stress Resilient and Vulnerable Rats: Implications for Astronaut Sleep, Health and Mission Performance [0.03%]
模拟太空辐射对压力易感大鼠和抗压大鼠条件恐惧和应激反应的影响：对航天员睡眠、健康及任务表现的启示
Austin M Adkins,Alea F Boden,Namrata Singh et al.
Austin M Adkins et al.
The long durations of the proposed NASA Mars missions will expose astronauts to space radiation (SR), which has detrimental effects on brain function that could impair their ability to appropriately cope with any additional unexpected stres...
Radiation Adaptive Response Enhances Hematopoietic Stem and Progenitor Cells Radioresistance in Mice: IL-17 Signaling Pathway Activation as the Underlying Mechanism [0.03%]
辐照诱导的辐射适应反应增强小鼠造血干细胞及祖细胞放射耐受：激活的IL-17信号通路是潜在机制
Ying Fan,Yunqi Mo,Zhanyu Wang et al.
Ying Fan et al.
Radiation adaptive response (RAR) significantly improves resistance to subsequent high-dose radiation exposure. While hematopoietic stem and progenitor cells (HSPCs) are known to be crucial for radiation protection, their specific roles and...
Edouard Azzam,Takamitsu Kato,Susan Bailey et al.
Edouard Azzam et al.
Influence of Cell Size Changes after Irradiation on Reliability of an Impedance Measurement-based Hematology Analyzer [0.03%]
辐照后细胞尺寸变化对阻抗测量血液分析仪可靠性的影响研究
Timo Orben,Taro Matsui,Kazushi Suzuki et al.
Timo Orben et al.
Radiological nuclear scenarios remain a persistent threat due to civil use and military possession of radiation sources. Therefore, it is crucial to be prepared for events involving a large number of patients exposed to radiation. In such c...
Influence of LET on Low-dose Radiation Responses: Signatures of Hyper-radiosensitivity after High-LET Irradiation [0.03%]
不同线能量传递辐射的低剂量响应差异：高 LET 辐射后的超放射敏感性特征
K Sennhenn,S Polgár,A Loewer et al.
K Sennhenn et al.
Hyper-radiosensitivity refers to increased cellular sensitivity at low doses of ionizing radiation and is not accurately captured by classical radiobiological models. Although predominantly studied in the context of low-LET radiation, such ...
Mortality among U.S. Industrial Radiographers Exposed to Ionizing Radiation, 1969-2019 [0.03%]
1969-2019年美国工业射线检测人员职业辐射暴露死亡率研究
John D Boice Jr,Sarah S Cohen,Michael T Mumma et al.
John D Boice Jr et al.
A cohort mortality study was conducted of 123,401 industrial radiographers in the United States to estimate risks following protracted radiation exposures. The cohort was constructed from the Nuclear Regulatory Commission Radiation Exposure...
Unilateral Fractionated Thoracic Irradiation Induces Abscopal Injury in Contralateral Lung through NF-κB Pathway [0.03%]
单侧肺分次照射通过NF-kB通路诱发对侧肺的远隔效应
Xinglong Liu,Yimeng Song,Songling Hu et al.
Xinglong Liu et al.
Radiotherapy may cause acute and late damage to off-target abscopal tissues, and the underlying signaling factors need further exploration. This study aimed to investigate whether local irradiation could induce damage in non-irradiated absc...