The Therapeutic Potential of Human Umbilical Cord Mesenchymal Stem Cell-derived Exosomes in Acute Radiation Intestinal Injury [0.03%]
人脐带间充质干细胞外泌体治疗急性辐射性肠损伤的潜力研究
Jianping Yu,Gaosheng Yang,Yanping Yang et al.
Jianping Yu et al.
Radiation-induced bowel injury is a common complication of radiation therapy for pelvic or abdominal cancers, with its occurrence increasing worldwide. Current treatments face significant challenges, and the limitations of conventional meth...
Lattice Radiation Therapy Delays Progression and Extends Survival for Dogs with Macroscopic Soft Tissue Sarcoma [0.03%]
立体定向放射治疗可延缓犬宏观软组织肉瘤进展并延长生存期
V R Morales,J N Bryan,S Chu et al.
V R Morales et al.
Soft tissue sarcomas are common tumors in dogs with many pathologic and molecular cross-species similarities existing between dogs and humans. Spatially fractionated radiotherapy, utilizing an intensity-modulated technique known as Lattice ...
Impact of Dose Administration Schedule and Orthovoltage X-ray Beam Quality on Survival and Dose Response Relationships in C57BL/6J Mouse Models of Acute Radiation Syndrome [0.03%]
剂量给药方案和正伏特X射线束质量对C57BL/6J小鼠急性放射综合征模型存活率及剂量反应关系的影响
Tyler Beach,Tyson J McDonald,Autumn Rassmusen et al.
Tyler Beach et al.
Total-body irradiation (TBI) and partial-body irradiation (PBI) mouse models have been used for many years to develop safe and effective medical countermeasures (MCMs) against the acute radiation syndrome (ARS). ARS MCM development will ben...
Apigenin Enhances the Radiosensitivity of TNBC Cells by Improving cGAS-STING Pathway Activity [0.03%]
阿皮根素通过提高cGAS-STING通路活性增强三阴性乳腺癌细胞的放射敏感性
Xiongxiong Liu,Youming Zhu,Tong Zheng et al.
Xiongxiong Liu et al.
Apigenin inhibits proliferation and induces apoptosis in triple-negative breast cancer (TNBC) cells, processes linked to DNA damage. However, the combined effect of apigenin and radiation on TNBC cells remains unclear. This study aimed to d...
Low-Dose Ionizing Radiation Modulates Translation Efficiency in Human Lung Fibroblasts [0.03%]
低剂量电离辐射通过调节人肺成纤维细胞的翻译效率发挥生物学作用
Rosette N Tamaddon,Martin Roffe,Antonella Bertucci et al.
Rosette N Tamaddon et al.
Understanding the cellular responses to low-dose ionizing radiation exposure (≤ 0.1 Gy) is essential for developing evidence-based radiation protection policies. Unlike high-dose radiation exposure, which is known to alter gene expression ...
Bias in Low Dose Risk Estimation due to the Constant RBE Assumption in RERF Studies [0.03%]
由于RERF研究中恒定相对生物效应假设导致低剂量风险估计偏差
Richard Sposto
Richard Sposto
Radiation exposure from the atomic bombs in Hiroshima and Nagasaki consisted of both gamma and neutron radiation. Because the main goal of analyzing Radiation Effects Research Foundation (RERF) data is to estimate the increased risk from ga...
De novo Copy Number Variations in the Offspring of Male Mice Chronically Exposed to Various Low Dose-Rates of Ionizing Radiation [0.03%]
长期低剂量率电离辐射暴露父本小鼠后代新生的拷贝数变异
Keiji Ogura,Yoshiko Ayabe,Chihiro Harada et al.
Keiji Ogura et al.
Previously, we conducted a large-scale pathology study on the transgenerational effects of ionizing radiation, examining the lifespan and causes of death in the first- (F1) and second- (F2) generation offspring of male C57BL/6J mice (F0) ex...
The FLASH Effect in 3D and 2D Models: Preserving Tumor Control while Reducing Apoptosis in Normal Cells [0.03%]
FLASH效应的三维和二维模型研究：肿瘤控制作用不变而正常细胞凋亡减少
Andrea Scarmelotto,Emma Lambert,Victor Delprat et al.
Andrea Scarmelotto et al.
Irradiation at ultra-high dose rates is gaining increased attention due to its ability to limit damage to surrounding healthy tissues, thereby preventing radiation-induced side effects. Although there are some exceptions, this protective ef...
Differential Radiosensitivity in T-Cell Subsets: Metabolic and Antioxidative Mechanisms Underlying Naïve T-Cell Vulnerability [0.03%]
T细胞亚群的差异放射敏感性：初代T细胞脆弱性的代谢及抗氧化机制研究
Lorreta Yun-Tien Lin,Anika Kot,Albert J Fornace Jr et al.
Lorreta Yun-Tien Lin et al.
T cells, which are generally highly sensitive to DNA damage-induced cell death, exhibit distinct responses to ionizing radiation (IR) depending on their differentiation state. In this study, we investigated the heightened radiosensitivity o...
Enhanced Response to Radiopharmaceutical Therapy in Preclinical Tumor Models with XRD-0394, a Dual Inhibitor of ATM Kinase and DNA-PKcs [0.03%]
一种ATM激酶和DNA-PKcs的双抑制剂XRD-0394可增强放射性药物治疗的疗效：基于肿瘤模型的药理学研究
Caroline P Kerr,Won Jong Jin,Alejandro J Oñate et al.
Caroline P Kerr et al.
Enhanced DNA repair is a common mechanism of radiation resistance. XRD-0394, a novel small molecule dual inhibitor of ataxia telangiectasia mutated (ATM) kinase and deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PKcs), may sensit...