Enhanced Response to Radiopharmaceutical Therapy in Preclinical Tumor Models with XRD-0394, a Dual Inhibitor of ATM Kinase and DNA-PKcs
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Enhanced DNA repair is a common mechanism of radiation resistance. XRD-0394, a novel small molecule dual inhibitor of ataxia telangiectasia mutated (ATM) kinase and deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PKcs), may sensitize tumor cells to k... ...
