Radiation Induces Persistent Dysregulation and Functional Impairment in CD8+ T Cell Immunity [0.03%]
辐射诱导CD8+t细胞免疫的持续性调控和功能障碍
Anika Kot,Lorreta Yun-Tien Lin,Zhinuo Jiang et al.
Anika Kot et al.
In addition to immediate cell lethality, radiation exposure has long-term effects on the immune system, particularly T lymphocytes, causing persistent functional abnormalities post-exposure. Uncertainties remain regarding the long-lasting c...
Neutrophil-to-Lymphocyte Ratio in Laryngeal SQCC Treated by Radiotherapy: Prognostic and Predictive Value [0.03%]
放射治疗喉部鳞状细胞癌的中性粒细胞与淋巴细胞比率的预后和预测价值评估
Noam Koch,Eyal Yosefof,Ofir Zavdy et al.
Noam Koch et al.
Laryngeal squamous cell carcinoma (SQCC), in both early and advanced stages, is often treated non-surgically with definitive-intent radiotherapy or chemoradiotherapy. In advanced-stage disease, uninvolved lymphatic structures of the neck ar...
Combination Therapy with Pharmacological Ascorbate and Rucosopasem Selectively Radiosensitizes Colorectal Tumors to Clinically Relevant Radiation Doses [0.03%]
药用维生素C和Rucosispasem联合治疗选择性地增强了结直肠肿瘤对临床相关放射剂量的敏感性
Benjamin N George,Casey F Pulliam,Michael S Petronek et al.
Benjamin N George et al.
Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase mimetics can selectively modulate the effects of radiotherapy in tumors and normal tissues by enhancing oxidative stress in tumors and mitigating it in normal tissues. Howe...
Longitudinal Serum Proteomic Profiling of Nonhuman Primates Exposed to Total-body Gamma Radiation and Treated with BBT-059 [0.03%]
全身γ射线照射后用BBT-059治疗的非人灵长类动物纵向血清蛋白质谱分析
Alana D Carpenter,Matthew W Brink,Yaoxiang Li et al.
Alana D Carpenter et al.
Several radiation medical countermeasures (MCMs) are currently approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). Continued development of additional can...
Chronic Inflammation in Irradiated Mouse Mammary Glands: A Transcriptome Sequencing Analysis [0.03%]
辐射小鼠乳腺的慢性炎症：转录组测序分析
Xiaoran Shi,Junyang Chen,Zhongshuang Liu et al.
Xiaoran Shi et al.
Normal tissues exposed to radiation during radiotherapy or radiation accidents are susceptible to chronic inflammation, which poses a significant health concern. Here, we used the mouse mammary gland as a model to investigate radiation-indu...
Changes in Yields of Water Radiolysis Species and Strand Breaks of Pbr322 Plasmid DNA under Ultra-high Dose Rate C Ions: Towards the Elucidation of the Mechanism of FLASH Radiotherapy [0.03%]
超高速度率碳离子辐照下水辐射解产物产额及pbr322质粒dna链断裂数变化：向阐明闪充放疗机制迈进
Taisei Mamiya,Koki Kasamatsu,Taku Inaniwa et al.
Taisei Mamiya et al.
To clarify the mechanisms of FLASH radiotherapy using C ion beams (373 MeV/u and 90 MeV/u), we investigated the dose rate dependence of yields of water radiolysis species (OH radicals, hydrated electrons, and hydrogen peroxide). Additionall...
Effects of Partial-body, Continuous/Pulse Irradiation at Dose Rates from Flash to Conventional Rates on the Level of Surviving Blood Lymphocytes: Modeling Approach. III. Lymphocyte Survival Is a Biomarker of Flash Sparing Effects [0.03%]
剂量率从闪光到常规速率的全身连续/脉冲照射对存活外周血淋巴细胞水平影响的模型研究第三部分：淋巴细胞存活是闪光减免效应的生物标志物
Francis A Cucinotta,Olga A Smirnova
Francis A Cucinotta
Experimental data on magnitudes of sparing effects of whole-abdominal pulse irradiation, whole-brain pulse irradiation, and bilateral thorax pulse/continuous irradiation at high doses and dose rates from conventional to FLASH irradiation ra...
The FLASH Effect in 3D and 2D Models: Preserving Tumor Control while Reducing Apoptosis in Normal Cells [0.03%]
FLASH效应的三维和二维模型研究：在控制肿瘤的同时减少正常细胞凋亡
Andrea Scarmelotto,Emma Lambert,Victor Delprat et al.
Andrea Scarmelotto et al.
Irradiation at ultra-high dose rates is gaining increased attention due to its ability to limit damage to surrounding healthy tissues, thereby preventing radiation-induced side effects. Although there are some exceptions, this protective ef...
KRT6A Impairs Radiosensitivity in Cervical Squamous Cell Carcinoma by Enhancing Fatty Acid Synthesis [0.03%]
通过增强脂肪酸合成抑制宫颈鳞癌放射敏感性的KRT6A基因变异型的研究
Manping Zha,Yanli Du
Manping Zha
Cervical squamous cell carcinoma (CESC), a subtype of cervical cancer, is an aggressive cancer. Radiotherapy is a key treatment for locally advanced cases, but its success is often limited by radioresistance. Therefore, this study explores ...
Chromosomal Instability: A Potential Biomarker of Radiation Response [0.03%]
辐射反应潜在生物标志物——染色体不稳定性的研究进展
Nikki N Messick,Yeseo Choi,Patricia Tan et al.
Nikki N Messick et al.
Radiotherapy is a widely used cancer treatment modality with more than 70% of head and neck cancer (HNC) patients receiving it in either the definitive or adjuvant settings. Currently, all HNC patients, regardless of human papillomavirus (H...