Adenosine drives suppression of CD16low NK cell responses against HGSC via NKG2A:HLA-E interactions [0.03%]
腺苷通过NKG2A:HLA-E相互作用驱动对HGSC的CD16lowNK细胞反应的抑制作用
Anna P Nicolela,Sarah Nersesian,Stacey N Lee et al.
Anna P Nicolela et al.
High grade serous carcinoma (HGSC) of the ovary remains the deadliest gynecologic cancer, with five-year survival rates of less than 50%. Remission is usually achieved by surgical debulking and chemotherapy, but most (∼70%) of patients ult...
The CNC-bZIP transcription factor Nrf2 controls expression of matrix metalloproteases in murine macrophages [0.03%]
CNC-bZIP转录因子Nrf2调控小鼠巨噬细胞中基质金属蛋白酶的表达
Abel D Ang,Sharadha Dayalan Naidu,Oliver J Read et al.
Abel D Ang et al.
Liver fibrosis is a chronic condition that often leads to organ failure. Currently, no effective treatment exists for advanced liver fibrosis. De-repression of the transcription factor Nrf2, by inhibition of the ubiquitin ligase substrate a...
HER2-Specific Synthetic Antigen Receptor (SAR) T Cell Therapy Synergizes with Radiotherapy to Provide Improved Anti-Tumor Efficacy in Non-Small Cell Lung Cancer (NSCLC) [0.03%]
HER2特异性合成抗原受体（SAR）T细胞疗法与放疗协同作用可提高非小细胞肺癌的疗效
Olga-Demetra Biziotis,Christopher M Silvestri,Allyson E Moore et al.
Olga-Demetra Biziotis et al.
In NSCLC, radiotherapy mediates cytotoxicity but also activates radioresistance drivers like HER2. We investigated radiotherapy combined with HER2-targeted T cell therapy in a NSCLC model. The anti-tumor efficacy of radiotherapy and enginee...
Cytokines and growth factors produced and released by human eosinophils: lessons from cocultures and omics studies [0.03%]
人嗜酸性粒细胞产生和释放的细胞因子和生长因子：共培养和组学研究的经验教训
Stephane Esnault,Arnaud Dendooven,Emeline Delaunay et al.
Stephane Esnault et al.
Besides their largely specific and abundant toxic granule proteins, their Charcot-Leyden crystals, DNA traps, and the release of leukotrienes, human eosinophils are often seen as affecting the immune response and tissue remodeling due to th...
Immune exhaustion, the culprit for long COVID and chronic complications [0.03%]
免疫系统衰竭是长新冠和慢性后遗症的罪魁祸首
Shuo Geng,Liwu Li
Shuo Geng
Loss of NF-κB inducing Kinase (NIK) affects eosinophilopoiesis in a murine model of Hypereosinophilic Syndrome [0.03%]
NF-κB诱导 kinase(NIK)的丢失影响了子鼠霍廷菲林综合征的嗜酸性粒细胞生成
Brie Trusiano,Rebekah A Smith,Cassandra S Poole et al.
Brie Trusiano et al.
NF-κB inducing kinase (NIK), an upstream regulator of the noncanonical NF-κB signaling pathway, is implicated in the development of Hypereosinophilic-like syndrome (HES) in mice. HES in human patients is defined by 1.5x109 cells/L circula...
Class A Scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer [0.03%]
模式识别受体促进小鼠自发性乳腺肿瘤的进程并诱导独特的巨噬细胞表型
Behjatolah Monzavi-Karbassi,Thomas Kelly,Fariba Jousheghany et al.
Behjatolah Monzavi-Karbassi et al.
Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenge...
Transforming Growth Factor Beta/Smad3/GATA3 Axis Mediates the Therapeutic Effect of Ephedra sinica Stapf Polysaccharide in Allergic Rhinitis [0.03%]
麻黄 polysaccharide通过调节TGF-β/Smad3/GATA3信号轴缓解过敏性鼻炎的作用及机制研究
Jingfei Zhang,Zhixuan Wu,Ru Zhang
Jingfei Zhang
Allergic rhinitis (AR) is a prevalent inflammatory disorder with limited therapeutic options. Ephedra sinica Stapf (ESP), a traditional Chinese herb, has shown potential in respiratory diseases, but its bioactive components and mechanisms r...
Novel role of Hippo effector YAP1 as a rheostat controlling inflammation in dendritic cells [0.03%]
Hippo效应物YAP1在控制树突状细胞炎症中的新作用
Sara Monaci,Federica Coppola,Irene Filippi et al.
Sara Monaci et al.
Dendritic cells (DCs) function within tissues that experience wide fluctuations in oxygen availability, and these hypoxic environments exert a strong influence on innate immune activity. In this context, we identify the Hippo pathway effect...
RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization [0.03%]
RABEP1通过溶酶体回收和肌动蛋白聚合调节中性粒细胞迁移
Daniel H Kim,Ramizah Syahirah,Conwy Zheng et al.
Daniel H Kim et al.
Neutrophils are the first responders of our innate immune system, crucial for defense against various infections. The intricate regulation of neutrophil migration is essential for neutrophil function. However, a complete mechanistic underst...