WGCNA and machine learning identify mitochondria programmed cell death-related genes as diagnostic biomarkers for septic shock [0.03%]
利用WGCNA和机器学习鉴定与脓毒症休克诊断相关的线粒体程序性细胞死亡相关基因标志物
Di Yu,Zhongbin Lai,Jingzhao Xia et al.
Di Yu et al.
Septic shock (SS), the most severe stage of sepsis, has a high mortality rate. Mitochondria-mediated programmed cell death (MPCD) plays a key role in SS pathogenesis, but its diagnostic value remains unclear. This study integrated the GEO p...
Neutrophil Biology and Fate Reprogramming in Bacterial Infections: Mechanisms, Plasticity, and Therapeutic Targeting [0.03%]
细菌感染中的中性粒细胞生物学和命运重编程：机制、可塑性和治疗靶向
Asmaa H Mahmoud,Maria A Colombatti Olivieri,John P Bannantine et al.
Asmaa H Mahmoud et al.
Neutrophils are essential leukocytes in bacterial infections, with their fate and immune regulation critically shaping disease outcomes. They eliminate pathogens through phagocytosis, degranulation, oxidative burst-mediated killing, and the...
Uncovering the Gut-Immune-Joint Axis: Causal Links Between Gut Microbiota, Immune Cells, and Osteoarthritis [0.03%]
揭秘肠-免疫-关节轴：肠道菌群、免疫细胞与骨关节炎的因果关系
Yuxi Liu,Zhilei Zhang,Bing Zhao et al.
Yuxi Liu et al.
Gut microbiota have been increasingly implicated in osteoarthritis (OA), but causal pathways remain unclear. Using the Gut-Immune-Joint Axis framework, we analyzed publicly available genome-wide association study (GWAS) summary statistics f...
Human macrophage phagocytosis of lung cancer cells induced by CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded lipid nanoparticles [0.03%]
携带siRNA的脂质纳米颗粒介导的吞噬检查点敲低可增强人类巨噬细胞对CD47阻断诱导的人肺癌细胞的吞噬作用
Kristian W Antonsen,Henriette Mathiesen,Henriette N Friis et al.
Kristian W Antonsen et al.
Macrophages can phagocytose tumor cells. However, tumor cells may avoid phagocytosis by activating macrophage-expressed phagocytosis checkpoints such as SIRPα, LILRB1, or Siglec-10. Here, we investigated whether LNPs loaded with siRNA (siR...
Eosinophil Adaptation in the Intestine: Microenvironmental Cues and Regulatory Roles [0.03%]
肠嗜酸性粒细胞适应：微环境线索与调节作用
Yuande Wang,Heping Xu
Yuande Wang
Eosinophils are granulocytes that undergo extensive transcriptional and functional remodeling as they adapt to tissue-specific microenvironments, enabling them to perform context-dependent roles in both homeostasis and disease. The intestin...
Lymphocyte subsets: New hope for noninvasive biomarkers of prostate cancer [0.03%]
淋巴细胞亚群：前列腺癌无创生物标志物的新希望
Chunjin Ke,Wen Hu,Guoping Wang et al.
Chunjin Ke et al.
Tumorigenesis and progression are driven by immune dysregulation and escape, thus evaluating immune function is crucial for the identification of diseases or health conditions. Currently, there is a lack of non-invasive biomarkers in the ov...
The Role of Duffy Antigen Receptor for Chemokines in Acute Respiratory Distress Syndrome [0.03%]
趋化因子杜菲受体在急性呼吸窘迫综合征中的作用
Catherine N Moscinski,Christopher Born,Daithi S Heffernan
Catherine N Moscinski
Dysregulated inflammation in response to inciting events leads to severe end-organ dysfunction and failure, contributing to long-term morbidity and ultimately potentially death. Duffy Associated Receptor for Chemokines (DARC), a major regul...
A Biotin Ligation Assay Reveals a Complex Proxiome for HLA-A2 and Implicates MIA3 in Cell Surface Expression of MHC Class i Molecules [0.03%]
生物素连接测定显示HLA-A2的复杂近端组蛋白并揭示MIA3在I类主要组织相容性复合体分子细胞表面表达中的作用
William Mitchell,Émeric Leclerc,Denis Faubert et al.
William Mitchell et al.
Antigen presentation via MHC class I molecules (MHC-Is) is a turning point in the establishment of immune responses to endogenous threats, such as viruses. From their synthesis to their cell surface display, MHC-Is travel to many compartmen...
Single-cell RNA-seq of in vitro-cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency [0.03%]
单个培养的髓质胸腺上皮细胞的单细胞RNA测序揭示了Aire缺乏下的分化轨迹的保存
Romário Sousa Mascarenhas,Max Jordan Duarte,Pedro Paranhos Tanaka et al.
Romário Sousa Mascarenhas et al.
Central tolerance in the thymus is orchestrated by the autoimmune regulator (Aire), which enables medullary thymic epithelial cells (mTECs) to express tissue-restricted antigens (TRAs) and present them to developing T cells via MHC-II molec...
Mitochondrial Electron Transport Chain Modulation Orchestrates Divergent TLR3 and TLR7 Responses [0.03%]
线粒体电子传递链调控协调TLR3和TLR7的不同反应
Mary-Elizabeth Sheridan,Duale Ahmed,Malak Al Daraawi et al.
Mary-Elizabeth Sheridan et al.
Macrophages are on the front lines against viral infections and play a central role in initiating antiviral immune responses. They do this by sensing viral ligands through their arsenal of pattern recognition receptors, which fine-tune and ...