Single-cell RNA-seq of in vitro-cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency
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Central tolerance in the thymus is orchestrated by the autoimmune regulator (Aire), which enables medullary thymic epithelial cells (mTECs) to express tissue-restricted antigens (TRAs) and present them to developing T cells via MHC-II molecules. While Aire's ... ...
