H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability [0.03%]
IKZF3中H195Y突变通过抑制转录沉默活性和增加蛋白稳定性在小鼠前B淋巴细胞急性淋巴细胞白血病模型中的作用
Heidi Rysan,James A Iansavitchous,Trevor M Day et al.
Heidi Rysan et al.
IKZF3/Aiolos is a zinc-finger transcriptional transcription factor that functions as a transcriptional repressor in B cell development. IKZF3 mutations are associated with human diseases including immunodeficiency, leukemia and lymphoma. H1...
TNFR2-targeting biologics: Molecular mode of action, possible applications and future developments [0.03%]
靶向TNFR2的生物制剂：分子作用模式、潜在应用及未来发展方向
Olena Zaitseva,Harald Wajant
Olena Zaitseva
Tumor necrosis factor-α (TNF) and its receptors have emerged as key players in autoimmunity but also influence tumor development and the tumor microenvironment in many ways. TNF-inhibiting biologics are used very successfully in the clinic...
Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches [0.03%]
利用人工智能型流式细胞术方法表征台湾类风湿关节炎患者的免疫细胞亚群特征
Po-Yu Li,Yen-Po Tsao,Yi-Syuan Sun et al.
Po-Yu Li et al.
Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell pr...
Gut dysbiosis in early severe burns contributes to acute lung injury by impairing neutrophil chemotaxis [0.03%]
严重烧伤早期肠道菌群失调通过抑制中性粒细胞趋化作用参与急性肺损伤
Yuliang Sun,Ping Li,Xiaochuan Wang et al.
Yuliang Sun et al.
Severe burns complicated by acute lung injury are critical causes of respiratory failure and multiple organ dysfunction syndrome. Neutrophils extensively infiltrate lung tissues early postburn to mediate pulmonary damage, but the underlying...
Statin repurposing in gastrointestinal cancer: from metabolic reprogramming to immunoregulation [0.03%]
他汀类药物在胃肠肿瘤中的再利用：从代谢重组到免疫调节
Miaorong Xu,Chi-Chiu Yu,Henry Kwun-Hang Chung et al.
Miaorong Xu et al.
Cholesterol metabolism plays a pivotal role in gastrointestinal (GI) cancers, from fuelling tumor growth, facilitating metastatic niche formation, shaping tumor immunosuppressive microenvironment to promoting immunotherapy resistance. Parad...
The Predictive Value of Neutrophil Extracellular Trap-Related Risk Score in Prognosis and Tertiary Lymphoid Structure Features of Lung Adenocarcinoma Patients [0.03%]
中性粒细胞胞外陷阱相关风险评分预测肺腺癌患者预后及三级淋巴样结构特征的价值
Zhe Wang,Yingying Wang,Jiahui Zhou et al.
Zhe Wang et al.
Neutrophil extracellular traps (NETs) have been increasingly recognized as important modulators of tumor immunity. In this study, we investigated the prognostic significance of NETs-related genes expression and their impact on tertiary lymp...
Targeting CaMKIIδ Overcomes Therapy Resistance in Acute Myeloid Leukemia by Suppressing STAT3/CDK6/BCL-2 Survival Axis [0.03%]
靶向CaMKIIδ通过抑制STAT3/CDK6/BCL-2生存轴克服急性髓系白血病的治疗耐药性
Zhaoxing Wu,Shuwen Zheng,Mengyuan Li et al.
Zhaoxing Wu et al.
Relapse and therapy resistance remain major barriers to improving clinical outcomes in acute myeloid leukemia (AML), underscoring the need for actionable therapeutic targets. In this study, we identify calcium/calmodulin-dependent protein k...
IL-36 mediates immune activation in Sjögren's disease and may represent a novel biomarker of disease [0.03%]
白细胞介素36介导Sjögren综合征的免疫激活且可能是该病的一种新型生物标志物
Bayan Alhaddad,Theresa Wrynn,Jeremy Kiripolsky et al.
Bayan Alhaddad et al.
Sjögren's disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD...
Progenitor-Predominant Exhaustion in CIKs Reveals TIM-3 as a Superior Target for Enhancing CIK Cytotoxicity [0.03%]
TIM-3在CIK细胞中的调控作用及其作为提高CIK细胞毒性的治疗靶点的潜力
Jian Wang,Qin Wang,Jiahui Zhou et al.
Jian Wang et al.
Precursor exhausted and terminally exhausted T cells (Tpex and Tex) are associated with immune checkpoints, T-cell checkpoint blockade may improve patient survival. We assessed cytotoxic activity and PD-1/TIM-3 expressions of CD3+CD8+CD56+ ...
Single-Cell Transcriptomic Analysis Reveals RNA-Binding Protein Dysregulation in Immune Checkpoint Inhibitor-Induced Colitis [0.03%]
单细胞转录组分析揭示了免疫检查点抑制剂诱导结肠炎中RNA结合蛋白的失调
Haobei Ran,Lipan Zhang,Wentao Wang et al.
Haobei Ran et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing anti-tumor immunity, but their use is frequently complicated by immune-related adverse events (irAEs), particularly ICI-induced diarrhea and colitis. Growin...