Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures [0.03%]
自体荧光使人类白细胞培养中的EETosis的检测和量化成为可能
Masashi Akiyama,Koichi Kokame
Masashi Akiyama
Eosinophils are leukocytes involved in defense against multicellular parasites and other pathogens. Like neutrophils, eosinophils can undergo a cytolytic form of cell death known as eosinophil extracellular trap cell death (EETosis), during...
Cold Atmospheric Plasma as an Immunomodulator: Suppression of T-cell Hyperactivation and Graft-versus-Host Disease via Redox Regulation [0.03%]
冷等离子体通过调节细胞氧化还原稳态抑制T细胞过度活化及移植物抗宿主病的作用机制研究
Thoh Maikho,Raghavendra S Patwardhan,Binita Kislay Kumar et al.
Thoh Maikho et al.
Cold Atmospheric Plasma (CAP) has garnered significant attention in biomedical science, owing to its wide therapeutic applications in wound healing, disinfection, dentistry, cancer care and inflammation. Although, anti-inflammatory effects ...
Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis [0.03%]
纳武单抗和重组IL-7体外诱导脓毒症患者独特淋巴细胞免疫特征
Timothy Arthur Chandos Snow,Walter Pisciotta,Gladys Martir et al.
Timothy Arthur Chandos Snow et al.
Therapeutic modulation of sepsis-induced immune dysfunction by targeting lymphocyte dysfunction with recombinant IL-7 (rIL-7) and anti-PD-1 (e.g. nivolumab) has shown promise in preclinical and early clinical studies. Prior to conducting la...
Sarah Almas,Paige Lacy
Sarah Almas
Eosinophils are highly granulated white blood cells first identified as "granule blood cells" in the 19th century. In this review, we discuss techniques used to identify these unique cells and explore how they release a range of pro- and an...
Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer [0.03%]
免疫细胞景观揭示了五个与免疫相关的亚型和具有预后及治疗意义的分子特征（泛癌）
Hongjiu Wang,Na Wang,Siyu He et al.
Hongjiu Wang et al.
The immunotherapy represents the most promising new cancer treatment approach but due to the high heterogeneity of the tumor microenvironment among patients, only a small portion of patients respond to a certain immunotherapy. Therefore, id...
High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset [0.03%]
高维单细胞质谱流式分析IL-4诱导的人巨噬细胞揭示异质性和抗结肠炎亚群CD206high
Blanca E Callejas,Jared Schlechte,James A Sousa et al.
Blanca E Callejas et al.
Autologous cell therapy is a patient-embraced approach to inflammatory disease. Murine models demonstrate that alternatively activated (or regulatory) macrophages can reduce the severity of disease, and human macrophages (M0) educated with ...
SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity [0.03%]
无需酶活性的SHIP分子机制和脂质产物在巨噬细胞中诱导协同作用
Yvonne C F Pang,Susan C Menzies,Laura M Sly
Yvonne C F Pang
Macrophages coordinate cytokine responses by integrating signals from pattern recognition receptors including NOD2 and TLR4. NOD2 detects muramyl dipeptide derived from bacterial peptidoglycan, and TLR4 recognizes lipopolysaccharide in the ...
Mariana Diupotex,Veronica Rojo-Leon,Luis Eduardo Chipres-Naranjo et al.
Mariana Diupotex et al.
Originally characterized for its roles in T-cell activation and adhesion, CD43 is a prominent mucin-like sialoglycoprotein expressed on hematopoietic cells. CD43 is broadly expressed across leukocyte populations, with its levels, molecular ...
Sialylation Modulates Basophil Responsiveness to Galectin-3-dependent Activation [0.03%]
唾液酸化调节基奥菲専对半乳凝素-3依赖性活化的敏感性
Laurent Ehrlich,Donald W MacGlashan Jr,Robert Anthony et al.
Laurent Ehrlich et al.
Basophils secrete histamine and IL-4/13 when co-cultured with human lung adenocarcinoma cells (A549 cells). Previous studies have revealed that this interaction is dependent on Galectin-3 expression on the surface of A549 cells (EC-Gal-3), ...