Importance of antibody validation in detecting cell cycle regulatory protein p16 INK4A by immunohistochemistry on pancreas tissue [0.03%]
抗体验证在免疫组化检测胰腺组织细胞周期调节蛋白p16 INK4A 中的重要性
Jasmine Pipella,Peter J Thompson
Jasmine Pipella
Aims/objective: p16INK4A is a cyclin-dependent kinase inhibitor that plays important roles in pancreatic islet beta-cell maturation, function, and senescence. As staining pattern consistency and reproducibility have been ...
IFNα and bleomycin-induced DNA damage activate distinct stress responses in human islets and induced pluripotent stem cell-derived islet cells [0.03%]
干扰素α和博莱霉素诱导的DNA损伤激活人类胰岛和诱导多能干细胞来源的胰岛细胞中的不同应激反应
Roozbeh Akbari Motlagh,Nayara Rampazzo Morelli,Nicole Alcasid et al.
Roozbeh Akbari Motlagh et al.
Pancreatic β-cells undergo different stress responses during the development of type 1 diabetes (T1D), such as the type I interferon (IFN) response and senescence. Although the IFN response leads to endoplasmic reticulum (ER) stress and ha...
A geometry-informed continuous 3D IEQ framework enables more accurate dose estimation in stem cell-derived islet transplantation [0.03%]
一种基于几何信息的连续3D IEQ框架，可提高干细胞来源胰岛移植剂量估算的准确性
Yu Lu,Jinhui Fang,Zhongyi Jia et al.
Yu Lu et al.
Accurate quantification of islet mass is critical for the preclinical evaluation and therapeutic application of stem cell-derived pancreatic islet organoids. Traditional methods, including Ricordi's islet equivalent (IEQ) approach and its e...
Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation [0.03%]
人和小鼠的再生巨噬细胞可提高胰岛β细胞的存活、功能和增殖能力
Mahdis Monajemi,Alexandra S Craciun,Qing Huang et al.
Mahdis Monajemi et al.
Aims: Type 1 diabetes is caused by immune-mediated destruction of beta cells. Interestingly, individuals with long-standing type 1 diabetes have residual beta cells, suggesting regenerative mechanisms may help beta cell s...
Is the intraportal or renal subcapsular space a preferable site for islet allo- and xeno-transplantation? A brief historical review [0.03%]
肝板与肾被膜下空间：哪种位点更适合作异体和异种胰岛移植？简要历史回顾
Sara De Taeye,Rita Bottino,David K C Cooper
Sara De Taeye
Diabetes mellitus and end-stage renal disease (ESRD) are major causes of morbidity and mortality worldwide.Pancreatic islet transplantation offers potential insulin independence. Different sites and their suitability for islet transplantati...
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway [0.03%]
annexin a1通过pparα/acox1/cyp4a通路调节三酰甘油分解代谢以促进胰岛星状细胞活化
Qing Li,Yan Zhang,Tianpei Yu et al.
Qing Li et al.
Background: Activation of islet stellate cells (ISCs) contributes to islet fibrosis and diabetes progression through excessive extracellular matrix secretion and lipid loss. Annexin A1 (ANXA1) has been reported to modulat...
Differential expression of mitomiRs in pancreatic islet cells associated with maternal protein restriction [0.03%]
与母体蛋白质限制相关的胰岛细胞中线粒体微小RNAs的差异表达
Cecile Jacovetti,Romano Regazzi
Cecile Jacovetti
Objective: Mitochondria are central to energy production and cellular homeostasis. Beyond importing diverse RNAs, they also encode hundreds of their own non-coding RNAs, contributing to a complex and dynamic RNA landscape...
The effect of HNF4α knockout in beta cells is age and sex dependent [0.03%]
HNF4α敲除对胰岛β细胞的影响具有年龄和性别依赖性
Catharina B P Villaca,Viviane R Oliveira,Gustavo J Santos et al.
Catharina B P Villaca et al.
HNF4α is important for beta cells' ability to adequately secrete insulin in response to glucose concentration and endoplasmic reticulum (ER) homeostasis. In humans, HNF4α mutations are responsible for Diabetes mellitus subtype MODY1, whic...
Correction [0.03%]
改正
Published Erratum
Islets. 2025 Dec 31;17(1):2557668. DOI:10.1080/19382014.2025.2557668 2025
Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models [0.03%]
人胰岛模型中芳香烃受体与缺氧诱导因子1α通路的相互作用
Noa Gang,Kyle A van Allen,William G Willmore et al.
Noa Gang et al.
Background: We previously showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD - a persistent organic pollutant) activates the aryl hydrocarbon receptor (AHR) in pancreatic islets. The AHR is known to crosstalk with hypo...