Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway [0.03%]
annexin a1通过pparα/acox1/cyp4a通路调节三酰甘油分解代谢以促进胰岛星状细胞活化
Qing Li,Yan Zhang,Tianpei Yu et al.
Qing Li et al.
Background: Activation of islet stellate cells (ISCs) contributes to islet fibrosis and diabetes progression through excessive extracellular matrix secretion and lipid loss. Annexin A1 (ANXA1) has been reported to modulat...
Differential expression of mitomiRs in pancreatic islet cells associated with maternal protein restriction [0.03%]
与母体蛋白质限制相关的胰岛细胞中线粒体微小RNAs的差异表达
Cecile Jacovetti,Romano Regazzi
Cecile Jacovetti
Objective: Mitochondria are central to energy production and cellular homeostasis. Beyond importing diverse RNAs, they also encode hundreds of their own non-coding RNAs, contributing to a complex and dynamic RNA landscape...
The effect of HNF4α knockout in beta cells is age and sex dependent [0.03%]
HNF4α敲除对胰岛β细胞的影响具有年龄和性别依赖性
Catharina B P Villaca,Viviane R Oliveira,Gustavo J Santos et al.
Catharina B P Villaca et al.
HNF4α is important for beta cells' ability to adequately secrete insulin in response to glucose concentration and endoplasmic reticulum (ER) homeostasis. In humans, HNF4α mutations are responsible for Diabetes mellitus subtype MODY1, whic...
Correction [0.03%]
改正
Published Erratum
Islets. 2025 Dec 31;17(1):2557668. DOI:10.1080/19382014.2025.2557668 2025
Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models [0.03%]
人胰岛模型中芳香烃受体与缺氧诱导因子1α通路的相互作用
Noa Gang,Kyle A van Allen,William G Willmore et al.
Noa Gang et al.
Background: We previously showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD - a persistent organic pollutant) activates the aryl hydrocarbon receptor (AHR) in pancreatic islets. The AHR is known to crosstalk with hypo...
Selina Wrublewsky,Annika Clemenz,Anne S Boewe et al.
Selina Wrublewsky et al.
Pancreatic and duodenal homeobox protein (PDX)1 is a major transcription factor for the regulation of insulin, glucagon and somatostatin (SST) expression. PDX1 is phosphorylated by CK2 and inhibition of this kinase results in an increased i...
Time dynamics of elevated glucose and beta-hydroxybutyrate on beta cell mitochondrial metabolism [0.03%]
高血糖和β-羟基丁酸对β细胞线粒体代谢动力学的影响
Ik Hals,Z Ma,M Kylling et al.
Ik Hals et al.
Chronic hyperglycemia impairs mitochondrial function of beta cells. Changes in mitochondrial function preceding a negative glucose effect have not been fully characterized, nor interactions with ketones. To compare effects on beta cell mito...
The effects of free fatty acid-free bovine serum albumin and palmitate on pancreatic β-cell function [0.03%]
游离脂肪酸、无脂肪酸的牛血清白蛋白以及棕榈酸对胰岛β细胞功能的影响
Katherine Sentjens,Renjitha Pillai,Jamie W Joseph
Katherine Sentjens
Pancreatic β-cells release insulin in response to fluctuations in plasma glucose, amino acids, and free fatty acids (FFA). Clonal cell lines and isolated islets serve as essential early models for studying the impact of nutrients and evalu...
Atorvastatin enhances LDL receptor-mediated LDL-C uptake and modulates PCSK9 protein expression in pancreatic β-cells [0.03%]
阿托伐他汀增强LDL受体介导的LDL-C吸收并调节胰岛β细胞中的PCSK9蛋白表达
Zhiyan Zhang,Huadong Zheng,Lusha Zhang et al.
Zhiyan Zhang et al.
Statins are widely used to treat hyperlipidemia and atherosclerotic cardiovascular diseases (ACVD) by significantly lowering low-density lipoprotein cholesterol (LDL-C) levels. However, their use has been associated with an increased risk o...
Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model [0.03%]
囊性纤维化相关糖尿病( CFRT )雪貂模型胰岛再生过程中的免疫荧光变化
Sawash M Mohammed,Robert N Bone,Jacqueline Del Carmen Aquino et al.
Sawash M Mohammed et al.
Background: Knockout (KO) ferrets with the cystic fibrosis transmembrane conductance regulator (CFTR) exhibit distinct phases of dysglycemia and pancreatic remodeling prior to cystic fibrosis-related diabetes (CFRD) devel...