Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons [0.03%]
氨肽酶通过增强糖酵解刺激感觉神经元组蛋白乳酸化参与神经病理性疼痛产生
Yu-Tao Deng,Longfei Ma,Yixiao Mei et al.
Yu-Tao Deng et al.
The genesis of neuropathic pain after peripheral nerve injury is associated with changes in gene expression and cell metabolism in sensory neurons and the release of inflammatory cytokines. Here, we connected glycolytic metabolism induced b...
Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation [0.03%]
胞内和核CXCR4信号促进晚期红细胞生成和脱核
Julia Christine Gutjahr,Elin Hub,Caroline Amy Anderson et al.
Julia Christine Gutjahr et al.
The chemokine CXCL12 signals through its receptor CXCR4 to induce the migration of all leukocyte types and multiple other cell types. Here, we report that CXCR4 is expressed in mouse erythroblasts, the bone marrow erythroid precursors, in w...
Sweet structures [0.03%]
甜结构
John F Foley
John F Foley
The cryo-EM structures of human sweet taste receptors reveal the molecular basis of sweet taste detection.
Decoding extracellular matrix-lysosome cross-talk and its implications for neurodegenerative diseases [0.03%]
解读细胞外基质溶酶体交叉信号及其对神经退行性疾病的影响
Qinghu Yang,Huan Ma,Liang Yang et al.
Qinghu Yang et al.
Lysosomes are versatile organelles that play pivotal roles in cellular recycling and signal transduction. They are crucial for the autophagic degradation and recycling of macromolecules, which facilitates the efficient turnover of cellular ...
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation [0.03%]
一种体内筛选鉴定出多种区域可以作为诺特定点蛋白酶剪切的力依赖性开关
Frederick C Baker,Jacob Harman,Trevor Jordan et al.
Frederick C Baker et al.
Notch proteins are single-pass transmembrane receptors activated by sequential extracellular and intramembrane cleavages to release the cytosolic domains that function as transcription factors. Transmembrane ligands of the Delta/Serrate/LAG...
Nociceptor-specific signaling of the receptor guanylyl cyclase Npr2 contributes to acute and persistent pain [0.03%]
受体鸟苷酸环化酶Npr2的痛觉感受器特异性信号传导有助于急性疼痛和持续性疼痛
Hannah Gerninghaus,Jörg Isensee,Lea Kennel et al.
Hannah Gerninghaus et al.
Natriuretic peptide receptor 2 (Npr2; also termed guanylyl cyclase B) is a transmembrane guanylyl cyclase that is highly abundant in nociceptors. Here, we investigated the role of production of cyclic GMP (cGMP) by Npr2 in pain processing. ...
The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RB [0.03%]
E3连接酶TRIM21通过下调TAp63α并解离IL20RB促进胰腺导管腺癌进展
Zejiao Li,Fengwei Gao,Xuesha Liu et al.
Zejiao Li et al.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor and frequently has mutations in the transcription factor p53. TAp63α is a member of the p53 protein family that is generally tumor suppressive in various other p53-mutant or p5...
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis [0.03%]
SMAD2 S-棕榈酰化促进其连接区磷酸化和小鼠多发性硬化模型中TH17细胞分化
Mingming Zhang,Tao Yu,Yinong Liu et al.
Mingming Zhang et al.
The transcriptional regulators SMAD2 and SMAD3 share the same primary signaling pathway in response to the cytokine TGFβ. However, whereas SMAD2 stimulates the differentiation of naive CD4+ T cells into proinflammatory T helper 17 cells (T...
Lulled to sleep by ROS [0.03%]
ROS催眠入睡
Wei Wong
Wei Wong
ROS generated by sleep-promoting neurons tracks the need for sleep and initiates sleep.
YAP controls cell migration and invasion through a Rho GTPase switch [0.03%]
YAP通过Rho GTP酶开关控制细胞迁移和侵袭
Sagar R Shah,Chunxiao Ren,Nathaniel D Tippens et al.
Sagar R Shah et al.
Delineating the mechanisms that control the movement of cells is central to understanding diverse physiological and pathophysiological processes. The transcriptional coactivator YAP is important during development and associated with cancer...