A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging [0.03%]
ADAR诱导的A至I RNA编辑减少通过破坏Pumilio介导的MAPK信号抑制作用促进肠干细胞衰老
Qian Zhang,Yuedan Zhu,Yi Chen et al.
Qian Zhang et al.
Aging impairs intestinal stem cell (ISC) function, disrupting epithelial homeostasis and regenerative repair. Loss of ISC quiescence promotes intestinal dysfunction and contributes to organismal aging. Here, we report an epitranscriptomic m...
Wei Wong
Wei Wong
Chronic stress in mice causes anxiety and hyperglycemia by inducing senescence in amygdala astrocytes.
NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrine [0.03%]
NDRG1在癌症中的表达使DNA损伤修复产生依赖并使其具有喹吖因敏感性
Garik V Mkrtchyan,Alexander Veviorskiy,Zarah G Meisen et al.
Garik V Mkrtchyan et al.
Cancer cells exploit DNA repair to overcome damage and errors induced by rapid proliferation and repressed checkpoints. Thus, the loss of one DNA repair protein can make tumors more susceptible to inhibition of other repair pathways. Here, ...
Design of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects [0.03%]
一种新型致幻曲帕扎因类似物的设计及其潜在的治疗效果和较少副作用研究
Jason Younkin,Ajay H Bansode,Somdatta Saha et al.
Jason Younkin et al.
Psychedelics that target serotonin 2A receptors (5-HT2ARs) hold therapeutic promise for neuropsychiatric disorders but are often hindered by off-target actions. The 5-HT2AR agonist quipazine also activates 5-HT3R, which contributes to undes...
The E3 ligase TRIM13 restrains LPS-induced inflammation by reducing STIM1 abundance and the IRE1α-dependent unfolded protein response [0.03%]
E3连接酶TRIM13通过减少STIM1的含量和IRE1α依赖性的未折叠蛋白反应而抑制LPS诱导的炎症反应
Zheng Li,Xuelian Li,Zhou Yu et al.
Zheng Li et al.
Recognition of the bacterial product lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) initiates inflammatory responses. The unfolded protein response (UPR) elicited by endoplasmic reticulum (ER) stress can strengthen TLR4-dependent i...
Leslie K Ferrarelli
Leslie K Ferrarelli
A molecular glue degrader tackles mutant BRAF in drug-resistant colorectal cancer by disrupting mRNA splicing.
Glycerol 3-phosphate activates lipid metabolism through GATOR2-dependent regulation of mTORC1 [0.03%]
甘油-3-磷酸通过活化GATOR2调控mTORC1促进脂质代谢
Hyokjoon Kwon,Sayaka Yamada,Lingqiong Meng et al.
Hyokjoon Kwon et al.
Triglycerides can be formed by fatty acid esterification of glycerol 3-phosphate (G3P) and by de novo lipogenesis (DNL). We identified G3P as a stimulus that activated mTORC1, a nutrient-sensing protein complex that promotes DNL in the live...
Loss of the kinases TBK1 and IKKε sensitizes target cancer cells to T cell killing through an IFN-γ-mediated inflammatory death program [0.03%]
TBK1和IKKε的丧失通过IFN-γ介导的炎症性细胞死亡程序使肿瘤靶细胞对T细胞杀伤敏感化
Nicholas D Sun,Allison R Carr,Erica N Krogman et al.
Nicholas D Sun et al.
Cytotoxic T cells produce the cytokine interferon-γ (IFN-γ). We sought to determine whether IFN-γ directly kills target cells and found that T cells used IFN-γ to kill murine melanoma cells lacking the kinases TBK1 and IKKε. In the abs...