GNAI1 missense mutations associated with a neurodevelopmental syndrome modify Gαi1 function [0.03%]
GNAI1错义突变与一种神经发育障碍通过改变Gαi1功能致病
Marlene Fritsche,Gaia Picozzi,Tomas Nyman et al.
Marlene Fritsche et al.
G protein-coupled receptors (GPCRs) play key roles in neurodevelopment by regulating excitatory and inhibitory neuronal pathways. The G protein subunit Gαi1 is a downstream effector of inhibitory GPCR signaling, and the gene encoding it (G...
Local traveling waves of cytosolic Ca2+ elicited by defense signals or wounding are propagated by distinct mechanisms in Arabidopsis [0.03%]
拟南芥中由防御信号或伤害引起的细胞质Ca2+局部旅行波通过不同的机制传播
Weiwei Zhang,Nilay Kumar,Jessica R Helwig et al.
Weiwei Zhang et al.
Cytosolic calcium ion (Ca2+) signatures with specific spatiotemporal patterns play crucial roles in plant responses to biotic and abiotic stresses. The perception of microbe- or damage-associated molecular patterns (MAMPs or DAMPs, respecti...
Waving hello to pathogens: The dynamics of the spread of plant MAMP-triggered Ca2+ signaling [0.03%]
挥手告别病原体：植物MAMP触发的Ca2+信号传播的动力学
Simon Gilroy
Simon Gilroy
Waves of Ca2+ signals rapidly propagate throughout a plant to help integrate responses to stimuli as diverse as wounding, heat stress, and pathogen attack. In this issue of Science Signaling, Zhang et al. show that bacterial elicitors and p...
p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1-driven ovarian cancers [0.03%]
P16表达可使周期素E1驱动的卵巢癌对CDK2抑制剂敏感
Chance C Sine,Lotte P Watts,Brianna Fernandez et al.
Chance C Sine et al.
Blocking the cell cycle is a promising avenue for cancer therapy, with cyclin-dependent kinase 2 (CDK2) emerging as a key target. However, in multiple cell types, the activities of CDK4 and CDK6 (CDK4/6) compensate for CDK2 inhibition and s...
Wei Wong
Wei Wong
Stem cells in hair follicles can be activated after skin injury by fatty acids released from adipocytes.
SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR-mutant lung cancer [0.03%]
SOS1抑制可抑制奥希替尼耐药性的产生以使EGFR突变型肺癌持久应答
Brianna R Daley,Patricia L Theard,Jacob M Hughes et al.
Brianna R Daley et al.
Osimertinib is the mainstay of therapy for patients with non-small cell lung cancer (NSCLC) driven by the receptor tyrosine kinase (RTK) EGFR. In most patients, however, therapeutic pressure promotes RTK-dependent mechanisms that support tu...
CoDIAC: A comprehensive approach for interaction analysis provides insights into SH2 domain function and regulation [0.03%]
一种全面的交互作用分析方法CoDIAC为SH2结构域功能和调控提供新的见解
Alekhya Kandoor,Gabrielle Martinez,Julianna M Hitchcock et al.
Alekhya Kandoor et al.
Protein domains are conserved structural and functional units that serve as the building blocks of proteins. Through evolutionary expansion, domain families are represented by multiple members in diverse configurations with other domains, e...
IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation [0.03%]
放射线照射后，I型干扰素信号增强唾液腺干细胞和祖细胞的活性
Davide Cinat,Ryan van der Wal,Mirjam Baanstra et al.
Davide Cinat et al.
The goal of radiotherapy in cancer treatment is to maximize DNA damage in tumors while minimizing harm to surrounding healthy tissues, especially to stem and progenitor cells essential for tissue regeneration and organ function. Here, we in...
Yoshiaki Sato,Jian Yu
Yoshiaki Sato
Innate immune signaling is important for tissue regeneration. In this issue of Science Signaling, Cinat et al. report that a cell-intrinsic type I interferon (IFN-I) response drives salivary gland organoid regeneration after radiation and t...
CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation [0.03%]
CSF1R-CAR T细胞能够诱导CSF1R信号通路并促进靶点细胞增殖
Aurora Callahan,Xinyan Zhang,Amber Wang et al.
Aurora Callahan et al.
Chimeric antigen receptor (CAR) T cells have demonstrated unprecedented success in treating relapsed or refractory blood cancers. Previous studies of the mechanisms underlying the interactions and responses of CAR T cells and their targets ...