A MATLAB Algorithm to Automatically Estimate the QT Interval and Other ECG Parameters and Validation Using a Machine Learning Approach in Congenital Long-QT Syndrome [0.03%]
一种自动估算先天性长QT综合症心电图QT间期和其他参数的MATLAB算法及机器学习方法验证
Elinor Tzvi-Minker,Sven Dittmann,Corinna Rickert et al.
Elinor Tzvi-Minker et al.
Myocardial repolarization and QT duration are crucial markers for diagnosis and monitoring of congenital long QT syndrome (LQTS). Here we present a novel algorithm to automatically estimate the QT interval based on Lepeschkin's tangent meth...
Bayesian Reanalysis of Mortality Outcomes in Cardiovascular Trials: Addressing Limitations of Traditional Significance Testing [0.03%]
心血管试验中死亡结局的贝叶斯再分析：解决传统显著性检验的局限性
Gisèle Nakhlé,Jean-Claude Tardif,Anick Dubois et al.
Gisèle Nakhlé et al.
The American Statistical Association (ASA) has cautioned against overreliance on p-values, noting that rigid thresholds (e.g., p < 0.05) can obscure statistical uncertainty and clinical meaning. This study illustrates how Bayesian methods c...
Use of Sirolimus, an mTOR Inhibitor, to Treat Sarcoidosis in Multiple Systems [0.03%]
使用雷帕霉素治疗多系统 sarcoidosis
Liam McGuire,Roxxy Brown,Angeliki Asimaki
Liam McGuire
Sarcoidosis is a heterogenous, multi-systemic granulomatous disease with highly variable incidence (5-40/100,000) and a disproportionate mortality burden in those presented with pulmonary fibrosis or cardiac involvement. Yet, current manage...
Fumarate Signaling in Cardiovascular Disease: Therapeutic Potential and Pathologic Pitfalls of DMF/MMF and FH1 Deficiency [0.03%]
富马酸信号与心血管疾病：DMF/MMF和FH1缺陷的治疗潜力及病理陷阱
Xi-Long Zheng,Hao Yin
Xi-Long Zheng
Fumarate is increasingly recognized as a metabolic signal with dual effects in cardiovascular disease. Pharmacologic doses of dimethyl fumarate (DMF) and its metabolite monomethyl fumarate (MMF) transiently activate Nrf2 and HCAR2 pathways,...
Systemic Interactions in HFpEF: A Multiorgan Perspective on Pathways and Therapeutic Targets [0.03%]
HFpEF的系统交互作用：多器官视角下的途径与治疗靶点
Xinxin Cui,Yuxin Hu,Yunwei Xu et al.
Xinxin Cui et al.
Heart failure with preserved ejection fraction (HFpEF) is a complex multisystem syndrome with increasing prevalence in aging and metabolically compromised populations. In addition to diastolic dysfunction, HFpEF involves metabolic abnormali...
Molecular Pathways of Endothelial Dysfunction Induced by Chronic Social Stress and Therapeutic Interventions [0.03%]
慢性社交压力诱导的内皮功能障碍分子途径及其治疗干预措施
Imran Ali,Shoaib Muhammad,Lingxi Wei et al.
Imran Ali et al.
Chronic social stress is increasingly recognized as a significant contributor to endothelial dysfunction, a key precursor to various cardiovascular diseases. This review endeavors to explain the intricate molecular pathways underlying endot...
Study of the L-Carnitine Effect on Myocardial Bioelectrical Activity by Microelectrode Arrays and Artificial Intelligence Application [0.03%]
L-肉碱对心肌生物电活动影响的微电极阵列及人工智能应用研究
Elena Kotikhina,Denis Karchkov,Viktor Moskalenko et al.
Elena Kotikhina et al.
The article presents the results of applying artificial intelligence algorithms to analyze multichannel electrograms of bioelectrical activity registered by microelectrode arrays from myocardium of isolated rat hearts under the influence of...
Network Medicine-Based Repurposing of Mesalazine for Atherosclerosis Treatment [0.03%]
基于网络药理学的美沙拉嗪治疗动脉粥样硬化的老药新用研究
Jianhui Jiang,Ziling Zheng,Chongbo Jiang et al.
Jianhui Jiang et al.
Atherosclerosis remains a leading cause of cardiovascular disease and mortality worldwide, despite advancements in statin therapies. Here, we aimed to identify potential anti-atherosclerosis drugs by an integrated approach combining network...
Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death [0.03%]
循环死亡供者心脏捐献的体外灌注心肌保护研究进展
Lars Saemann,Kristin Wächter,Anne Großkopf et al.
Lars Saemann et al.
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirc...
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation [0.03%]
缺氧通过ACSL4乳酰化促进铁死亡加重心肌缺血再灌注损伤
Jiannan Lv,Mingnan Yin,Hongwen Jin
Jiannan Lv
Myocardial ischemia/reperfusion injury (MIRI) worsens ischemic damage, with ferroptosis as a key mediator of this iron-dependent cell death. Lactylation, a novel epigenetic modification, remains poorly understood in MIRI-associated ferropto...