Epigenetic Control of Cardiomyocyte Necrosis: Targeting ACSS2 to Attenuate Myocardial Ischemia/Reperfusion Injury [0.03%]
表观遗传调控心肌细胞坏死：靶向ACSS2减轻心肌缺血/再灌注损伤
Brijesh Sathian,Javed Iqbal,Syed Muhammad Ali
Brijesh Sathian
Single-Cell Sequencing Identifies the Crucial Role of Mitochondrial Fission-Fusion Imbalance in Heart Failure Progression [0.03%]
单细胞测序揭示线粒体分裂/融合失衡在心力衰竭进展中的关键作用
Tao He,Jianmei Sha,Yuxin Hu et al.
Tao He et al.
The heart grows in response to both pathological and physiological stimuli. Pathological hypertrophy often leads to cardiomyocyte loss and heart failure (HF), whereas physiological hypertrophy paradoxically protects the heart. Comparing the...
From Mechanisms to Diseases: The Succinate-GPR91 Axis in Cardiometabolic Diseases [0.03%]
从机制到疾病：琥珀酸-GPR91轴在心血管代谢性疾病中的作用
Yumeng Jia,Lei Wang
Yumeng Jia
Cardiometabolic diseases (CMD) encompass a cluster of cardiovascular disorders primarily driven by metabolic dysregulation, such as obesity-associated cardiomyopathy, hypertensive heart disease, and diabetic cardiomyopathy. The pathogenesis...
Nanoparticles For Rescue: Innovative Therapeutic Strategy For Cardiac Repair After Myocardial Infarction [0.03%]
用于心脏修复的纳米颗粒创新治疗策略——心肌梗死后的救援疗法
Yi-An Mao,Rui Wang,Xiaozhou Shi et al.
Yi-An Mao et al.
Myocardial infarction (MI), is a leading cause of global mortality, marked by cardiomyocyte death. This takes place as a result of ischemic injury, the detrimental impacts of oxidative stress, and inflammatory responses. Conventiona pharmac...
Enhancement of the Mayo Clinic HCM Genotype Predictor Score with Addition of Cardiac Magnetic Resonance Imaging [0.03%]
卡巴斯基磁共振成像增强型梅奥诊所肥厚性心肌病基因预测评分
Iuri Ferreira Felix,Vanessa Karlinski Vizentin,Mateo Alzate-Aguirre et al.
Iuri Ferreira Felix et al.
This study aimed to evaluate the role of cardiac magnetic resonance (CMR) in updating The Mayo Clinic Hypertrophic Cardiomyopathy (HCM) Genotype Predictor Score. We performed an analysis of 175 HCM patients with an echocardiogram, CMR, and ...
Machine Learning-Driven Identification of Blood-Based Biomarkers and Therapeutic Agents for Personalized Ischemic Stroke Management [0.03%]
基于机器学习的血液生物标志物和个性化缺血性卒中治疗药物的识别
Jing Liu,Congxia Bai,Haitao Yang et al.
Jing Liu et al.
Ischemic stroke (IS) is the most common subtype of stroke. However, reliable blood biomarkers for early diagnosis remain unavailable. This study developed a predictive model based on peripheral blood (PB) biomarkers. PB samples from two ind...
Identification of Candidate Inflammatory-Nutritional Blood Biomarkers for Cachexia and Muscle Depletion in Polish Chronic Heart Failure Patients [0.03%]
波兰慢性心力衰竭患者恶病质和肌肉减少症候选炎症-营养血液生物标志物的鉴定
Angelika Szymczak,Aneta Skwarek-Dziekanowska,Grzegorz Sobieszek et al.
Angelika Szymczak et al.
Cachexia is a complex syndrome often affecting chronic heart failure (CHF) patients, characterized by muscle wasting and systemic inflammation. Early detection is crucial for improving patient outcomes. This study evaluated candidate inflam...
Copper Homeostasis and Cuproptosis As Potential Intervention Strategy in Atherosclerosis [0.03%]
铜稳态和铜死作为动脉粥样硬化潜在的干预策略
Jingchun Xie,Liuyan Xin,Qi Jin et al.
Jingchun Xie et al.
Atherosclerosis (AS) is a vascular disorder characterized by lipid accumulation, fibrous tissue proliferation, and calcium deposition in the intima, contributing significantly to the mortality associated with cardiovascular disease, and the...
The Diagnostic Significance of Circulating Eicosanoid in Patients with Hypertrophic Cardiomyopathy [0.03%]
肥厚性心肌病患者循环白三烯的诊断意义
Yue Zhang,Xinyu Liu,Zhongze Zhang et al.
Yue Zhang et al.
Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases. Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were p...