Huan Zhang,Chen Liao
Huan Zhang
In this issue of Cell Host & Microbe, Liu et al. provide a roadmap for decoding the gut microbiome's functional dark matter through a structural atlas of gut phage and bacterial proteins, validating structure-guided functions from endolysin...
Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase [0.03%]
人类流感A（H3N2）病毒神经氨酸酶60年抗原进化历程的分子基础
Miruna E Rosu,Kim B Westgeest,Miranda de Graaf et al.
Miruna E Rosu et al.
Human influenza A viruses escape antibody-mediated immunity through changes in the hemagglutinin (HA) and neuraminidase (NA) glycoproteins. HA antigenic evolution has been studied extensively, with more recent interest in NA due to its impo...
Viral theft of light: A cyanophage protein dismantles cyanobacterial photosynthesis to accelerate infection [0.03%]
病毒窃光：一种青噬菌体蛋白拆解蓝藻光合作用以加速感染
Shiwei Xiao,Qinglu Zeng
Shiwei Xiao
Auxiliary metabolic genes, acquired by cyanobacterial viruses (cyanophages) from their hosts, are thought to manipulate host metabolism during infection. A recent study by Nadel et al. performed in vivo experiments to reveal how cyanophages...
Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis [0.03%]
黏液化红球菌膜囊泡通过稳定易变铁以缓解UVB诱导的铁死亡
Siyuan Fan,Xinyue Cai,Weiqi Wang et al.
Siyuan Fan et al.
Ultraviolet irradiation, particularly ultraviolet B (UVB), damages keratinocytes, potentially causing actinic cheilitis. Commensal bacteria help maintain barrier function and protect the host. However, it is unclear if commensal bacteria ca...
UBE2O-mediated monoubiquitination licenses NLRP6 inflammasome activation in the intestine [0.03%]
UBE2O介导的单泛素化激活肠道中的NLRP6炎性小体
Decai Wang,Xuequn Chen,Kaiwen Sui et al.
Decai Wang et al.
The NLRP6 inflammasome in intestinal epithelial cells (IECs) is a key sentinel of enteric pathogens, yet its activation mechanism remains enigmatic. Here, we identify monoubiquitination as a critical post-translational switch for NLRP6 infl...
Gut-derived succinic acid potentiates high-altitude-related spermatogenesis dysfunction [0.03%]
源自肠道的延胡索酸可加剧高原地区相关生精功能障碍
Jianchun Zhou,Cheng Lu,Shijie Tang et al.
Jianchun Zhou et al.
Exposure to high altitude (HA) is linked to male spermatogenesis impairment and microbial imbalance; however, the association and underlying mechanisms remain unexplored. Herein, we demonstrate that HA-induced gut microbiota changes in huma...
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity [0.03%]
肠道氨基酸的微生物代谢调控癌症进程和抗肿瘤免疫反应
Shanshan Qiao,Ting-Ting Li,Mingeum Jeong et al.
Shanshan Qiao et al.
The human microbiota modulates cancer progression through largely unexplored mechanisms. Defining causal pathways is essential for monitoring and fine-tuning the microbiota to improve cancer treatment. Given that amino acid (aa) metabolism ...
A CLOCK-targeting lncRNA induces trained immunity against tuberculosis [0.03%]
一种调控钟基因的长链非编码RNA可诱导针对结核分枝杆菌感染的获得性抵抗力
Shanshan Yu,Qiyao Chai,Zhe Lu et al.
Shanshan Yu et al.
Trained immunity confers innate immune memory via metabolic and epigenetic reprogramming, yet the intercellular mediators regulating this process in host defense remain largely elusive. Here, through plasma exosomal profiling of tuberculosi...
Functional immune responses induced by a capsid assembly modulator in chronic hepatitis B virus-infected humanized mice [0.03%]
一种衣壳组装调节剂在慢性乙肝病毒人源化小鼠中的功能免疫反应作用研究
Priyanka Fernandes,Yidan Wang,Jean-Marc Doisne et al.
Priyanka Fernandes et al.
Current treatment strategies for hepatitis B virus (HBV) are lifelong and rarely curative. Finite therapeutic strategies aim to restore efficient immune responses in chronically infected patients for functional cures. Here, we investigate t...
A gut-secreted histidine methyltransferase enforces cross-kingdom catalytic antifungal defense [0.03%]
一种肠道分泌组氨酸甲基转移酶介导跨王国催化的抗真菌防御作用
Hong Bao,Chen Yang,Panrui Zhang et al.
Hong Bao et al.
Mucosal immunity deploys diverse defenses against fungal pathogens, yet the evolution of fungal resistance demands new antifungal strategies. Here, we uncover that intestinal epithelial cells secrete the host histidine methyltransferase MET...