UBE2O-mediated monoubiquitination licenses NLRP6 inflammasome activation in the intestine
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The NLRP6 inflammasome in intestinal epithelial cells (IECs) is a key sentinel of enteric pathogens, yet its activation mechanism remains enigmatic. Here, we identify monoubiquitination as a critical post-translational switch for NLRP6 inflammasome activation.... ...
