A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota [0.03%]
保守的适配器协调肠道细菌Bacteroidota中协同分泌的类型VI效应物
Weixun Li,Shuaining Zheng,Xiaoning Xu et al.
Weixun Li et al.
Interbacterial competition is crucial for shaping microbial communities and is often mediated by type VI secretion systems (T6SSs) that inject effectors into competing bacteria. T6SS effectors are released via structural proteins such as Vg...
Lost and found: Reconstituting PRR immune function through co-receptor transfer [0.03%]
失而复得：通过协同受体转移重构PRR免疫功能
Francisco M Gordillo-Cantón,Isabel Monte
Francisco M Gordillo-Cantón
Plant immune receptors hold great promise for engineering broad-spectrum disease resistance, but their effectiveness is very limited by restricted taxonomic functionality (RTF). In this issue of Cell Host & Microbe, Zhang et al. reveal that...
Misfortunes never come singly: Microbial metabolites link heart failure and chronic kidney disease [0.03%]
祸不单行：微生物代谢产物链接心力衰竭和慢性肾病
Jingyuan Fu,Nine V A M Knoers
Jingyuan Fu
Heart failure is life threatening and common in chronic kidney disease patients. In this issue,1 Zheng et al. report that toxin-generating E. coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk with k...
Jinglin Hou,Xinyang Song
Jinglin Hou
In this issue of Cell Host & Microbe, Czauderna et al. reveal that unsaturated long-chain fatty acids (uLCFAs) accumulate in the gut during immune activation, yet are toxic to commensals, notably Blautia producta. Symbiont-encoded oleate hy...
Simona Seizova,Christopher J Tonkin
Simona Seizova
In recent papers published in Cell and Cell Host and Microbe, Marzook et al. and Huang et al. investigate how Cryptosporidium, an enteric parasite, can acquire nutrients from its host and deals with potentially toxic products. These studies...
Evie R Hodgson,Diana Stojanovski
Evie R Hodgson
In a recent Science paper, Medeiros et al. describe how infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma parasites for folate, an essential vitamin for DNA synthesis. This metabolic immunity strategy transform...
Moshe Alon,Omri M Finkel
Moshe Alon
Despite being an essential part of terrestrial ecosystems for ∼400 million years, the microbiome of wood is surprisingly underexplored. In a recent issue of Nature, Arnold et al. make a long overdue dive into the unique and surprisingly di...
Antonio Lavecchia
Antonio Lavecchia
In a recent paper published in Cell, Krishnan et al. present a generative deep learning platform that combines graph neural network (GNN)-based fragment screening with de novo molecular design to identify NG1 and DN1, two lead compounds wit...
The HY5-NPR1 module governs light-dependent virulence of a plant bacterial pathogen [0.03%]
HY5-NPR1模块调控植物细菌病原菌的光依赖性致病性
Pengtao Liu,Zhao Zhao,Yaqi Tang et al.
Pengtao Liu et al.
Published Erratum
Cell host & microbe. 2025 Oct 7:S1931-3128(25)00382-8. DOI:10.1016/j.chom.2025.09.016 2025
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation [0.03%]
肠道微生物组产生的尸胺介导免疫代谢重编程调控结肠炎症
Rodrigo de Oliveira Formiga,Qing Li,Yining Zhao et al.
Rodrigo de Oliveira Formiga et al.
Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes monocyte-macrophage immunometabolism in a context- and concentration-d...