Wei-Jia Zhang,Aoran Hu,Ziheng Wu et al.
Wei-Jia Zhang et al.
Microorganisms dominate life in the hadal zone, yet extreme sampling difficulty and low biomass have precluded characterization of their in situ activities. Here, we analyze microbiome samples collected from hadal seawaters via in situ filt...
Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor [0.03%]
工程化口腔共生纳米疫苗以激活针对肿瘤的粘膜-全身免疫级联反应
Zirong Dong,Shuyan Li,Yuning Wei et al.
Zirong Dong et al.
Mucosal immunity-the body's frontline defense, harboring 80% of the body's immune cells-represents a potent yet underexploited avenue for cancer vaccination. Here, we developed an oral biohybrid vaccine platform by integrating tumor antigen...
Andrew T Nishimoto,Juan C Ortiz-Marquez,Michelle R Scribner et al.
Andrew T Nishimoto et al.
Antibiotic resistance poses significant challenges, yet pathogen adaptation pathways vary. To determine how host environments affect adaptation, we experimentally evolved Streptococcus pneumoniae in mice subjected to antibiotics in the cont...
Helena Shomar,Marie Guillaume,Florian Tesson et al.
Helena Shomar et al.
Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some natural products protect bacteria from phages, the prevalence and diversity of chemical anti-...
Weishu Zhao,Jing Wang,Chuanxu Chen et al.
Weishu Zhao et al.
Plate subduction creates unique topographic features in hadal trenches, yet their influence on microbial ecosystems and the global ocean remains unclear. Here, we conducted a topography-targeted investigation across 6-11 km of water depth w...
Alex Hong,Miaoxi Liu,Alexis Truta et al.
Alex Hong et al.
Anti-bacteriophage systems such as restriction-modification and CRISPR-Cas have DNA substrate specificity mechanisms that enable the identification of invaders. How Gabija, a highly prevalent nuclease-helicase antiphage system, limits phage...
Following Ariadne's thread through microbiome-based biomarker discovery in CRC [0.03%]
基于微生物组的结直肠癌生物标志物发现方法研究
Jason Xing Kang,Sunny Hei Wong
Jason Xing Kang
Colorectal cancer (CRC) carries a microbial fingerprint, but how does it generalize across age, geography, and sequencing platforms? In this issue of Cell Host & Microbe, Pekel and colleagues stitch together large-scale stool and tumor data...
Oksana Kotovskaya,Artem Isaev
Oksana Kotovskaya
DNA repair proteins are repeatedly repurposed for antiviral immunity. In this issue of Cell Host & Microbe, Bell et al. utilized phylogenetic reconstruction of the evolutionary routes of the YprA repair helicase; their study revealed the br...
Sweet and sour immunity: The two faces of citrus defense in Huanglongbing [0.03%]
酸甜苦辣皆免疫：黄龙病下的柑橘抗病性两面性
Chien-Yu Huang
Chien-Yu Huang
Citrus Huanglongbing is a devastating citrus disease caused by the bacterium Candidatus Liberibacter asiaticus (CLas). Two papers in this issue of Cell Host & Microbe reveal that CLas suppresses plant salicylic acid defense. Paradoxically, ...
Lan Zhang,Xianbin Tian,Meng Wu
Lan Zhang
In a recent Immunity paper, Lobel and colleagues integrate cross-cohort human microbiome meta-analyses with mechanistic studies in mice to uncover a dietary sulfur amino acid-microbiota-immune axis that enhances anti-tumor immunity. Sulfur ...