The female urogenital microbiome: Ecological insights, therapeutic strategies, and molecular mechanisms [0.03%]
Jelle Dillen,Caroline E M K Dricot,Vanessa Croatti et al.
Jelle Dillen et al.
Microbiome-based interventions for female urogenital health have gained attention, particularly in strategies aimed at restoring lactobacilli dominance to reduce infection and improve reproductive outcomes. These approaches include defined ...
Aline Potiron,Jolien C Francken,Sahar El Aidy
Aline Potiron
Translation in microbiome science is limited by static concepts of health that obscure dynamic host-microbe processes. We propose adaptive coherence: the capacity of host-microbiome systems to sustain integrated function through reorganizat...
Janneke H H M van de Wijgert
Janneke H H M van de Wijgert
Bacterial vaginosis remains prevalent and often refractory or recurrent. In this issue, Bloom et al. and Potloane et al. report clinical trial results evaluating three vaginal live biotherapeutic products containing different Lactobacillus ...
Megan Wang,Samuel H Sternberg
Megan Wang
In this issue, Tak et al. report that bacteria produce 2',3'-cGAMP, a signaling molecule once considered unique to metazoans. This cyclic dinucleotide activates a SAVED-domain effector that polymerizes into membrane-disrupting filaments, in...
George S Deepe Jr
George S Deepe Jr
Neutrophils require a considerable amount of glucose to combat Candida albicans infections. However, in tissues, glucose can be depleted due to fungal utilization. In this issue, Choi et al. report that, in glucose-deprived environments, ne...
Jaeden D Flury,Drew J Schwartz
Jaeden D Flury
Gut-derived bacterial DL-endopeptidase may confer protection from late onset sepsis (LOS) in preterm infants. In this issue of Cell Host & Microbe, Shen et al. identified delayed gut microbiome development in preterm infants as a risk facto...
Huiqi Wang,Shijie Cao
Huiqi Wang
In the current issue of Cell Host & Microbe, Sánchez-Martínez et al. demonstrate that oral and small-intestine small intestinal bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergen...
Dena Lyras,Wing Hei Chan,Helen E Abud
Dena Lyras
The colonic epithelium is organized in functional regions and interacts with an abundant microbial community. In Cell, Rispal et al. discover that regionalization depends on microbes, with proximal identity regulated by microbial nicotinic ...
Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4 [0.03%]
宿主-微生物DPP4异构酶在短双歧杆菌加剧心脏缺血再灌注损伤中的作用
Junxia Zhang,Changyun Liu,Yupeng Wang et al.
Junxia Zhang et al.
Ischemia/reperfusion (I/R) injury is a key driver in cardiomyocyte loss and cardiac dysfunction in ischemic heart disease. Here, we uncover a previously unrecognized gut microbiota-mediated mechanism that contributes to myocardial I/R injur...
Soil microbial diversity associates with lower prevalence of human bacterial pathogens across global soils [0.03%]
土壤微生物多样性与全球土壤中的人类细菌病原体较低的流行率相关性研究
Chao Xiong,Manuel Delgado-Baquerizo,Jinsong Liang et al.
Chao Xiong et al.
Soil-inhabiting pathogens threaten human health, but their biogeography and associations with soil biodiversity remain poorly understood. Here, we present global patterns of dominant human bacterial pathogens by integrating 1,602 soil metag...