'Insane in the membrane': 2',3'-cGAMP triggers filamentous phage defense
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In this issue, Tak et al. report that bacteria produce 2',3'-cGAMP, a signaling molecule once considered unique to metazoans. This cyclic dinucleotide activates a SAVED-domain effector that polymerizes into membrane-disrupting filaments, inducing abortive in... ...
