TRPV1 from the TRP family: Structure, function, implication in autoimmune diseases and potential therapies [0.03%]
瞬时受体电位香草素亚型1的研究进展及其在自身免疫病治疗中的潜力
Typhaine Bejoma,Yanna Pan,Qingjie Zhao
Typhaine Bejoma
The transient receptor potential vanilloid type 1 (TRPV1) channel, a member of the TRP ion channel family, plays a crucial role in both physiological and pathological processes. This review provides an overview of the structure, biological ...
An update on regulation of the polymodal TRPV4 channel by protein phosphorylation [0.03%]
TRPV4通道的多功能调节蛋白磷酸化的最新研究动态更新
Aravind Parthasarathy,David X Zhang
Aravind Parthasarathy
TRPV4 is a polymodal Ca2+-permeable cation channel activated by diverse stimuli via various pathways and has been one of the difficult membrane proteins to comprehend, like other TRP channels. However, a broad range of functions and patholo...
TRPV4 regulates intraocular pressure through trabecular meshwork contractility and fibrosis [0.03%]
TRPV4通过小梁网收缩和纤维化调节眼内压
Juš Žavbi,Sarah N Redmon,David Križaj
Juš Žavbi
Intraocular pressure (IOP) is dynamically regulated by the contractility and viscoelasticity of the trabecular meshwork (TM). Two recent studies identified the polymodal cation channel TRPV4 as a central mechanosensor that integrates mechan...
Association of the chemerin-CMKLR1 with atrial potassium current dysregulation and atrial fibrillation in obese mice [0.03%]
趋化因子C型凝集素配基2与肥胖小鼠心房钾电流异常及心房颤动的关系研究
Yating Chen,Bin Li,Jie Liu et al.
Yating Chen et al.
Obesity is an established risk factor for atrial fibrillation (AF) and is associated with hypersecretion of the adipokine chemerin. Chemerin has been linked to the AF initiation and progression predominantly through Chemokine-like receptor ...
One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels [0.03%]
一个激活所有通道的方法吗？：对K2P通道调节剂结合位点的探索研究
Edward Mendez-Otalvaro,Wojciech Kopec,Marcus Schewe et al.
Edward Mendez-Otalvaro et al.
The modulator pocket is a cryptic site discovered in the TREK1 (K2P2.1) K2P channel. This pocket, located close to the selectivity filter, accommodates agonists that enhance the channel's activity. Since its discovery, equivalent sites in o...
Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment [0.03%]
KCC2的调节性降解，它是神经元发育和突触传递所必需的钾氯共转运体
Morgan Kok,Elias Aizenman,Christopher J Guerriero et al.
Morgan Kok et al.
Neuronal function requires fine-tuned and coordinated activity of several ion channels and transporters. One member of this ensemble is the KCC2 potassium-chloride cotransporter. Because KCC2 expression is required for GABA-dependent inhibi...
Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo [0.03%]
TRPV1依赖性的CACNA1B基因失活揭示了CaV2.2通道在体内的细胞特异性功能
Remy Y Meir,Martin S Sisti,Arturo Andrade et al.
Remy Y Meir et al.
Voltage-gated CaV2.2 channels underlie the N-type current, and they regulate calcium entry at many presynaptic nerve endings to control transmitter release. A role for CaV2.2 channels has been well established in the transmission of sensory...
Gating modulation and potentiation of amiodarone blockage of the Kv10.1 potassium channel bu KB130015, an amiodarone derived molecule [0.03%]
达螺酮衍生分子KB130015调节和加强胺碘酮对Kv10.1钾通道阻滞的作用
Froylán Gómez-Lagunas,Carolina Barriga-Montoya
Froylán Gómez-Lagunas
Kv10.1 is a voltage-gated K+ channel whose structure-function relationships remain incompletely understood, and whose ectopic expression is linked to tumorigenesis. We have recently shown that the antiarrhythmic drug amiodarone inhibits bot...
Orai storeoperated Ca2+ entry channels modulate urethral smooth muscle contractility [0.03%]
Orai介导的Ca2+内流通道调节尿道平滑肌收缩功能
Bernard T Drumm,Neha Gupta
Bernard T Drumm
In the European Union, urinary incontinence (UI) affects 45% of adults during their lifetime, representing a major clinical and socio-economic burden. Failure of urethral smooth muscle (USM) to contract normally (hypo or hypercontractility)...
SCN3A-related neurodevelopmental disorder: Clinical case reports and biophysical characterization [0.03%]
与SCN3A相关的神经发育障碍：临床病例报告及生物物理特征分析
Mohammad-Reza Ghovanloo,Cynthia Gershome,Robin van der Lee et al.
Mohammad-Reza Ghovanloo et al.
SCN3A, the gene encoding the voltage-gated sodium channel, Nav1.3, plays a critical role in early neuronal development. Although traditionally considered a neonatal channel, emerging evidence has linked SCN3A mutations to a spectrum of neur...