Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases [0.03%]
STIM和Orai蛋白介导的内质网钙释放激活钙通道在心血管疾病中的作用及机制研究进展
Xin Liao,Chenglin Pan,Xueqing Guo et al.
Xin Liao et al.
Store-operated calcium entry (SOCE) mediated by STIM and Orai proteins is a fundamental Ca2+ influx mechanism that critically regulates intracellular calcium homeostasis and participates in cardiovascular pathophysiology. Upon endoplasmic r...
Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders [0.03%]
NADPH氧化酶2衍生的活性氧在心脏电生理障碍中的作用
Bin Li,Ying Dong,Yating Chen et al.
Bin Li et al.
Oxidative stress mediated by NADPH oxidase 2 (NOX2), a major source of reactive oxygen species in the myocardium, is an important mechanism that underlies cardiac arrhythmias. NOX2 is activated by the precise assembly of multiple protein su...
mTORC2-Nav1.2 signaling drives early hyperexcitability in Alzheimer's disease mouse model [0.03%]
mTORC2-Nav1.2信号轴在阿尔茨海默病小鼠模型早期过度兴奋中的作用
Nolan M Dvorak,Jeffrey L Noebels
Nolan M Dvorak
Hyperexcitability is a biomarker of early-stage Alzheimer's Disease (AD) and hastens cognitive decline later in its course. Mechanistic target of rapamycin (mTOR) signaling contributes to the slope of this trajectory, as evidenced by early ...
Role for TREK-1 as a polymodal sensor and regulator of cell activity [0.03%]
TREK-1作为多模式传感器和细胞活性调节器的作用
Alexander J Winkle,Aparna Odayil Muralidharan,Christian Renee McClenney et al.
Alexander J Winkle et al.
TREK-1 (KCNK2) is a polymodal two-pore domain potassium (K2P) channel that functions as a background K+ conductance and integrator of mechanical, chemical, and thermal stimuli across diverse cell types. Its unique structure enables sensitiv...
Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants [0.03%]
hERG电压感应域变异的杂合表达诱导贩运缺陷的定量分析
Yihong Zhang,Joseph Carr,Jules C Hancox et al.
Yihong Zhang et al.
Long QT Syndrome Type 2 (LQT2) is a cardiac disorder caused by Loss of Function (LOF) mutations in the KCNH2 gene that encodes the K+ channel hERG (Kv11.1). Mistrafficking of hERG LOF variants is the dominant cause of LQT2. We recently char...
Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [0.03%]
糖尿病及其并发症中的瞬时受体电位香草素样通道(TRPV)和 Canonical通道(TRPC)的功能及机制研究
Yi Wu,Shengming Chen,Xiaolu Xia
Yi Wu
TRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion. Moreover, TRPC channels h...
Transient receptor potential channels in Flaviviridae infection: A comprehensive review [0.03%]
黄病毒科感染中的瞬时受体电位通道：全面综述
Fuchun Jiang,Xiaoqiang Yao,Chang-Bo Zheng
Fuchun Jiang
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including...
TRPV4 mediates macrophage polarization involved in inflammatory root resorption induced by mechanical pressure [0.03%]
TRPV4介导的巨噬细胞极化参与机械压应力诱导的根吸收炎症反应
Xuanchen Su,Min Jin,Yue Chen et al.
Xuanchen Su et al.
In clinical orthodontic treatment, mechanical pressure applied to the tooth root triggers orthodontically induced inflammatory root resorption (OIIRR). An elevated M1/M2 macrophage polarization ratio is a key factor in OIIRR on the pressure...
Bladder under stress: Pathological and adaptive shifts in channel expression [0.03%]
膀胱承压：通道表达的病理和适应性变化
Karl Swärd,Karl-Erik Andersson,Bengt Uvelius
Karl Swärd
Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcrip...
Role of TRPV4 channels in high glucose-induced neurotoxicity in a neuronal-like cell model [0.03%]
TRPV4通道在高糖诱导的神经毒性中的作用——一种神经元样细胞模型研究
Andrés Mauricio García-Cuevas,Laura Victoria Muñoz-Rincón,Julio César Sánchez-Naranjo
Andrés Mauricio García-Cuevas
Neurological dysfunction caused by hyperglycemia has been linked to abnormal activity of the transient receptor potential vanilloid (TRPV) channel family, especially in diabetic neuropathy. TRPV4 functions as a sensor of oxidative stress re...