Role for TREK-1 as a polymodal sensor and regulator of cell activity [0.03%]
TREK-1作为多模式传感器和细胞活性调节器的作用
Alexander J Winkle,Aparna Odayil Muralidharan,Christian Renee McClenney et al.
Alexander J Winkle et al.
TREK-1 (KCNK2) is a polymodal two-pore domain potassium (K2P) channel that functions as a background K+ conductance and integrator of mechanical, chemical, and thermal stimuli across diverse cell types. Its unique structure enables sensitiv...
Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants [0.03%]
hERG电压感应域变异的杂合表达诱导贩运缺陷的定量分析
Yihong Zhang,Joseph Carr,Jules C Hancox et al.
Yihong Zhang et al.
Long QT Syndrome Type 2 (LQT2) is a cardiac disorder caused by Loss of Function (LOF) mutations in the KCNH2 gene that encodes the K+ channel hERG (Kv11.1). Mistrafficking of hERG LOF variants is the dominant cause of LQT2. We recently char...
Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [0.03%]
糖尿病及其并发症中的瞬时受体电位香草素样通道(TRPV)和 Canonical通道(TRPC)的功能及机制研究
Yi Wu,Shengming Chen,Xiaolu Xia
Yi Wu
TRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion. Moreover, TRPC channels h...
Transient receptor potential channels in Flaviviridae infection: A comprehensive review [0.03%]
黄病毒科感染中的瞬时受体电位通道：全面综述
Fuchun Jiang,Xiaoqiang Yao,Chang-Bo Zheng
Fuchun Jiang
Diseases caused by Flaviviridae viruses exert profound global health and economic burdens due to their high incidence and associated mortality. Infection by the Flaviviridae family often leads to severe acute or chronic illnesses, including...
TRPV4 mediates macrophage polarization involved in inflammatory root resorption induced by mechanical pressure [0.03%]
TRPV4介导的巨噬细胞极化参与机械压应力诱导的根吸收炎症反应
Xuanchen Su,Min Jin,Yue Chen et al.
Xuanchen Su et al.
In clinical orthodontic treatment, mechanical pressure applied to the tooth root triggers orthodontically induced inflammatory root resorption (OIIRR). An elevated M1/M2 macrophage polarization ratio is a key factor in OIIRR on the pressure...
Bladder under stress: Pathological and adaptive shifts in channel expression [0.03%]
膀胱承压：通道表达的病理和适应性变化
Karl Swärd,Karl-Erik Andersson,Bengt Uvelius
Karl Swärd
Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcrip...
Role of TRPV4 channels in high glucose-induced neurotoxicity in a neuronal-like cell model [0.03%]
TRPV4通道在高糖诱导的神经毒性中的作用——一种神经元样细胞模型研究
Andrés Mauricio García-Cuevas,Laura Victoria Muñoz-Rincón,Julio César Sánchez-Naranjo
Andrés Mauricio García-Cuevas
Neurological dysfunction caused by hyperglycemia has been linked to abnormal activity of the transient receptor potential vanilloid (TRPV) channel family, especially in diabetic neuropathy. TRPV4 functions as a sensor of oxidative stress re...
Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ channel, as verified by single-channel currents [0.03%]
通过单通道电流验证钾离子通道的选择性过滤器中K＋和Tl＋的离子占据相似性
Lena Diederich,Jessica Múnera-Jaramillo,Ulf-Peter Hansen et al.
Lena Diederich et al.
Voltage-dependent gating in the selectivity filter of potassium channels is modulated by the permeating ions binding within the filter. In the viral Kcv channel, filter gating occurs on the sub-millisecond time scale. Crystallographic data ...
Tal Brandwine-Shemmer,Nicolas A Barbera,Irena Levitan et al.
Tal Brandwine-Shemmer et al.
TRPV1 is a polymodal ion channel activated by vanilloids, noxious heat, and pro-inflammatory signals. A recent cryo-EM structure of human TRPV1 bound to SAF312, a potent, selective, noncompetitive antagonist, revealed a cholesterol molecule...
Hadil Najjar,Veronika Aichner,Magdalena Prantl et al.
Hadil Najjar et al.
Orai channels form highly Ca2+-selective pores in the plasma membrane (PM) and represent one of the two essential components of the Ca2+ release-activated Ca2+ (CRAC) channel. The second component is the Stromal Interaction Molecule (STIM) ...