Elevated E2F6 Expression in Colorectal Cancer Tissues and Its Association With Clinicopathological Features [0.03%]
结直肠癌组织中E2F6高表达及其临床病理特征分析
Da Tong Zeng,Ke Jun Wu,Jian Di Li et al.
Da Tong Zeng et al.
Background: Colorectal cancer (CRC) is the third most common malignancy worldwide, and the role of E2F transcription factor 6 (E2F6) in CRC remains controversial. ...
Incidence and Prognostic Value of TP53, STK11, and KEAP1 Mutations Between De Novo Versus Recurrent Actionable Mutation-Negative Non-Small Cell Lung Cancer: A Single-Center Retrospective Study [0.03%]
新发与复发驱动基因阴性的非小细胞肺癌中TP53、STK11和KEAP1突变的发生率及预后价值：单中心回顾性研究
Jorge Raul Vazquez-Urrutia,Natasha Venugopal,Junjia Zhu et al.
Jorge Raul Vazquez-Urrutia et al.
Background: In non-small cell lung cancer (NSCLC), mutations in TP53, STK11, and KEAP1 are common in tumors lacking actionable oncogenic drivers and have been associated with poor outcomes, though their prognostic impact ...
Could Pretreatment Computed Tomography Imaging Accurately Predict the Pathological Diagnosis of Lymph Node Involvement in Thymic Epithelial Tumors? [0.03%]
术前CT影像能否准确预测胸腺上皮肿瘤患者的淋巴结病理分期？
Hao-Yun Liu,Mei-Ci Chen,Jo-Yu Chen et al.
Hao-Yun Liu et al.
Background: Thymic epithelial tumors (TETs) are the most common primary malignancies of the anterior mediastinum. Initial treatment planning for TETs is based on staging determined through computed tomography (CT) imaging...
Pan-Cancer Analysis of NOP2 Reveals Its Prognostic Relevance and Association With the Tumor Immune Microenvironment [0.03%]
泛癌分析揭示NOP2的预后相关性及其与肿瘤免疫微环境的关系
Chuan Kun Yang,Wei Li,Shuang Liu et al.
Chuan Kun Yang et al.
Background: RNA 5-methylcytosine (m5C) modification has emerged as an important layer of epigenetic regulation in cancer biology. NOP2 (also known as NSUN1), a nucleolar RNA methyltransferase involved in ribosomal RNA met...
De-Escalation of Axillary Surgery: A Review of Choosing Wisely Guideline Evidence [0.03%]
锁骨下手术的减量化：一篇关于选择明智指南证据的综述论文
Abigail Grapes,Jessica Young,Kazuaki Takabe
Abigail Grapes
Management of the axilla in early stage breast cancer has shifted toward less invasive approaches as evidence demonstrates equivalent oncologic outcomes with reduced morbidity. In older women with biologically favorable disease, the value o...
TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer [0.03%]
TP53丢失通过激活mTORC1和抑制自噬驱动免疫原性冷的结直肠癌发生发展
Eunseuk Lee,Dana Al-Assi,Randy Rivera-Rueda et al.
Eunseuk Lee et al.
Background: Microsatellite-stable colorectal cancer (MSS CRC) is typically resistant to immune checkpoint blockade and remains an "immune-cold" disease. Wild-type p53 is known to restrain mTOR signaling and support autoph...
Identification of Genes and Construction of Prognostic Model of Lung Adenocarcinoma Based on Propionate Metabolism-Related Genes [0.03%]
基于丙酸代谢相关基因的肺癌腺癌预后模型的构建及关键基因鉴定
Min Min Li,Wei Jia Fu,Ying Zhou et al.
Min Min Li et al.
Background: Dysregulation of propionate metabolism can enhance the invasive properties of lung adenocarcinoma (LUAD) cells and increase their metastatic potential. Therefore, we constructed a predictive model based on pro...
Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells [0.03%]
多组学和单细胞孟德尔随机化揭示VNN2在静息自然杀伤细胞中肺腺癌中的潜在作用
Zhi Chun Xue,Jing Lin,Jian Hui Wu et al.
Zhi Chun Xue et al.
Background: We aimed to evaluate the potential association between genetically predicted vanin-2 (VNN2) expression and lung adenocarcinoma (LUAD) risk, and to explore the immune cell subtype that may underlie this relatio...
Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer [0.03%]
双向孟德尔随机化分析揭示自身免疫疾病与结直肠癌间的因果关系
Shuang Liu,Kun Chen,Yue Qi Wang et al.
Shuang Liu et al.
Background: Observational studies have reported associations between autoimmune diseases (AIDs) and colorectal cancer (CRC), but whether these relationships are causal remains unclear. ...
Strong Signals of Adverse Events in Tyrosine Kinase Inhibitor Therapy for Liver Cancer Treatment [0.03%]
肝癌酪氨酸激酶抑制剂治疗的不良事件强信号分析研究
Wen Xuan Zhou,Jun Hao Fan,Qian Wen Ni et al.
Wen Xuan Zhou et al.
Background: This study was to identify strong adverse event (AE) signals associated with four tyrosine kinase inhibitors (TKIs) (sorafenib, regorafenib, lenvatinib, and cabozantinib), and compare these signals with regula...