Real-World Data on the Use of Cyclin-Dependent Kinase 4/6 Inhibitors in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced/Metastatic Breast Cancer [0.03%]
激素受体阳性/人表皮生长因子受体2阴性晚期/转移性乳腺癌中细胞周期蛋白依赖性激酶4/6抑制剂实际应用的数据分析
Αntria Savvidou,Anastasia Constantinidou,Lefteris Zacharia et al.
Αntria Savvidou et al.
Background: Cyclin-dependent kinase (CDK)4/6 inhibitors (CDK4/6i) have been shown to improve the outcome of patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) advanced/...
TRIM33 Reverses Cisplatin Resistance in Non-Small Cell Lung Cancer by Regulating the PI3K/AKT Pathway via Ubiquitination-Mediated Degradation of LPCAT1 [0.03%]
TRIM33通过泛素介导的LPCAT1降解调节PI3K/AKT途径逆转非小细胞肺癌顺铂耐药性
Jie Huang,Bao Qing Wang,Qin Wu et al.
Jie Huang et al.
Background: Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for 80-85% of cases. Cisplatin (DDP) is a first-line chemotherapy drug for NSCLC, but acq...
Omission of Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: Expanding Evidence in Clinically Node-Negative and Neoadjuvant Therapy Responders [0.03%]
早期乳腺癌省略哨兵淋巴结活检的临床证据：无临床淋巴结转移和新辅助治疗有反应患者的证据
Abigail Grapes,Jessica Young,Kazuaki Takabe
Abigail Grapes
Management of the axilla in early-stage breast cancer has progressively evolved toward less invasive approaches, as advances in tumor biology, imaging, and local and systemic therapies have improved outcomes while highlighting the morbidity...
Detection of Longer Leukocyte Telomere Length in Patients With Bone Sarcomas [0.03%]
骨肉瘤患者较长的淋巴细胞端粒长度检测
Mariana Chantre-Justino,Rafaele Tavares Silvestre,Lucas Delmonico et al.
Mariana Chantre-Justino et al.
Background: Bone sarcomas are rare and heterogeneous malignant neoplasms of mesenchymal origin, often associated with poor clinical outcomes. Being rare neoplasms, a comprehensive analysis of the molecular mechanisms invo...
Exploring Two Decades of Cancer Trends in Adolescents and Young Adults: Insights From a Resource-Restricted Country [0.03%]
探索资源受限国家青少年和青壮年群体二十年癌症流行趋势及其启示
Maha Barbar,Asem Mansour,Rawad Rihani et al.
Maha Barbar et al.
Background: Over 40% of Jordan's population falls within the adolescent and young adult (AYA) age group (15-39 years). Cancer diagnosed in this population has unique biological, clinical, and psychosocial characteristics....
Association of Arylacetamide Deacetylase-Mediated Extracellular Matrix Remodeling With Immune Exclusion in Pancreatic Cancer [0.03%]
胰腺癌中由芳基乙酰胺脱乙酰酶介导的细胞外基质重塑与免疫排除的关系
Chao Wu,Jun Yang
Chao Wu
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis, characterized by a desmoplastic tumor microenvironment (TME) that limits immune cell infiltration and diminishes respo...
Immunohistochemistry as a Cornerstone in Lung Cancer Diagnosis: Subtyping Based on the 2021 World Health Organization Classification and Its Practical Application [0.03%]
免疫组化在肺癌诊断中的基石作用：基于2021年世界卫生组织分类的分型及其实际应用
Imrana Tanvir,Amber Hassan,Bushra Nisar et al.
Imrana Tanvir et al.
Background: Lung cancer is the leading cause of cancer-related deaths worldwide, and precise histological classification is vital for therapy decisions. Given diagnostic limitations with small biopsies, immunohistochemist...
Elevated E2F6 Expression in Colorectal Cancer Tissues and Its Association With Clinicopathological Features [0.03%]
结直肠癌组织中E2F6高表达及其临床病理特征分析
Da Tong Zeng,Ke Jun Wu,Jian Di Li et al.
Da Tong Zeng et al.
Background: Colorectal cancer (CRC) is the third most common malignancy worldwide, and the role of E2F transcription factor 6 (E2F6) in CRC remains controversial. ...
Incidence and Prognostic Value of TP53, STK11, and KEAP1 Mutations Between De Novo Versus Recurrent Actionable Mutation-Negative Non-Small Cell Lung Cancer: A Single-Center Retrospective Study [0.03%]
新发与复发驱动基因阴性的非小细胞肺癌中TP53、STK11和KEAP1突变的发生率及预后价值：单中心回顾性研究
Jorge Raul Vazquez-Urrutia,Natasha Venugopal,Junjia Zhu et al.
Jorge Raul Vazquez-Urrutia et al.
Background: In non-small cell lung cancer (NSCLC), mutations in TP53, STK11, and KEAP1 are common in tumors lacking actionable oncogenic drivers and have been associated with poor outcomes, though their prognostic impact ...
Could Pretreatment Computed Tomography Imaging Accurately Predict the Pathological Diagnosis of Lymph Node Involvement in Thymic Epithelial Tumors? [0.03%]
术前CT影像能否准确预测胸腺上皮肿瘤患者的淋巴结病理分期？
Hao-Yun Liu,Mei-Ci Chen,Jo-Yu Chen et al.
Hao-Yun Liu et al.
Background: Thymic epithelial tumors (TETs) are the most common primary malignancies of the anterior mediastinum. Initial treatment planning for TETs is based on staging determined through computed tomography (CT) imaging...