TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer
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Background: Microsatellite-stable colorectal cancer (MSS CRC) is typically resistant to immune checkpoint blockade and remains an "immune-cold" disease. Wild-type p53 is known to restrain mTOR signaling and support autophagy, y... ...
