Extracts of Periplaneta americana alleviate hepatic fibrosis by affecting hepatic TGF-β and NF-κB expression in rats with pig serum-induced liver fibrosis [0.03%]
美洲小蠊重楼提取物通过影响TGF-β和NF-κB的表达抑制胎猪血清诱导的大鼠肝纤维化
Dingchun Li,Dehong Ma,Ye Liu et al.
Dingchun Li et al.
Introduction: Liver fibrosis is caused by continuous wound healing responses to various harmful stimuli, including viral infection, drugs, alcohol, and autoimmune liver disease. The purpose of this study was to examine th...
Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity [0.03%]
七氟烷致新生大鼠重复暴露引起幼年期认知功能障碍：miR-497在七氟烷所致神经毒性中的作用
Yuanyuan Que,Fangxiang Zhang,Jing Peng et al.
Yuanyuan Que et al.
Introduction: Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity....
Psoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells [0.03%]
补骨脂内酯通过内质网应激抑制人成骨肉瘤细胞增殖并促进其凋亡
Shubo Li,Hongqin Tu
Shubo Li
Introduction: Psoralen is a main active component of Psoralea corylifolia Linn. (Leguminosae). Psoralen has been reported to show antitumor effects and activity to accelerate osteoblastic proliferation. Nevertheless, the ...
Candidate genes responsible for lipid droplets formation during adipogenesis simultaneously affect osteoblastogenesis [0.03%]
调控脂滴生成的候选基因同时影响骨形成祖细胞的分化成熟
Xia Yi,Ping Wu,Ying Gong et al.
Xia Yi et al.
Introduction: With cellular lipid storage varying, the balance between lipid intake and lipid degradation was a must to keep healthy and determined the level of lipid droplets. Although lipid droplets accumulation had bee...
Distribution of dopamine-immunoreactive neurons in the brain of the male native Thai chicken [0.03%]
泰国本地公鸡大脑多巴胺免疫反应性神经元的分布特征研究
Boonyarit Kamkrathok,Yupaporn Chaiseha
Boonyarit Kamkrathok
Introduction: Dopamine (DA) is a neurotransmitter/neuromodulator found in both central and peripheral nervous systems. It plays several physiological functions in some mammalian and avian species. DA has been indicated to...
Plasmid-based CRISPR-Cas9 system efficacy for introducing targeted mutations in CD81 gene of MDA-MB-231 cell line [0.03%]
基于质粒的CRISPR-Cas9系统在MDA-MB-231细胞系CD81基因中引入靶向突变的有效性评估
Kasra Arbabi Zaboli,Hossein Rahimi,Jose Thekkiniath et al.
Kasra Arbabi Zaboli et al.
Introduction: Breast cancer has been represented a challenging issue worldwide as it is one of the major leading causes of death among women. CD81 gene, a member of the tetraspanin protein family, has been associated with...
Insulin-like growth factor-1 inhibits apoptosis of rat gastric smooth muscle cells under high glucose condition via adenosine monophosphate-activated protein kinase (AMPK) pathway [0.03%]
胰岛素样生长因子-1通过腺苷单磷酸活化蛋白激酶信号通路抑制高糖环境下大鼠胃壁肌层细胞的凋亡
Xiang-Zi Zhang,Yan Sun,Mo-Han Zhang et al.
Xiang-Zi Zhang et al.
Introduction: Diabetic gastroparesis (DGP) is a common chronic complication of diabetes characterized by decreased gastric motility, and an effective number of gastric smooth muscle cells (GSMCs) ensures gastric motility....
Wnt/PCP pathway regulates the migration and neural differentiation of mesenchymal stem cells in vitro [0.03%]
Wnt/PCP信号通路调控骨髓间充质干细胞的体外迁移和神经分化
Panpan Yao,Qin Yu,Lujie Zhu et al.
Panpan Yao et al.
Introduction: Mesenchymal stem cells (MSCs) are an excellent donor graft source due to their potential for self-renewal and multidirectional differentiation. However, the potential mechanisms involved in MSC homing and ne...
5-fluorouracil suppresses stem cell-like properties by inhibiting p38 in pancreatic cancer cell line PANC-1 [0.03%]
5-氟尿嘧啶通过抑制P38降低胰腺癌细胞系PANC-1的干性特质
Jin Zhao,Xueying Shi,Changcheng Dong et al.
Jin Zhao et al.
Introduction: Suppressing the phenotype of cancer stem cells (CSCs) is a promising treatment strategy for cancer. P38 mitogen-activated protein kinases (MAPK, p38) play an important role in the occurrence, development, an...
EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells [0.03%]
EID1通过促进滋养细胞的增殖和侵袭在早发型子痫前期中发挥保护作用
Ying Li,Jiuxiang Feng,Yue Bian et al.
Ying Li et al.
Introduction: Pre-eclampsia is a pregnancy-specific syndrome, which is partly due to abnormal proliferation and invasion of trophoblast cells. EP300 interacting inhibitor of differentiation 1 (EID1) participates in cell p...