Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) primes adrenal cortex metabolism without directly driving steroidogenesis [0.03%]
线粒体12S rRNA型开放阅读框(MOTS-c)调节肾上腺皮质代谢但不直接驱动类固醇生成
Małgorzata Blatkiewicz,Kacper Kaminski,Marta Sobalska-Kwapis et al.
Małgorzata Blatkiewicz et al.
Introduction: Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c), a 16-amino acid mitochondrial-derived peptide, regulates cellular metabolism through AMPK and mTOR signaling and exerts protective effects ac...
Expression of BDNF-TrkB-AKT1 pathway components and apoptosis-related factors across yak brain regions at low and high altitudes [0.03%]
高海拔和低海拔地区藏绵羊脑组织BDNF-TrkB-AKT1通路及凋亡相关因子表达量研究
Qian Zhang,Yan Cui,Junfeng He et al.
Qian Zhang et al.
Introduction: This study investigated the expression of brain-derived neurotrophic factor (BDNF) signaling components (BDNF-TrkB-AKT1) and apoptosis-related factors (Bcl-2 and Bax) in yak brain regions at different altitu...
Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance [0.03%]
外泌体长链非编码RNA Lnc-DKL1-35通过非经典细胞因子谱系将小胶质细胞重编为促肿瘤表型以促进胶质母细胞瘤进展和化学抗性
Dan Li,Yufeng Li,Zhuo Wang et al.
Dan Li et al.
Introduction: Temozolomide (TMZ) resistance in glioblastoma (GBM) involves dynamic crosstalk of cancer cells with tumor-associated microglia, but the role of exosomal long non-coding RNAs (lncRNAs) remains poorly defined....
Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects [0.03%]
潜在转化生长因子β结合蛋白1(LTBP1)：作为多功能细胞外基质调节因子在人类疾病中的作用。从分子机制到临床应用前景
Yi Liu,Minming Yi,Huan Wei et al.
Yi Liu et al.
Latent transforming growth factor-beta-binding protein 1 (LTBP1) is a key regulator of the extracellular matrix (ECM). However, its role as a molecular hub that integrates biochemical signals within the mechanical microenvironment across di...
A recombinase polymerase amplification-coupled Cas12a for detection of Salmonella Typhi - a preliminary report [0.03%]
基于重组酶聚合酶扩增的Cas12a检测沙门氏菌的一项初步研究
Qian Dong,Chujun Luo
Qian Dong
Introduction: . Typhoid fever, a disease resulting from an infection with Salmonella Typhi (S. Typhi) remains widespread in economically disadvantaged regions, where it continues to be a critical public health concern. As...
Molecular landscape of the mouse adrenal gland and adjacent adipose tissue by spatial transcriptomics [0.03%]
空间转录组学绘制小鼠肾上腺和邻近脂肪组织的分子图谱
Malgorzata Blatkiewicz,Szymon Hryhorowicz,Marta Szyszka et al.
Malgorzata Blatkiewicz et al.
Introduction: . The adrenal glands are central regulators of endocrine homeostasis and stress adaptation. Despite decades of research, the molecular mechanisms governing adrenal zonation and cortical renewal remain incomp...
Critical assessment of microscopy methods for detecting single- and double-strand DNA breaks [0.03%]
显微技术鉴定单链和双链DNA损伤的批判性评估
Agnieszka Hoang-Bujnowicz,Julita Wesolowska,Agnieszka Ostromecka et al.
Agnieszka Hoang-Bujnowicz et al.
A laboratory toolbox for detecting and quantifying DNA breaks in animal cells and tissues includes various methods that employ biochemical tests, DNA sequencing, or imaging approaches. Various methods based on microscopy were developed to d...
VE1 immunohistochemistry as a screening tool for BRAFV600E mutation in lung adenocarcinoma: evidence from a Montenegro National Cohort [0.03%]
BRAFV600E突变的筛选标志物VE1免疫组织化学在肺癌腺癌中的应用——一项来自黑山共和国的全国队列研究证据
Branko Campar,Mirjana Miladinovic,Janja Raonic et al.
Branko Campar et al.
Introduction: Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) representing the majority of cases. Molecular profiling of NSCLC has identified multiple g...
Immunohistochemical and histopathological characteristics of adenomas and adenocarcinomas of Meibomian glands in dogs [0.03%]
犬眼睑腺腺瘤和腺癌的免疫组织化学和组织病理学特征
Rafal Ciaputa,Adam Szymerowski,Kacper Zebrowski et al.
Rafal Ciaputa et al.
Introduction: This study aimed to provide a comprehensive histopathological and immunohistochemical analysis of Meibomian adenomas and adenocarcinomas. Ma...
Tectochrysin alleviates high-glucose-induced retinal pigment epithelial cell injury through Nrf2/HO-1 activation [0.03%]
黄酮类化合物TECT通过激活Nrf2/HO-1信号减轻高糖诱导的视网膜色素上皮细胞损伤
Yuan Sui,Chengsen Zhang,Bingbing Jiang et al.
Yuan Sui et al.
Introduction: Diabetic retinopathy involves retinal pigment epithelium (RPE) dysfunction. Tectochrysin is a natural flavonoid and antioxidant. However, its effects on retinal pigment epithelial cells remain unveiled. In t...