Fundamental research on the treatment of periodontitis with Kangfuxin (KFX) extended-release gel [0.03%]
康氟新防治牙周炎的基础研究
Jianzhao Ding,Ye Zhang,Qiyan Li et al.
Jianzhao Ding et al.
Introduction: Periodontitis, a chronic inflammatory disease that severely compromises oral health and is linked to systemic disorders, has attracted increasing research attention. Kangfuxin (KFX), an ethanol extract deriv...
Tectochrysin suppresses the profibrotic phenotype of human keloid fibroblasts and is associated with reduced nuclear p65 accumulation [0.03%]
姜黄素抑制人类瘢痕疙瘩成纤维细胞的促纤维化表型并减少核p65聚集
Lin Ma,Wei Zheng,Weibo Song et al.
Lin Ma et al.
Introduction: Keloids are fibroproliferative scars characterized by persistent fibroblast activation and excessive extracellular matrix deposition. Tectochrysin is a natural flavone with anti-inflammatory and anti-oxidati...
IGFL2-AS1 knockdown enhances erastin-induced ferroptosis-associated changes in oral squamous cell carcinoma [0.03%]
IGFL2-AS1敲低通过促进Erastin诱导的铁死亡相关变化抑制口腔鳞状细胞癌进展
Li Li,Ye Yin
Li Li
Introduction: Long non-coding RNA (lncRNA) IGFL2-AS1 has been implicated in oral squamous cell carcinoma (OSCC) progression, whereas its relationship to ferroptosis remains unclear. Erastin is a small-molecule ferroptosis...
Esculetin ameliorates sevoflurane-induced cognitive dysfunction in aged mice by suppressing neuroinflammation via inhibition of NF-κB/NLRP3 signaling [0.03%]
Esculetin通过抑制NF-κB / NLRP3信号通路减轻七氟烷致年鼠认知障碍
Xiaoli Cai,Zhang Tian,Qingyun Zhang et al.
Xiaoli Cai et al.
Introduction: . The widely used inhalational anesthetic sevoflurane increases susceptibility to postoperative cognitive dysfunction (POCD), especially among the elderly. Esculetin, a natural coumarin compound derived from...
Lactucin inhibits growth and induces apoptosis in gastric cancer cells by targeting MAPK signaling [0.03%]
乳苣菌素通过靶向MAPK信号通路抑制胃癌细胞的生长和诱导凋亡
Dan Wei,Peng-Li Wang,Jing Jiang
Dan Wei
Introduction: Lactucin, a sesquiterpene lactone isolated from chicory (Cichorium intybus L.), demonstrates broad-spectrum anticancer activity across multiple malignancies, yet its mechanistic role in gastric cancer (GC) r...
Inhibition of miR-33b-5p promotes osteoblast differentiation by regulating ABCA1 in cellular and animal models of osteoporosis [0.03%]
miR-33b-5p的抑制通过调节ABCA1促进骨形成老化小鼠及卵巢切除小鼠骨质疏松模型中的作用研究
Erya Miao,Yanli Li,Fan Feng et al.
Erya Miao et al.
Introduction: Osteoporosis is a major health risk for postmenopausal women and is primarily driven by estrogen decline-induced bone loss. As critical post-transcriptional regulators of gene expression, dysregulated microR...
CRISPR-mediated MLH1 disruption suppresses endometrial cancer growth via genomic instability induction and Wnt/β-catenin pathway inhibition [0.03%]
通过基因组不稳定性诱导和Wnt / β-连环蛋白途径抑制介导的CRISPR干扰MLH1可抑制子宫内膜癌生长
Baoling Xing,Xiaoying Zhang,Li Shen et al.
Baoling Xing et al.
Introduction: MutL homolog 1 (MLH1) loss is a defining molecular feature of endometrial cancer (EC) and a principal driver of microsatellite instability (MSI). Ishikawa cells harbor intrinsic MLH1 promoter hypermethylatio...
Ginsenoside Rg3 inhibits Ang II-induced cardiac fibrosis via the GLP-1 receptor signaling pathway [0.03%]
人参皂苷Rg3通过GLP-1受体信号途径抑制血管紧张素II诱导的心脏纤维化
Jie Zhao,Zheng Yan,Chaokun Guan et al.
Jie Zhao et al.
Introduction: Cardiac fibrosis is a major pathological feature of multiple cardiovascular diseases and an important risk factor for heart failure. Ginsenoside Rg3 (Rg3), a natural triterpenoid saponin extracted from Panax...
Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) primes adrenal cortex metabolism without directly driving steroidogenesis [0.03%]
线粒体12S rRNA型开放阅读框(MOTS-c)调节肾上腺皮质代谢但不直接驱动类固醇生成
Małgorzata Blatkiewicz,Kacper Kaminski,Marta Sobalska-Kwapis et al.
Małgorzata Blatkiewicz et al.
Introduction: Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c), a 16-amino acid mitochondrial-derived peptide, regulates cellular metabolism through AMPK and mTOR signaling and exerts protective effects ac...
Expression of BDNF-TrkB-AKT1 pathway components and apoptosis-related factors across yak brain regions at low and high altitudes [0.03%]
高海拔和低海拔地区藏绵羊脑组织BDNF-TrkB-AKT1通路及凋亡相关因子表达量研究
Qian Zhang,Yan Cui,Junfeng He et al.
Qian Zhang et al.
Introduction: This study investigated the expression of brain-derived neurotrophic factor (BDNF) signaling components (BDNF-TrkB-AKT1) and apoptosis-related factors (Bcl-2 and Bax) in yak brain regions at different altitu...