Comparative study of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the diagnosis of benign and malignant lesions of the gallbladder [0.03%]
增强型超声和增强型CT在胆囊病变定性诊断中的对比研究
Liang Fang,Zhiying Qiu,Lingwen Xu et al.
Liang Fang et al.
This study compared the diagnostic value of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) for differentiating benign and malignant gallbladder (GB) lesions. A retrospective analysis was performed on 15...
Zhimu-Huangbo ameliorates AQP4 depolarization in diabetic cognitive impairment rats by targeting the serum-derived exosomal TIMP3-mediated MMP9/β-DG pathway [0.03%]
知母黄柏通过靶向血清来源TIMP3介导的MMP9/β-DG通路调节AQP4去极化改善糖尿病认知障碍_rat模型中的作用及机制研究
Ying Li,Xueling Lin,Jie Bu et al.
Ying Li et al.
Aquaporin-4 (AQP4) depolarization-mediated glymphatic system (GS) dysfunction is a critical pathological mechanism in diabetic cognitive impairment (DCI). However, its underlying mechanism has not been clarified. The Zhimu-Huangbo (ZMHB) he...
Verification of the protective effect of transfecting brain-derived neurotrophic factor and B-cell lymphoma 2 genes on retina ganglion cells in a rat model of optic nerve injury [0.03%]
视网膜胶质细胞转染脑源性神经营养因子和B淋巴细胞瘤-2基因保护作用的验证研究
Zijia Zhao,Yuan Fang,Gezhi Xu et al.
Zijia Zhao et al.
This pilot study investigated the protective effect of transfecting brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (bcl-2) genes in retinal ganglion cells (RGCs) using in vivo electroporation in an adult rat optic nerve tran...
Clinical significance of imeglimin in older patients with type 2 diabetes: Analysis of a national database and a long-term case suggesting the potential for sarcopenia prevention [0.03%]
イメグリミンの高齢2型糖尿病患者における臨床的意義：国際データベースからの分析と長期症例から見たサルコペニア抑制への可能性
Atsushi Ishimura,Kaori Hashimoto,Hirofumi Ogino
Atsushi Ishimura
We aimed to evaluate the clinical significance of imeglimin in older patients with type 2 diabetes. Prescription trends were analyzed using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (2021-2023). ...
A phase II investigator-initiated, continuation trial of 5-aminolevulinic acid hydrochloride/sodium ferrous citrate (5-ALA-HCl/SFC) for patients with adult-onset Still's disease (AOSD) refractory to glucocorticoids [0.03%]
盐酸氨基叶酸/枸橼酸亚铁治疗糖皮质激素难治性成人Still病患者的II期研究
Remi Sumiyoshi,Tomohiro Koga,Osamu Kamisawa et al.
Remi Sumiyoshi et al.
The aim of this study is to evaluate the efficacy and safety of 5-aminolevulinic acid hydrochloride/sodium ferrous citrate (5-ALA-HCl/SFC) in patients with adult-onset Still's disease (AOSD) refractory to glucocorticoids during the maintena...
Modulatory effects of ingesting dietary fiber and protein before carbohydrates on postprandial interstitial glucose responses [0.03%]
摄入膳食纤维和蛋白质对餐后间质葡萄糖反应的调节作用
Imanaka Yuko Wada,Sanae Tanaka,Chisato Watanabe et al.
Imanaka Yuko Wada et al.
Rapid postprandial elevations in interstitial glucose contribute to the progression of type 2 diabetes and associated vascular complications. Nutritional sequencing strategies, such as consuming dietary fiber or protein before carbohydrate ...
Disproportionality and time-to-onset analyses of drug-induced weight gain using the Japanese Adverse Drug Event Report database [0.03%]
基于日本药品不良事件报告数据库的药物引起体重增加的 disproportionality 和 time-to-onset 分析
Naohito Ide,Rika Shibata,Ken-Ichi Sako et al.
Naohito Ide et al.
Drug-induced weight gain is a clinically important adverse event that can lead to obesity, metabolic syndrome, cardiovascular disease, and reduced treatment adherence. Although several drug classes are known to cause weight gain, the onset ...
Real-world use of non-oral administration of oral anticancer agents via the simple suspension method in Japanese patients with cancer: A nationwide claims-based analysis [0.03%]
日本癌症患者口服抗癌药物非口服给药的现实世界使用情况（基于索赔数据的全国范围内的简单悬浮法分析）
Hiroaki Ohta,Takeo Yasu
Hiroaki Ohta
The enteral administration of drugs as suspensions is a potential alternative route for patients with dysphagia. The simple suspension method is commonly used in Japan; however, nationwide data are lacking. This study aimed to investigate t...
Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval [0.03%]
伊来美肽：首个获批用于巴尔特综合征的卡尼丁定向线粒体治疗药物（附条件批准）
Chenru Zhao,Xuemei Zhuang,Jianjun Gao
Chenru Zhao
Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by tafazzin mutations that impair cardiolipin remodeling, leading to mitochondrial dysfunction and symptoms such as cardiomyopathy, myopathy, and neutropenia. On Septemb...
New diagnostic code "5B72 Undernutrition in Adults" approved for inclusion in the 11th Revision of the International Classification of Diseases (ICD-11) [0.03%]
成人新营养诊断代码“5B72 成人营养不良”已获批准纳入国际疾病分类第十一版(ICD-11)
Machiko Uenishi,Peipei Song
Machiko Uenishi
The World Health Organization (WHO) has approved a new diagnostic code, "5B72 Undernutrition in Adults", in the 11th Revision of the International Classification of Diseases (ICD-11). Prior to this update, undernutrition in adults was repre...