A phase II investigator-initiated, continuation trial of 5-aminolevulinic acid hydrochloride/sodium ferrous citrate (5-ALA-HCl/SFC) for patients with adult-onset Still's disease (AOSD) refractory to glucocorticoids [0.03%]
盐酸氨基叶酸/枸橼酸亚铁治疗糖皮质激素难治性成人Still病患者的II期研究
Remi Sumiyoshi,Tomohiro Koga,Osamu Kamisawa et al.
Remi Sumiyoshi et al.
The aim of this study is to evaluate the efficacy and safety of 5-aminolevulinic acid hydrochloride/sodium ferrous citrate (5-ALA-HCl/SFC) in patients with adult-onset Still's disease (AOSD) refractory to glucocorticoids during the maintena...
Modulatory effects of ingesting dietary fiber and protein before carbohydrates on postprandial interstitial glucose responses [0.03%]
摄入膳食纤维和蛋白质对餐后间质葡萄糖反应的调节作用
Imanaka Yuko Wada,Sanae Tanaka,Chisato Watanabe et al.
Imanaka Yuko Wada et al.
Rapid postprandial elevations in interstitial glucose contribute to the progression of type 2 diabetes and associated vascular complications. Nutritional sequencing strategies, such as consuming dietary fiber or protein before carbohydrate ...
Disproportionality and time-to-onset analyses of drug-induced weight gain using the Japanese Adverse Drug Event Report database [0.03%]
基于日本药品不良事件报告数据库的药物引起体重增加的 disproportionality 和 time-to-onset 分析
Naohito Ide,Rika Shibata,Ken-Ichi Sako et al.
Naohito Ide et al.
Drug-induced weight gain is a clinically important adverse event that can lead to obesity, metabolic syndrome, cardiovascular disease, and reduced treatment adherence. Although several drug classes are known to cause weight gain, the onset ...
Real-world use of non-oral administration of oral anticancer agents via the simple suspension method in Japanese patients with cancer: A nationwide claims-based analysis [0.03%]
日本癌症患者口服抗癌药物非口服给药的现实世界使用情况（基于索赔数据的全国范围内的简单悬浮法分析）
Hiroaki Ohta,Takeo Yasu
Hiroaki Ohta
The enteral administration of drugs as suspensions is a potential alternative route for patients with dysphagia. The simple suspension method is commonly used in Japan; however, nationwide data are lacking. This study aimed to investigate t...
Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval [0.03%]
伊来美肽：首个获批用于巴尔特综合征的卡尼丁定向线粒体治疗药物（附条件批准）
Chenru Zhao,Xuemei Zhuang,Jianjun Gao
Chenru Zhao
Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by tafazzin mutations that impair cardiolipin remodeling, leading to mitochondrial dysfunction and symptoms such as cardiomyopathy, myopathy, and neutropenia. On Septemb...
New diagnostic code "5B72 Undernutrition in Adults" approved for inclusion in the 11th Revision of the International Classification of Diseases (ICD-11) [0.03%]
成人新营养诊断代码“5B72 成人营养不良”已获批准纳入国际疾病分类第十一版(ICD-11)
Machiko Uenishi,Peipei Song
Machiko Uenishi
The World Health Organization (WHO) has approved a new diagnostic code, "5B72 Undernutrition in Adults", in the 11th Revision of the International Classification of Diseases (ICD-11). Prior to this update, undernutrition in adults was repre...
Paltusotine: The first selective nonpeptide agonist of somatostatin receptor 2 (SSTR2) for the treatment of acromegaly [0.03%]
帕鲁妥丁：首个特异性的非肽类生长抑素受体亚型2(SSTR2)激动剂用于治疗肢端肥大症
Yueyi Sun,Daoran Lu,Jianjun Gao
Yueyi Sun
Acromegaly is an endocrine disorder characterized by abnormal enlargement of the extremities and internal organs resulting from excessive secretion of growth hormone (GH) by the pituitary gland, which in turn leads to elevated levels of ins...
Food, medicine, and cosmetic homology: A comprehensive review of bioactive components, functions, and applications of Torreya grandis [0.03%]
TORREYAgrandis食品、医药及化妆品同源性：活性成分、功能和应用的全面综述
Xiaoyan Cui,Chuanyin Shi,Yan Sun
Xiaoyan Cui
Torreya grandis (T. grandis) is one of the evergreen tree species in China. The kernels of T. grandis have been used as traditional medicine and food for thousands of years in China. In recent years, it has also been developed as raw materi...
Development and reliability assessment of a liquid-phase measurement for skin taurine using skin blotting [0.03%]
基于皮肤蘸取技术的皮肤 tau 氨酸液相检测方法建立及其可靠性评估
Katsunori Kato,Kazuhiro Ogai,Yoko Hasegawa et al.
Katsunori Kato et al.
Skin taurine is an indicator of dehydration and can be noninvasively collected through skin blotting. However, conventional taurine measurement using ninhydrin raises safety and specificity concerns, limiting its application in point-of-car...
Purification and characterization of a novel antioxidant protein from Arca subcrenata Lischke [0.03%]
来源于ArksubcrenataLischke的抗氧化蛋白质的分离纯化及性质鉴定
Qing Yan,Hui Shi,Yue Gao et al.
Qing Yan et al.
A novel protein, G1H2GC2, was isolated from Arca subcrenata Lischke using homogenization and ammonium sulfate precipitation, and further purified by several column chromatography techniques including diethyl-aminoethanol (DEAE) Sepharose Fa...