Noa Mizukami,Masayuki Shibuya,Megumi Furukawa et al.
Noa Mizukami et al.
Population aging is increasing worldwide, accompanied by a rising prevalence of cognitive decline and dementia, imposing substantial healthcare and socioeconomic burdens. This study evaluated the effects of lactoferrin on scopolamine-induce...
Are we ready to replace animal models? A perspective on regulatory challenges of human-relevant drug testing systems [0.03%]
准备取代动物模型了吗？关于人类相关药物检测系统的监管挑战透视观点论文
Tanbin Liu,Hongzhou Lu
Tanbin Liu
This perspective examines whether animal models can be gradually replaced by human-relevant New Approach Methodologies (NAMs) in drug development and regulatory evaluation, synthesizing recent advances across hepatology, oncology, neurotoxi...
Associations between wound exudate amino acid profiles and microbial dissimilarity in wound and peri-wound skin in healing wounds [0.03%]
伤口和周围皮肤微生物差异性与伤口渗出物中氨基酸谱型之间的关系研究
Mao Kunimitsu,Makoto Tsunoda,Tomoko Akase et al.
Mao Kunimitsu et al.
Dysbiotic wound microbiota, which is dissimilar to that of the peri-wound skin, delays healing in hard-to-heal wounds. However, rapid and practical methods for detecting wound dysbiosis are lacking and the characteristics of the wound envir...
Exploratory study on the effect of ferulic acid derived from rice bran on dull skin [0.03%]
稻糠来源的香草酸改善暗沉皮肤效果的探索性研究
Jingxiu Zhou,Mizuka Kobayashi,Hanaka Kimura et al.
Jingxiu Zhou et al.
Ferulic acid (FA) from rice bran is known to possess strong antioxidant properties. Furthermore, its multifunctional properties, such as skin whitening, anti-glycation, and anti-inflammatory effects, have attracted attention. We undertook a...
Seasonality of psychiatric symptoms in older adults in long-term psychiatric care [0.03%]
长期精神病护理中老年人的精神病季节性症状
Tomoki Kakehashi,Yuma Sonoda
Tomoki Kakehashi
The annual periodicity of psychiatric symptoms in older adults within long-term care remains under-explored. This exploratory, single-center, retrospective pilot study investigated seasonality in agitation/aggression, depressive symptoms, a...
Docosahexaenoic acid increases tyrosine hydroxylase phosphorylation at Ser40 without increasing tyrosine hydroxylase protein expression in differentiated NG108-15 cells [0.03%]
二十二碳六烯酸增加分化的NG108-15细胞中酪氨酸羟化酶丝氨酸40磷酸化而不增加酪氨酸羟化酶蛋白质表达水平
Daisuke Miyazawa,Natsumi Katsurayama,Hikari Sato et al.
Daisuke Miyazawa et al.
Tyrosine hydroxylase (TH) is the rate‑limiting enzyme in catecholamine biosynthesis, and its activity is regulated by its phosphorylation at specific serine (Ser) residues. In the present study, we investigated the effects of docosahexaeno...
Association of epidural analgesia with childbirth satisfaction among women with severe fear of childbirth: A cross-sectional study [0.03%]
腰麻与严重分娩恐惧女性产后满意度之间的关系：一项横断面研究
Ayako Hayashi,Akari Kanesaki,Nobuhiko Suganuma
Ayako Hayashi
The relationship between fear severity and satisfaction after vaginal delivery was examined with a focus on its association with epidural analgesia. Postpartum cross-sectional questionnaire survey was conducted among 201 healthy women after...
Analytical method validation and feasibility of salivary pregabalin measurement in Japanese volunteers: A pilot study [0.03%]
日本志愿者中分析方法验证及盐酸普瑞巴林漱口水样品测定的可行性——一项初步研究
Hina Itoi,Yoshito Gando,Takeo Yasu et al.
Hina Itoi et al.
This pilot study evaluated whether salivary pregabalin concentrations reflect plasma levels in Japanese volunteers to support non‑invasive therapeutic drug monitoring (TDM). Four healthy adults received a single 75‑mg orally disintegratin...
Metabolic and endocrinological effects of weekly growth hormone replacement therapy with somapacitan in patients with adult growth hormone deficiency after switching from daily growth hormone replacement therapy: A real-world exploratory cohort study [0.03%]
成人生长激素缺乏症患者从每日生长激素替代疗法转换为每周一次的索马匹坦后，其代谢和内分泌效应：一项真实世界探索性队列研究
Ichiro Abe,Keita Kubo,Yuya Fujita et al.
Ichiro Abe et al.
The metabolic and endocrinological effects in patients with adult growth hormone deficiency (AGHD) who switched from daily growth hormone (GH) replacement therapy to weekly GH replacement therapy with somapacitan were evaluated and observed...
Low rate of pharmacists accessing renal function laboratory values: A cross-sectional study using electronic medical records of a Japanese community pharmacy [0.03%]
一项横断面研究：日本社区药房利用电子病历系统查询肾功能指标的药师比例较低
Shingo Kondo,Nozomi Ito,Mari Maese et al.
Shingo Kondo et al.
This study aimed to assess the availability of renal function laboratory values in Japanese community pharmacies and examine their association with the prescription of drugs requiring dosage adjustment. In this cross-sectional observational...