Non-canonical thioesterases in bacterial non-ribosomal peptide biosynthesis [0.03%]
细菌非核糖体肽生物合成中的非常见硫酯酶
Kenichi Matsuda
Kenichi Matsuda
α/β hydrolase fold thioesterases (TEs) play fundamentally important roles in polyketide and non-ribosomal peptide biosynthesis. Type-I TEs, fused at the C-terminus of multi-modular enzymatic assembly lines, dictate the overall molecular s...
Emericellopsic acid, a helvolic acid derivative with a 6/5/7/5 tetracyclic skeleton from sponge-derived Emericellopsis maritima [0.03%]
来自海洋海绵衍生的Emericellopsis maritima中具有六五七五四帖环骨架的helvolic酸衍生物emericellopsic acid
Shasha Li,Xiaomeng Hao,Yan Li et al.
Shasha Li et al.
Emericellopsic acid (1), the first B/C ring-rearranged fusidane-type antibiotic possessing a 6/5/7/5-fused ring framework, together with seven known helvolic acid derivatives, was isolated from the sponge-associated fungus Emericellopsis ma...
Streptomyces secundicynarae sp. nov., a novel actinomycete isolated from the leaves of Cynara scolymus [0.03%]
芽孢链霉菌秋麒麟草亚种nov. sp. Streptomyces secundicynarae 一种从秋麒麟草属植物叶片中分离的新型放线菌
Yu Song,Ting Tang,Ping Mo et al.
Yu Song et al.
A novel actinobacterium strain, designated HUAS ZL42T, was isolated from the leaves of Cynara scolymus. Its taxonomic position was characterized using a polyphasic method. Strain HUAS ZL42T produced spiral spore chains consisting of rod-sha...
New benzoyl sesquiterpenoid, aoganolide, produced by Talaromyces sp. KTF-0021 strain (laeA-introduced mutant of FKI-5759 strain) [0.03%]
由FKI-5759菌株突变体（FKI-5759菌株引入转录因子laeA获得的突变体KTF-0021）产生的具有抗炎活性的新香豆素类化合物奥加农林素及其应用
Karin Hamada,Yoshihiro Watanabe,Yuta Kikuchi et al.
Karin Hamada et al.
To discover novel natural compounds by awakening unexplored or silent BGCs in fungi, our research group has explored the cultured broths of the laeA-introduced mutant fungal strains. In this study, we report the isolation of a new benzoyl s...
Bioinformatics-driven discovery of skin microbiota bacteriocins as potential antibiotics and probiotics [0.03%]
基于生物信息学的皮肤微生物菌素的发现及其作为潜在抗生素和益生菌的研究
Anum Munir,Alan Janbey,Bilawal Sajjad et al.
Anum Munir et al.
The human skin microbiota, comprising a diverse range of microorganisms, including bacteria, viruses, and fungi, plays an important role in maintaining skin health and protecting against pathogenic invasions. Among these microorganisms, cer...
New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482 [0.03%]
一株来源于深海的丝状硫杆菌Serinicoccus marinus KDM482对氨 substituted 苯并咪唑化合物的生物转化及新型α-萘甲酸衍生物的研究
Mai Sakaguchi,Katsuki Kikuchi,Ryota Okamura et al.
Mai Sakaguchi et al.
Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites pro...
In vivo efficacy of atorvastatin in the treatment of Tinea pedis: stepping forward into drug repositioning [0.03%]
阿托伐他汀治疗足癣的体内疗效：药物再定位研究的新进展
Ari Soares de Oliveira Neto,Maria Eliza Samuel Amorim,Rodrigo Luiz Fabri et al.
Ari Soares de Oliveira Neto et al.
The assignment of new therapeutic purposes to drugs, known as drug repositioning, has been an important ally in the search for new antifungal drugs. Statin compounds, which are used systemically as cholesterol-lowering, may also exert direc...
The effect of exogenous glutathione on meropenem susceptibility in Klebsiella pneumoniae-carbapenemases (KPC)-producing bacteria [0.03%]
外源性谷胱甘肽对碳青霉烯类耐药肺炎克雷伯菌(KPC型)亚甲基蓝敏化作用的影响研究
Dong H Kwon,Mital Vasoya,Danya Sankaranarayanan
Dong H Kwon
Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae and Pseudomonas aeruginosa, associated with systemic and hospital-acquired infections, have spread globally and pose a significant public health concern. Glutathione is ...
Halobacin, a herbicidal acyloin derivative from a marine bacterium of the genus Halobacillus [0.03%]
来源于产碱菌属海洋细菌的除草剂卤产碱素(Halobacin)是一种酰醇衍生物
Md Mehebub Al Raji,Desy Wulan Triningsih,Agus Trianto et al.
Md Mehebub Al Raji et al.
Halobacin (1), a new glycosylated acyloin derivative, was isolated from the fermentation broth of a coral-associated bacterium Halobacillus sp. DUNA-S15. The structure of 1 was determined based on NMR and MS analyses and the absolute config...
Streptomyces maremycinicus sp. nov. and its secondary metabolite-biosynthetic gene clusters [0.03%]
链霉菌马雷美西菌素亚种及其次级代谢产物-生物合成基因簇
Hisayuki Komaki,Yasuhiro Igarashi,Tomohiko Tamura
Hisayuki Komaki
Streptomyces strain TP-A0890T, isolated from a soil sample, is a producer of FR-900452 and A-74863a. The taxonomic status was clarified by a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences showed that the strain ...