Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library [0.03%]
从链霉菌培养库中发现选择性更强的抗疟原虫放线菌素衍生物
Aiko Teshima,Awet Alem Teklemichael,Asahi Hirata et al.
Aiko Teshima et al.
Our group explores the antimalarial compounds from the Streptomyces culture library. Pilot screening showed significant antimalarial activity in Streptomyces antibioticus HUT6035 (synonym of strain NBRC3117). We here isolated antimalarial c...
Correction: Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066 [0.03%]
来源于虾蟹鱼子酱内生芽孢杆菌的新羟基脂肪酸 gambaoic acid A–C 和 gambaoic B 甲酯的纠正表征报告
Prima F Hillman,Chaeyoung Lee,Mücahit Varlı et al.
Prima F Hillman et al.
Published Erratum
The Journal of antibiotics. 2026 Apr 17. DOI:10.1038/s41429-026-00922-2 2026
Identification of gymnopilin A10 as an antibacterial agent in Gymnopilus mushrooms and discovery of gymnoprenol B13 from the fruiting bodies of G. orientispectabilis [0.03%]
从 Gymnopilus 菌盖中鉴定出具有抗菌活性的次级代谢产物gymnopilin A10及来自G. orientispectabilis的gymnoprenol B13
Feffiana Muslimin Amin,Rie Netsu,Naoya Oku et al.
Feffiana Muslimin Amin et al.
Gymnopilus orientispectabilis, a bitter and hallucinogenic mushroom found in East Asia, contains polyisoprenepolyol ester gymnopilins as active constituents. Detection of antibacterial activity against a solanaceous plant pathogen, Ralstoni...
(+)-BE-7585A and its derhodinosyl derivative, two cytotoxic 2-thiosugar-containing angucyclines, derived from an actinomycete Amycolatopsis sp. JS6 [0.03%]
来源于链霉菌JS6的两种含2-硫糖的细胞毒类angularuncillines及其derhodinosyl衍生物(+)-BE-7585A
Di Mao,Yuhan Zhang,Lei Zhang et al.
Di Mao et al.
(+)-BE-7585A (1) and its derhodinosyl derivative (2), two rare 2-thiosugar-containing angucyclines, together with their biosynthetic precursor sakyomicin A (3), were isolated from the culture broth of the rare actinomycete Amycolatopsis sp....
Comparative activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. baumannii isolates producing OXA-23 or OXA-23 plus PER-1 enzymes [0.03%]
舒巴坦和舒巴坦/多罗巴坦对产OXA-23或OXA-23+PER-1酶的碳青霉烯耐药鲍曼不动杆菌分离株的作用效果比较
Hasan Cenk Mirza,Aylin Üsküdar Güçlü,Sezin Ünlü et al.
Hasan Cenk Mirza et al.
Our objective was to compare the in vitro activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. baumannii isolates carrying blaOXA-23 or both blaOXA-23 and blaPER-1 genes. We also aimed to investigate the possible ...
Tuspetinib enhances the activity of polymyxin B by inhibiting the GlcNAc6P deacetylase [0.03%]
Tuspetinib通过抑制GlcNAc6P脱乙酰酶增强多粘菌素B的活性
Yu Ouyang,Jinyong Zhang,Ruiqin Cui et al.
Yu Ouyang et al.
The past decade has witnessed the recognition of antibiotic resistance as an emerging threat to public health. Polymyxin B (PMB) is a last-resort antibiotic against multidrug-resistant (MDR) Gram-negative bacteria, but it has nephrotoxicity...
Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066 [0.03%]
来自虾类发酵制品分离的芽孢杆菌SNB-066的新羟基脂肪酸结构变异体 gambaoic acids A-C和gambaoic B 甲酯
Prima F Hillman,Chaeyoung Lee,Mücahit Varlı et al.
Prima F Hillman et al.
Four new hydroxyl fatty acids (HFAs), gambaoic acids A - C (1 - 3) and gambaoic B methyl ester (4), were isolated from Bacillus sp. SNB-066, a bacterium derived from shrimp jeotgal. The chemical structures of these HFAs were elucidated thro...
A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity [0.03%]
一株链霉菌(HKIB0009株)产生的一种新型抗生素金合剂家族化合物的结构及抗菌活性研究
Xingtao Li,Yuxin Sun,Mimi Tian et al.
Xingtao Li et al.
A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (1) and the known aurodox (2) were isolated from the Streptomyces sp. HKIB0009; their structures were determined through comprehensive analysis of NMR and HRMS data. The antiba...
Long-term lung infection suppression in a mouse model caused via the clinical isolate of Burkholderia cenocepacia using the non-traditional antibacterial agent Fluorothiazinone [0.03%]
氟烷基氧酮通过临床分离的伯克霍尔德菌基因不足型菌株在小鼠模型中长期抑制肺部感染
Anna V Soloveva,Stanislava A Nelyubina,Elena Yu Morgunova et al.
Anna V Soloveva et al.
The aim of the study was to evaluate the effects of Fluorothiazinone (FT), the inhibitor of type III secretion system (T3SS), on a model of a long-term infection in animal caused via the clinical isolate of Burkholderia cenocepacia acquired...
Dactylides D and E, two modified 22-membered polyol macrolides isolated from Dactylosporangium aurantiacum [0.03%]
来源于橙色大菌草芽孢菌的两个修饰的22元环多羟基内酯大环(macrolide)化合物D和E
Pankaj Kumar,Yedukondalu Nalli,Sanju Singh et al.
Pankaj Kumar et al.
Two new 22-membered macrolides, dactylide D (1) and dactylide E (2), featuring substituted amino acid or a contiguous dipropionate unit, along with the known dactylosporolide B (3), were purified from Dactylosporangium aurantiacum ATCC 2349...