Biofilm formation and associated biomechanical traits co-segregate with multidrug resistance in typhoidal Salmonella [0.03%]
肠侵袭性沙门氏菌生物被膜的形成及其相关的生物力学特性与多重耐药性共分离
Mehveen Iqbal,Shaista Urooj,Noor Ul Huda et al.
Mehveen Iqbal et al.
Typhoidal Salmonella continues to pose a severe public health threat, with its management increasingly complicated by the rise of antimicrobial resistance. This study investigated 50 clinical isolates of Salmonella Typhi (S. Typhi) and S. P...
Genome mining discovery of aquimarinols, threoninol-containing acylpeptides from Aquimarina muelleri [0.03%]
基因组挖掘发现Aquimarina muelleri产生的含苏氨醇的酰基肽aquimarinols
Zhihan Zhang,Lihan Zhang
Zhihan Zhang
Thioester reductase domain in nonribosomal peptide synthetases catalyzes reductive offloading to produce aldehyde- or alcohol-containing peptides. By genome mining focusing on thioester reductase domains, we isolated aquimarinols A-D, four ...
Expression of a strain-specific non-ribosomal peptide synthetase from Aspergillus lentulus lead to the discovery of a new fungal alkaloid lentoquinazoline [0.03%]
棒曲霉菌株特异性非核糖体肽合成酶的表达导致发现一种新的真菌生物碱lentoquinazoline
Shinji Kishimoto,Yuya Masuyama,Kenji Watanabe
Shinji Kishimoto
Fungi have a potential to produce a variety of natural products for their survival by utilizing dozens of biosynthetic gene clusters (BGCs). Fungal BGCs are typically conserved in species but recent studies showed that many BGCs are maintai...
Aminoacyl-tRNA-dependent enzymes in natural product biosynthesis: structure-function insights [0.03%]
氨酰tRNA依赖性酶在天然产物生物合成中的结构功能见解
Yu Zheng,Yanhui Zhao,Shunji Takahashi
Yu Zheng
Aminoacyl-tRNAs, charged by aminoacyl-tRNA synthetases with cognate amino acids, are essential for protein synthesis in primary metabolism. Beyond this canonical role, increasing evidence highlights their involvement in natural product bios...
Genome mining-based discovery of an atypical fungal non-reducing polyketide synthase encoding dimeric alkylresorcinol biosynthesis [0.03%]
基于基因组挖掘的非典型真菌非还原型聚酮合酶介导的二聚茋类烷基没食子酸生物合成发现
Yuto Homma,Tomoya Hasegawa,Yohei Morishita et al.
Yuto Homma et al.
Genome mining is a powerful strategy for finding biosynthetic gene clusters (BGCs) for unprecedented natural products and their biosynthetic mechanisms. In this study, to obtain novel type polyketides, we performed genome mining focusing on...
1-Hydroxy-1-Norresistoflavins B and C, resistomycin-type polyketides from the Marine-Derived Streptomyces althioticus 2304JJ-041 [0.03%]
来源于海洋链霉菌(S.althioticus)2304jj-041的 Resistomycin类聚酮化合物1-羟基-1-诺 resistoflavin B和C
Hee Jae Shin,Min Ji Kim,Jong Soon Kang et al.
Hee Jae Shin et al.
Two new resistomycin-type pentacyclic polyketide derivatives, designated 1-hydroxy-1-norresistoflavins B (1) and C (2), together with 1R-hydroxy-1-norresistomycin (3) and (6 R)-6,11-Dihydro-7-hydroxy-6-(hydroxymethyl)-8-methoxy-3,9-dimethyl...
Eric J Evans,P Douglas Witt,George G Zhanel et al.
Eric J Evans et al.
A defining characteristic of the Antibiotic Resistance crisis is the lack of substantial investment by the biopharmaceutical industry, which sees limited profit potential in novel antibiotics. We argue for redefining the salient problem for...
Substituted indole derivatives as antifungal agents: design, synthesis, in vitro and in silico evaluations [0.03%]
设计、合成及体内外评估一类新的抗真菌剂吲哚衍生物
Ashish Lamsal,Ashok Maurya,Shankar Thapa et al.
Ashish Lamsal et al.
Indole derivatives possess various biological activities, including antifungal, antibacterial, anticancer, antioxidant, antimalarial, antidiabetic, antitubercular, and anticholinesterase activities. This study focused on the synthesis of in...
High-level polymyxin B resistance and underlying mechanism in a multidrug-resistant Acinetobacter strain isolated from the marine plastisphere [0.03%]
来源于海洋塑料圈的多重耐药不动杆菌菌株的高水平多粘菌素B耐药性及其机制研究
Peng Qin,Wei Ding,Weipeng Zhang
Peng Qin
Antibiotic resistance of Acinetobacter poses a serious threat to public health. Still, the antibiotic resistance features of marine Acinetobacter remain largely unexplored. Here, an Acinetobacter beijerinkii strain, named as MPE71, was isol...