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Tuspetinib enhances the activity of polymyxin B by inhibiting the GlcNAc6P deacetylase

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The past decade has witnessed the recognition of antibiotic resistance as an emerging threat to public health. Polymyxin B (PMB) is a last-resort antibiotic against multidrug-resistant (MDR) Gram-negative bacteria, but it has nephrotoxicity. A cocktail with mo... ...