Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21 [0.03%]
来源于致病有肋球柱霉的新环状二肽半胱胺酰亚麻酸A和B及其生物合成基因簇
Keisuke Kobayashi,Rio Tejima,Kenichiro Nagai et al.
Keisuke Kobayashi et al.
Two new cyclic dipeptides, paranazzamides A (1) and B (2) containing a C7-prenylated tryptophan, were isolated from a culture broth of snake fungal disease-isolate Paranannizziopsis sp. UH-21. This is the first report on the new secondary m...
Synergistic anti-virulence efficacy of citral and carvacrol against mixed vaginitis causing Candida albicans and Gardnerella vaginalis: An in vitro and in vivo study [0.03%]
香茅醛和百里香酚联合的抗共生效应可治疗白色念珠菌和加德纳尔菌混合性阴道炎：体外及体内研究
Ravi Jothi,Shanmugaraj Gowrishankar
Ravi Jothi
Mixed vaginitis due to bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) is the most prevalent form and presents a significant therapeutic challenge globally. Since, the administration of monotherapy leads to subsequent recurrent ...
A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017 [0.03%]
由链霉菌K22-0017产生的新型聚烯大环内酯类抗生素machidamycin生物合成基因簇及其功能分析
Yuta Awano,Ryoya Ishii,Yume Takahashi et al.
Yuta Awano et al.
A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compo...
Quinomycins with an unusual N-methyl-3-methylsulfinyl-alanine residue from a Streptomyces sp [0.03%]
一种含有非常罕见的N-甲基-3-甲亚砜丙氨酸残基的链霉菌抗生素赤黄霉素类化合物
Anqi Wang,Shasha Li,Yuanjuan Wei et al.
Anqi Wang et al.
Four new echinomycin congeners, quinomycins M-P (1-4) were isolated from the cultures of the soil-derived Streptomyces sp. CPCC205575. The planar structures were determined by comprehensive analyses of NMR and HRESIMS/MS data. The absolute ...
Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities [0.03%]
三种海洋来源曲霉菌Albifimbria verrucaria培养基中茋类成分的分离鉴定及其生物活性研究
Young-Hee Kim,Dae-Cheol Choi,Dae-Won Ki et al.
Young-Hee Kim et al.
Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chr...
Chalcomoracin promotes apoptosis and endoplasmic reticulum stress in hepatocellular carcinoma cells [0.03%]
chálicomatrin通过促进凋亡和内质网应激抑制肝细胞癌的作用机制研究
Yongliang Cui,Liqin Lan,Jiahui Lv et al.
Yongliang Cui et al.
Chalcomoracin (CMR), a Diels-Alder adduct obtained from mulberry leaves, demonstrated wide-spectrum anti-cancer activity. Herein, we aimed to explore the function of CMR and how it works in hepatocellular carcinoma (HCC). Human HCC cell lin...
Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima [0.03%]
来自担子菌Favolaschia minutissima培养物的抗疟原虫马方酸衍生物
Somporn Palasarn,Kitlada Srichomthong,Tuksaporn Thummarukcharoen et al.
Somporn Palasarn et al.
Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodeh...
The twin challenges of longevity and climate change in controlling antimicrobial resistance [0.03%]
应对长寿和气候变迁在控制抗菌素耐药性方面的双重挑战
Maryam Shafaati,Mohammadreza Salehi,Maryam Zare
Maryam Shafaati
Antimicrobial resistance (AMR) is one of the global health challenges of the 21st century that is faced with the twin threats of global climate change and greater longevity, which pose a synergistic risk to the management of AMR. Antimicrob...
Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa [0.03%]
咪康唑和苯并噻嗪可抑制铜绿假单胞菌的群体感应调节毒力作用
Amany I Gad,Amira M El-Ganiny,Ahmed G Eissa et al.
Amany I Gad et al.
Antibiotic resistance is a major health problem worldwide. Pseudomonas aeruginosa is a Gram-negative pathogen with an arsenal of virulence factors and elevated antimicrobial resistance. It is a leading cause of nosocomial infections with hi...
In vitro activity of plazomicin and other aminoglycosides against Klebsiella pneumoniae multidrug-resistant strains [0.03%]
帕拉美欣和其它氨基糖苷类对多重耐药肺炎克雷伯菌的体外活性研究
Alicja Sękowska
Alicja Sękowska
Plazomicin is a new aminoglycoside with broad-spectrum activity against multidrug-resistant strains. The aim of this study was to assess the susceptibility of the K. pneumoniae strains to plazomicin and other aminoglycosides. The activity o...