Altered myelin sphingolipid and glycerophospholipid profiles in Huntington disease [0.03%]
亨廷顿病中髓鞘鞘磷脂和甘油磷酸脂谱型的改变
Michael G Friedrich,Gabrielle R Phillips,Reuben Se Young et al.
Michael G Friedrich et al.
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT). While classically considered a disease of grey matter, recent imaging data have revealed presymptomatic abnormalit...
Psychosis in Huntington's disease: A case supporting multidisciplinary and early palliative care [0.03%]
亨廷顿病伴发精神病一例及多学科和早期姑息性护理的观点
Vy Le,Edith Sigler,Jonathan Liu et al.
Vy Le et al.
Following an abrupt medication switch from olanzapine to aripiprazole, a 61-year-old female with Huntington's disease developed psychosis that persisted despite olanzapine reinstitution. Subsequent hospitalization led to significant complic...
Prevention of appearance of severe Huntington's disease symptoms in the R6/1 mouse model by early administration of 4',5,7-trihydroxyisoflavone [0.03%]
4',5,7-三羟基异黄酮早期给药可抑制R6/1转基因小鼠亨廷顿病症状的出现
Lidia Gaffke,Estera Rintz,Magdalena Podlacha et al.
Lidia Gaffke et al.
BackgroundRecent reports indicated that 4',5,7-trihydroxyisoflavone (genistein) can improve biochemical disorders and correct behavioral disturbances in cellular and animal models of Huntington's disease (HD), acting thorough stimulation of...
Simon Okholm
Simon Okholm
Machine learning applications in Huntington's disease prognosis: A review [0.03%]
机器学习在亨廷顿舞蹈病预后中的应用：综述
Lubna M Abu Zohair,Ruben Andriessen,Noor Mahmoud et al.
Lubna M Abu Zohair et al.
Understanding the trajectory of Huntington's disease (HD) is critical for patient stratification and the development of targeted interventions. Traditionally, studies relied on age-CAG models to estimate disease onset and progression, based...
Practical recommendations for the treatment of chorea associated with Huntington's disease: An expert consensus [0.03%]
亨廷顿舞蹈症相关 chorea 治疗实用建议专家共识
Erin Furr Stimming,Jee Bang,Amy Brown et al.
Erin Furr Stimming et al.
Huntington's disease (HD) is a rare, autosomal dominant neurodegenerative disorder caused by a pathogenic CAG expansion in the huntingtin gene, classically characterized by a triad of cognitive, psychiatric, and motor symptoms. Involuntary ...
Phase-targeted auditory stimulation enhances slow-wave activity during sleep in Huntington's disease: A pilot crossover study [0.03%]
听觉刺激增强亨廷顿病患者睡眠慢波活动：一项交叉试验研究
Andreas A Braun,Jonas Buff,Nora-Hjördis Moser et al.
Andreas A Braun et al.
BackgroundSleep disturbances, including fragmentation and reduced slow-wave sleep (SWS), are common in Huntington's disease (HD). SWS contributes to synaptic homeostasis, metabolic clearance, and memory consolidation. Phase-targeted auditor...
Differential sensitivity of the MMSE and MoCA for staging and longitudinal cognitive change in Huntington's disease [0.03%]
亨廷顿病的认知损害分期和纵向认知变化中MMSE和MoCA的不同敏感性
Krisha Bagga,Ben Shifflett,Anvit Sidhu et al.
Krisha Bagga et al.
ObjectiveTo compare the sensitivity of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) for detecting cognitive change in Huntington's disease (HD) subjects stratified by baseline performance quartiles a...
Clinical implications of loss of interruption variants for diagnosis, genetic counselling, and clinical trials in Huntington's disease [0.03%]
临床意义中断变异的丧失对亨廷顿舞蹈病的诊断、遗传咨询和临床试验的影响
Hailey Findlay Black,Jessica Levesley,Chris Kay et al.
Hailey Findlay Black et al.
Age of onset in Huntington disease (HD) is influenced by cis-acting genetic variants, particularly the loss of interrupting codons in the HTT CAG and CCG repeats (CAG-CCG LOI variant). The CAG-CCG LOI variant is not detectable by current di...
Blair R Leavitt,Leslie M Thompson
Blair R Leavitt