Exploring new cardiovascular frontiers: The Italian cardiovascular research landscape [0.03%]
探索心血管新前沿：意大利心血管研究现状
Rosalinda Madonna,Vincenzo Lionetti
Rosalinda Madonna
Antagonism of the complement receptor reduces oxidative stress and matrix metalloproteinase (MMP)-2 activity in the aortas of mice with angiotensin-II-induced hypertension [0.03%]
补体受体拮抗剂对血管紧张素Ⅱ诱导的高血压小鼠主动脉氧化应激和基质金属蛋白酶-2活性的影响
Luan Victor Resque Ramos,Marcela M Blascke de Mello,Bruno Marcel Silva de Melo et al.
Luan Victor Resque Ramos et al.
Angiotensin II (Ang II) increases C3a effects through its receptors, promoting aortic oxidative stress and upregulating matrix metalloproteinase (MMP)-2. MMP-2 is implicated in hypertrophic arterial remodeling in hypertension. This study in...
Dual L/T calcium channel blocker exerts both antihypertensive and renoprotective effects in L-NAME-induced hypertension model [0.03%]
双L/T型钙离子通道阻滞剂对L-NAME诱导的高血压模型的降压和肾脏保护作用
Peter Muiruri Kamau,Yang Chen,Xiaopei Yang et al.
Peter Muiruri Kamau et al.
Renal hypertension, a common form of secondary hypertension, results from kidney disease. It arises due to the narrowing of arteries connected to the kidneys, often caused by atherosclerosis. Over time, this condition can lead to kidney fai...
Changes in circulating lipopolysaccharide and zonulin following acute myocardial infarction: The impact of smoking [0.03%]
急性心肌梗死后循环内脂多糖和zonulin的变化：吸烟的影响
Rafał Kolec,Michał Słaboszewski,Elżbieta Paszek et al.
Rafał Kolec et al.
Background: Serum lipopolysaccharide (LPS), a marker of gut dysbiosis and endotoxemia is associated with myocardial infarction (MI). We investigated factors affecting LPS changes in MI patients treated with percutaneous c...
Targeting Cis-regulatory elements for CRISPR-mediated transcriptional activation of the human MIR503HG locus [0.03%]
靶向顺式调控元件介导的人MIR503HG基因座的CRISPR转录激活
João P Monteiro,Francesca Vacante,Azzurra De Pace et al.
João P Monteiro et al.
Advances in genome annotation have revealed a striking increase in the number and complexity of non-coding RNA (ncRNA) genes, particularly multi-transcript loci that harbor long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) within the sa...
Clinical outcomes and safety of sotatercept in pulmonary arterial hypertension: A systematic review and meta-analysis of randomized controlled trials [0.03%]
索他雷塞治疗肺动脉高压的临床疗效及安全性：随机对照试验系统评价和meta分析
Mohammad Abdulelah,Chidubem Ezenna,Ancy Jenil-Franco et al.
Mohammad Abdulelah et al.
Introduction: Pulmonary arterial hypertension (PAH) remains a life-threatening condition characterized by high morbidity and mortality. However, recent therapeutic advancements have offered a paradigm shift in terms of th...
The role of histone modifications in pulmonary hypertension: From mechanisms to therapeutic targets [0.03%]
组蛋白修饰在肺动脉高压中的作用：从机制到治疗靶点
Yunhua Yang,Shaoxin Gong,Na Liang et al.
Yunhua Yang et al.
Pulmonary hypertension is a progressive vascular disease characterized by pulmonary vascular remodeling, with high mortality and poor prognosis despite advances in medical therapy. Recently, histone modification therapies for pulmonary hype...
Effects of simvastatin treatment on leptomeningeal collateral vessels: Resistance, number and diameter [0.03%]
辛伐他汀治疗对侧支循环的影响：阻力、数量和直径
Fern Williams,Kristy Martin,Thomas R Scott et al.
Fern Williams et al.
Good leptomeningeal collateral vessels (LMC) are associated with smaller lesion volume and better patient outcomes from ischaemic stroke, but their architecture varies greatly between individuals. Statins can stimulate angiogenesis and show...
Explosive discovery, surprising future: The extraordinary journey of nitroglycerin, nitroderivatives and nitric oxide [0.03%]
惊天大发现 意外的未来：硝酸甘油、硝基化合物和一氧化氮的不平凡历程
Maria Rosa Montinari,Sergio Minelli,John D Horowitz et al.
Maria Rosa Montinari et al.
For over 150 years, nitrates have been a cornerstone in the treatment of cardiovascular disease. Nitroglycerin - synthesized by Italian chemist Ascanio Sobrero in 1847 - was initially used in explosives, as the main component of dynamite, b...
Amandeep Rashid Mondal,Ashish Misra
Amandeep Rashid Mondal
Atherosclerosis is a leading cause of cardiovascular morbidity and mortality worldwide, driven by complex interactions among various plaque cell types, including endothelial cells, macrophages, and smooth muscle cells. Traditional therapies...