Role of the Elastase-2 (Ela-2)/OPN-N cascade in abdominal aortic aneurysm pathobiology: A human-to-mouse translational study [0.03%]
人源至鼠源转化研究：Ela-2/OPN-N级联反应在腹主动脉瘤发病机制中的作用
Fabiola Mestriner,Vinicius Flora Dugaich,Henrique Z Kovacs et al.
Fabiola Mestriner et al.
Abdominal aortic aneurysm (AAA) is driven by chronic inflammation and extracellular matrix (ECM) degradation. Elastase-2 (Ela-2) is a conserved chymotrypsin-like serine protease encoded by the human gene CELA2A and its murine ortholog Cela2...
Engineering functional human vasculature: iPSC-derived vascular cells and organoids for disease modeling and translation [0.03%]
基于iPSC的血管细胞和类器官在血管疾病中的作用机制及转化应用研究
Chonggui Jiang,Pan Cui,Liyan Gong
Chonggui Jiang
Human vascular function depends on tightly coordinated structural, mechanical, and cellular interactions, yet these features remain difficult to recapitulate in vitro. Induced pluripotent stem cells (iPSCs) enable efficient generation of va...
Noelia Pimentel,Aureli Luquero,Xiangjun Li et al.
Noelia Pimentel et al.
Background: Acute myocardial infarction (AMI) triggers a systemic inflammatory response that can lead to remote organ damage, including the brain. While the Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5)-mediat...
Magnetically responsive PLGA-magnetite nanoparticles for in vitro stent targeting and delivery of therapeutic agents [0.03%]
用于血管内药物释放的磁响应PLGA-磁铁矿纳米颗粒及其体外支架定位研究
Michael Kitching,Dorota Kozlowska,Roa Bashmail et al.
Michael Kitching et al.
Coronary artery disease presents as an obstruction to coronary blood flow due to the presence of a vascular lesion. Treatment options include percutaneous transluminal coronary angioplasty and the deployment of a vascular stent to keep the ...
Rheumatoid arthritis and multisite cardiac aneurysms involving the LVOT, valves, and intervalvular Fibrosa: A case-based systematic review [0.03%]
类风湿关节炎伴有多部位心脏假性动脉瘤累及主动脉瓣下、瓣膜和间叶组织：基于病例的系统性回顾
Mattia Alberti,Vitantonio Cito,Paola Capozza et al.
Mattia Alberti et al.
Cardiac involvement in rheumatoid arthritis (RA) is an uncommon but clinically relevant manifestation that may extend beyond pericardial and valvular disease to involve peri-annular and subvalvular fibrous structures. Aneurysmal and pseudoa...
The tunica adventitia: From key player in aortic aneurysm pathogenesis to promising therapeutic target [0.03%]
外膜：从主动脉瘤发病机制中的关键因素到有前景的治疗靶点
Jia-Heng He,Mi Wang,Ting Wang et al.
Jia-Heng He et al.
Aortic aneurysm is a fatal vascular disease lacking effective drug therapies. Its pathogenesis is complex, with traditional studies mainly focusing on endothelial cells in the intima and smooth muscle cells in the media. Recent studies have...
Caveolin-1 at the nexus of endothelial aging and extracellular vesicle signaling [0.03%]
Caveolin-1位于内皮衰老和细胞外囊泡信号转导的交汇点
Diego Arauna,Francisca Rodríguez,Claudio Aguayo et al.
Diego Arauna et al.
Caveolin-1 (CAV1), the principal structural protein of caveolae, is a critical regulator of endothelial homeostasis, vascular aging, and frailty in older adults. By scaffolding multiple signaling pathways and controlling endothelial nitric ...
Aspirin and fibrin clot modulation in vascular pharmacology: Fibrinogen acetylation, disease context, and translational uncertainty [0.03%]
血管药理学中阿司匹林与纤维蛋白血凝块的调节：纤维蛋白乙酰化、疾病背景及转化不确定性
Alice Nerini,Francesca Nencini,Serena Borghi et al.
Alice Nerini et al.
Fibrin clot architecture is increasingly recognized as a determinant of thrombotic phenotype and a potentially modifiable endpoint in vascular pharmacology. Aspirin is established as an antiplatelet agent through irreversible cyclooxygenase...
Interplay between Na+/K+-ATPase-dependent Src-mediated Ca2+ sensitization and BKCa channel negative feedback regulates rat mesenteric artery contraction [0.03%]
钠钾泵Src介导的钙敏感与大电导钙激活钾通道负反馈相互作用调控鼠肠系膜动脉收缩
Daniel Løgstrup Nielsen,Josef Ali Khalid,Anna Giné Martínez et al.
Daniel Løgstrup Nielsen et al.
The Na+/K+-ATPase α2 isoform regulates vascular tone by modulating Na+/Ca2+ exchange and Src kinase-dependent signaling within membrane microdomains. Inhibition of the Na+/K+-ATPase by cardiotonic steroids promotes vascular contraction thr...
Generation and validation of a Myh11Dre-Spp1Cre intersectional mouse model for lineage tracing of disease-associated smooth muscle cell states [0.03%]
用于疾病相关平滑肌细胞状态系谱追踪的Myh11Dre-Spp1Cre交联小鼠模型的构建与验证
Yuchi Tu,Nestor Ishimwe,Benedict Ofori et al.
Yuchi Tu et al.
Background: Phenotypic modulation of vascular smooth muscle cells (VSMCs) is a hallmark of vascular remodeling and cardiovascular disease. Recent lineage-tracing and single-cell transcriptomic studies have identified secr...