PPAR subtypes determine distinct modes of action of phthalate esters (PAEs) and per- and polyfluoroalkyl substances (PFAS) in disrupting human macrophage alternative activation [0.03%]
PPAR亚型决定了邻苯二甲酸酯(PAEs)和全氟和多氟烷基物质(PFAS)以不同的机制干扰人类巨噬细胞的交替激活
Zhisen Zhuang,Lijuan You,Jianbo Kong et al.
Zhisen Zhuang et al.
Phthalate esters (PAEs) and per- and polyfluoroalkyl substances (PFAS) are ubiquitous pollutants tied to metabolic and immune disorders. The peroxisome proliferator-activated receptor (PPAR) pathway has been indicated to mediate their toxic...
Transcriptomic analysis of BPA alternative chemicals in primary human mammary epithelial cells [0.03%]
双酚A替代物对原代人乳腺上皮细胞转录组的影响分析
Geronimo Matteo,Andrea Rowan-Carroll,Lauren M Bradford et al.
Geronimo Matteo et al.
Some everyday consumer products contain endocrine disruptors like bisphenol A (BPA) and its replacements. To date, most in vitro chemical screening to evaluate these compounds has been accomplished using immortalized cell lines, which diffe...
A Scalable Human Liver-on-a-Chip Platform for Predictive Safety Assessment [0.03%]
一种可预测安全评估的可扩展的人类肝脏芯片平台
Gauri Kulkarni,Lizao Chen,Jing Sang et al.
Gauri Kulkarni et al.
Non-animal methods, including advanced in-vitro approaches such as liver-on-a-chip models, hold promise for hepatotoxicity testing but remain limited in pharmaceutical and regulatory adoption due to high costs, poor scalability, low reprodu...
PM2.5 exposure exacerbates airway pyroptosis related inflammatory response in asthmatic mice by activating NLRP3 inflammasome [0.03%]
PM2.5暴露通过激活NLRP3炎症小体促进哮喘小鼠气道炎性反应
Hui Du,Zhi Liu,Lingli Ge et al.
Hui Du et al.
Background: Fine particulate matter (PM2.5)-induced airway epithelial damage plays a pivotal role in driving the development of airway inflammation. Although pyroptosis is recognized for its highly proinflammatory nature,...
Evaluating the absence of allometric scaling for hepatic microsomal Phase I and Phase II xenobiotic biotransformation among mammals [0.03%]
评价哺乳动物肝微粒体I相和II相外源性生物转化不存在全息尺度规律
Luke Ockhuijsen,Ad M J Ragas,A Jan Hendriks
Luke Ockhuijsen
Elucidating consistent patterns for xenobiotic biotransformation among mammals is challenging because of intrinsic species differences. At the organism level, pharmacokinetic rate constants are believed to scale allometrically to body weigh...
Filipa Pita,Ricardo Jorge Dinis-Oliveira,João Pedro Silva et al.
Filipa Pita et al.
Synthetic cannabinoids (SCs) represent a prominent class of new psychoactive substances (NPS), primarily consumed via inhalation methods such as smoking or vaping. Although the direct neurotoxic effects of SCs are well established, the pyro...
Mixture toxicity revisited: A translational review of experimental evidence from animal models to human health risk assessment [0.03%]
从动物模型到人类健康风险评估的混合毒性研究综述
Jose L Domingo
Jose L Domingo
This review examines research investigating how simultaneous exposure to multiple chemicals affects biological systems, highlighting deficiencies in conventional single-substance risk evaluation frameworks. Living organisms in their natural...
Prenatal diesel exhaust exposure enhances neonatal hyperoxia-induced kidney injury via oxidative stress and lipid disruption [0.03%]
孕期柴油颗粒物暴露通过氧化应激和脂质紊乱增强新生鼠氧气吸入所致肾损伤的影响研究
Sheng-Yuan Ho,Yu-Shan Chang,Hsiu-Chu Chou et al.
Sheng-Yuan Ho et al.
Prenatal exposure to diesel exhaust particles (DEP) and postnatal oxygen therapy are both clinically relevant perinatal stressors, but their combined effects on kidney development are not well characterized. Using a rat model (Sprague Dawle...
Food-borne polystyrene microplastic exposure exacerbates cognitive deficiency via enhanced neuronal synaptic damage and neuroinflammation in Alzheimer's disease [0.03%]
饮食中苯乙烯微塑料的暴露通过增强神经突触损伤和神经炎症加剧阿尔茨海默病的认知缺陷
Chong Liu,Yan Zhao,Ji-Ji Dao et al.
Chong Liu et al.
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented, yet the potential role of PS-MPs exposure in exacerbating neuronal damage and neuroinflammation in Alzheimer's disease (AD) remains unclear. Our res...
Integrative Assessment of Endocrine Disruption: From In Vitro Mechanisms to Species Extrapolation - Highlights of the German Pharma Tox Summit 2025 [0.03%]
内分泌干扰整合评估：从体外机制到物种推论——德国药物业毒理学峰会2025年亮点总结
Ute Haßmann,Lisa Gölz,René Geci et al.
Ute Haßmann et al.
Endocrine-disrupting chemicals (EDCs) are a growing focus in human and environmental risk assessment, as reflected by the new EU CLP hazard classes for endocrine disruptors. Within this context, the symposium "Cross-Species Extrapolation in...