Microplastics and nanoplastics, emerging pollutants, increased the risk of pulmonary fibrosis in vivo and in vitro: A comparative evaluation of their potential toxicity effects with different polymers and size [0.03%]
微塑料和纳米塑料(新污染物)通过体内和体外研究增加肺纤维化的风险：不同聚合物及尺寸的潜在毒性效应比较评估
Jia-Yi Dou,Sen Liu,Chen-Yu Wang et al.
Jia-Yi Dou et al.
With the increasing consumption of plastic products, microplastics (MPs) and nanoplastics (NPs), as new environmental pollution, pose a huge potential threat to human health. The different polymers and sizes of MPs and NPs are important fac...
The dysbiosis of gut microbiota attributes to the impairment of blood-brain barrier in rats triggered by cadmium [0.03%]
镉致大鼠肠道菌群失调及血脑屏障功能障碍
Tao Wang,Xinyu Huang,Le Lu et al.
Tao Wang et al.
Cadmium (Cd) is a non-biodegradable heavy metal with a long biological half-life that is detrimental to human health. As Cd can increase blood-brain barrier (BBB) permeability and disturb the gut microbiota, the relationship between the BBB...
In Silico molecular insights into CYP3A-mediated monensin detoxification across species [0.03%]
跨物种CYP3A介导的莫能菌素解毒的分子机制的计算研究
Lorenzo Pedroni,Ronette Gehring,Jean-Lou C M Dorne et al.
Lorenzo Pedroni et al.
Monensin is an ionophore antibiotic widely used in veterinary medicine, known for its marked species-specific toxicity with Equus caballus being the most sensitive species, Sus scrofa partially tolerant, while Gallus gallus is the most tole...
Induction of human cytochrome P450 enzymes activity by metabolism disrupting chemicals in the human hepatic cell line HepaRG [0.03%]
人肝癌 HepaRG 细胞系中代谢干扰化学物对人类细胞色素P450酶活性的诱导作用
Elodie Person,Nicolas J Cabaton,Laurie Urien et al.
Elodie Person et al.
Metabolism disrupting chemicals (MDCs) are a class of endocrine disrupting substances that promote metabolic changes leading to metabolic disorders in humans. Central to assessing their adverse effects is the need to better understand their...
Particulate matter extracted from human anthracotic tissues induces inflammatory markers in co-culture of lung cells and macrophages [0.03%]
从人体煤尘沉着组织中提取的颗粒物可在肺细胞和巨噬细胞共培养系统中诱导炎症标志物表达
Daniela Perroni Frias,Gabriela Lima Vieira,Juliana Smelan et al.
Daniela Perroni Frias et al.
Anthracosis, characterized by black pigmentation in the lungs and tracheobronchial tree due to inhaled carbon particles, has been linked to urban air pollution. This study analyzed the chemical composition of particulate matter extracted fr...
Copper exposure induces autophagy and angiogenesis in liver cell via ATF4 activation independent of TFEB [0.03%]
铜通过ATF4独立于TFEB激活诱导肝细胞自噬和血管生成
Meng Zhang,Yi-Ge Zhang,Yu-Tian Shi et al.
Meng Zhang et al.
Copper (Cu) pollution has become as a significant global environmental concern, leading to excessive Cu accumulation in humans and disrupting cellular homeostasis. As a key catalytic cofactor, Cu is involved in essential biological processe...
Chronic oral exposure to chlorpyrifos disrupts hepatic epigenetic regulation and induces metabolic dysfunction in mice [0.03%]
慢性口服氯氰聚酯暴露会扰乱小鼠肝脏表观遗传调控并诱导代谢紊乱
Meenakshi Mansukhani,Nirmalya Ganguli,Subeer S Majumdar et al.
Meenakshi Mansukhani et al.
Organophosphate pesticides (OPs) have found extensive use in agriculture due to their short half-lives and relatively low persistence in the environment. In recent years, a growing body of evidence has linked OPs, including chlorpyrifos (CP...
Involvement of ARTS in bisphenol A-induced apoptosis of mouse Leydig cells [0.03%]
ARTS在双酚A诱导的小鼠支持细胞凋亡中的作用机制研究
Ying Yang,Si Yang,Meijuan Zhang et al.
Ying Yang et al.
As a widely used organic chemical raw material in the world, bisphenol A (BPA) can induce apoptosis in mouse Leydig cells, yet the underlying mechanism remains insufficiently elucidated. Herein, we confirmed that BPA could induce apoptosis ...
The correlation between lung surfactant function inhibition in vitro and the effect on breathing of mice during inhalation exposure - A study of spray-formulated engine/brake cleaners and lubricating products [0.03%]
吸入暴露时肺表面活性物质功能抑制与呼吸作用影响的相关性研究——以发动机及刹车清洗剂和润滑产品气溶胶配方为例
Jorid B Sørli,Sreyoshee Roy Sengupta,Niels Hadrup
Jorid B Sørli
Moving parts in motors require maintenance, both lubrication for smooth operation and de-greasing for cleaning and repair. Since these motor parts are hard to reach, cleaning and lubrication products are often applied by spraying. However, ...
2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) triggers Z-DNA-binding protein 1(ZBP1)- (Receptor-interacting serine/threonine-protein kinase 3) RIP3 mediated programmed necrosis in hepatic cells by inducing mitochondrial left-handed helix (Z-DNA) release [0.03%]
2-乙基己基-2,3,4,5-四溴苯甲酸酯(TBB)通过诱导线粒体左手螺旋(Z-DNA)释放触发肝细胞中Z-DNA结合蛋白1（RIP3）介导的程序性坏死
Meng Yu,Li Jinchao,Liu Jinlai et al.
Meng Yu et al.
Traditional Polybrominated Diphenyl Ethers (PBDEs) have been gradually banned due to their significant health impacts. As a substitute, the novel brominated flame retardant 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) has been extensively ...