Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression [0.03%]
砷化物通过干扰硒代谢并降低GPx4表达来使细胞对铁死亡敏感
Hayato Takashima,Reiko Makino,Hiroki Taguchi et al.
Hayato Takashima et al.
Arsenic (As), an environmental toxicant commonly found in groundwater, exerts its toxic effects primarily through oxidative stress. Selenium (Se) plays a crucial role in counteracting oxidative stress by promoting the synthesis of Se-contai...
Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid models [0.03%]
持久性有机污染物：神经毒性机制及其类器官模型的启示
Ziyu Ji,Liqun Chen,Dong Ming
Ziyu Ji
Persistent Organic Pollutants (POPs) pose significant global environmental health risks due to their persistence, bioaccumulation, and long-range transport. Exposure to POPs has been linked to a range of neurological disorders, including co...
Cigarette smoke exposure disrupts the blood-testis barrier and negatively impacts reproductive capacity in mice [0.03%]
烟草烟雾暴露破坏小鼠血睾屏障并影响其生殖能力
Yuan Zhong,Xueyu Wei,Zimangul Yasin et al.
Yuan Zhong et al.
Maintaining normal testicular structure and function is closely related to the blood-testis barrier (BTB). Meanwhile, cigarette smoke extract (CSE) affects testicular function. However, whether CSE mediates BTB damage and the underlying mec...
Could cannabigerol protect against neuroinflammation? Insights from an in vitro microglial study [0.03%]
大麻萜酚能保护神经不受炎症影响吗？一项体外小胶质细胞研究的启示
Júlia Maiara Dos Santos,Amanda Kolinski Machado,Djenifer Leticia Ulrich Bick et al.
Júlia Maiara Dos Santos et al.
Cannabigerol (CBG), a non-psychotropic cannabinoid from Cannabis sativa, has been investigated for its anti-inflammatory potential. However, its toxicological profile and the mechanisms underlying its effects are still poorly understood. Th...
PM2.5 induces cardiac defects by triggering endoplasmic reticulum stress mediated through the impairment of SIRT6 deacetylase activity [0.03%]
PM2.5通过抑制SIRT6脱乙酰酶活性诱导内质网应激从而导致心脏缺陷
Jianhui Liu,Yuan Wang,Shaofei Su et al.
Jianhui Liu et al.
A growing body of research suggests that maternal exposure to fine particulate matter (PM2.5) is linked to congenital heart disease in the offspring. Endoplasmic reticulum stress (ERS) has been established as a cause of the cardiac developm...
The regulatory roles of BMAL1 in TDCIPP-induced autophagy and apoptosis in HT22 cells [0.03%]
BMAL1在TDCIPP诱导的HT22细胞自噬和凋亡中的作用机制研究
Yu Liu,Ruoxuan Liang,Benhong Xu
Yu Liu
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), a common organophosphate flame retardant, is extensively used in various consumer products and has emerged as an environmental pollutant. Recent studies have documented the neurotoxic effects ...
Corrigendum to "Titanium nanoparticles provoke ferritinophagy-mediated ferroptosis via inhibition of the Nrf2-HO-1 signaling pathway in osteocytes'' [Toxicology 519 (January) (2026) 154324, doi:10.1016/j.tox.2025.154324] [0.03%]
关于“钛纳米粒子通过抑制Nrf2-HO-1信号通路诱发成骨细胞中铁蛋白溶酶体介导的铁死亡”的勘误修正[毒理学第519卷(2026年1月)154324页,doi:10.1016/j.tox.2025.154324]
Ruirong Zhu,Yun Zhang,Yuting Wang et al.
Ruirong Zhu et al.
Published Erratum
Toxicology. 2026 Jan 12:154399. DOI:10.1016/j.tox.2026.154399 2026
PFHxS exposure causes osteoarthritis through the innate immune signaling pathway mediated by lipid peroxidation [0.03%]
PFHxS通过脂质过氧化介导的固有免疫信号通路导致骨关节炎
Xicong Chen,Huiliang Zeng,Guocai Chen et al.
Xicong Chen et al.
PFHxS have been widely used and detected in the environment. The toxicological effects of PFHxS exposure on cartilage tissues and cells are not fully clear. The objective of this work was to study the toxicological effects of PFHxS on carti...
IMPACT OF PM2.5 ON CARDIORESPIRATORY MORTALITY: A STUDY IN THE CAPITALS OF BRAZILIAN AMAZON RAINFOREST [0.03%]
巴西亚马孙雨林首府城市中PM2.5对心肺疾病死亡率的影响研究
Gustavo de Oliveira Silveira,Rodrigo de Lima Brum,Ronan Adler Tavella et al.
Gustavo de Oliveira Silveira et al.
Wildfire-related air pollution represents an escalating health threat in the Brazilian Amazon, where fine particulate matter (PM2.5) concentrations frequently exceed safe levels (5µg/m-3). This study quantified long-term PM2.5 exposure and...
In vivo and in vitro toxicokinetics including metabolism, isozyme mapping, and monoamine oxidase inhibition of three (2-aminopropyl)benzo[b]thiophene (APBT) psychedelics [0.03%]
三种(2-氨基丙基)苯并噻吩(APBT)类致幻剂的体内和体外毒代动力学、代谢、同工酶图谱及单胺氧化酶抑制作用研究
Lea Wagmann,Simon D Brandt,Pierce V Kavanagh et al.
Lea Wagmann et al.
3-(2-Aminopropyl)benzo[b]thiophene (3-APBT), 5-APBT, and 6-APBT are recently identified psychedelics and entactogens that activate serotonin 2 receptor subtypes and lead to a head-twitch response in mice. The present study characterized the...