Co-exposure to Fluoride and Arsenic induces Endoplasmic Reticulum Stress in C2C12 Myoblasts and MC3T3 Preosteoblasts [0.03%]
氟和砷共暴露诱导C2C12肌母细胞和MC3T3成骨前体细胞内质网应激
Deepika Bhat K,Joel Rimson Pinto,Apoorva H Nagendra et al.
Deepika Bhat K et al.
Environmental exposure to fluoride and arsenic is a major public health concern in many regions worldwide. Although both toxicants are known to impair skeletal development, the cellular mechanisms underlying their combined effects on skelet...
Behavioral effects of chronic PFHxA exposure on spatial memory function [0.03%]
慢性PFHxA暴露对空间记忆功能的行为影响研究
Dong Hun Lee,BaDa Cho,Jieun Seo et al.
Dong Hun Lee et al.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in human biological samples. As regulatory restrictions on long-chain PFAS such as PFOA and PFOS have increased, short-chain alternatives, ...
Lead triggers hepatocyte ferroptosis through coordinated mitochondrial injury and ER stress-mediated autophagic degradation of GPX4 [0.03%]
铅通过协同作用的线粒体损伤和内质网应激介导的GPX4自噬降解触发肝细胞铁死亡
Xi Qiu,Wenjie Yang,Xuejun Wang et al.
Xi Qiu et al.
Lead (Pb) is one of the major heavy metal pollutants that induces multi-organ toxicity. Liver is the primary target of Pb, the exposure of which induces hepatotoxicity by triggering hepatocyte cell death. Ferroptosis, a novel iron-dependent...
Mechanistic insights into deoxynivalenol-induced cytotoxicity in an SH-SY5Y 3D spheroid model [0.03%]
脱氧雪腐镰刀菌烯醇诱导的SH-SY5Y三维球状模型细胞毒性作用机制研究
M Sánchez,Zingales th,J Tolosa et al.
M Sánchez et al.
Deoxynivalenol (DON) is a trichothecene mycotoxin frequently detected in cereal-derived foods and animal feed. Exposure to DON has been associated with a variety of toxic effects, including neurotoxicity. Three-dimensional (3D) cell culture...
Exploring Chemically-Induced Oxidative Stress: A Comparative Study of Zebrafish Embryos and Maturated HepG2 Cells [0.03%]
化学诱导的氧化应激的探究——斑马鱼胚胎与HepG2细胞系的比较研究
Christina H J Veltman,Edwin P Zwart,Caroline Versluis et al.
Christina H J Veltman et al.
To advance next-generation risk assessment of non-genotoxic carcinogens, robust mechanism-based assays are essential. A recognized mode of action for non-genotoxic carcinogens is induction of oxidative stress leading to regenerative prolife...
Isopropoxate Exerts Neurotoxicity by Crossing the Blood-Brain Barrier and Mediating through Inflammation-Neurotransmitter Signaling Pathways [0.03%]
异丙氧基通过血脑屏障转运及炎症-神经递质信号通路介导的神经毒性作用
Renjuan Cao,Zien Chen,Jihong Cai et al.
Renjuan Cao et al.
Isopropoxate (IPPO), an emerging imidazole ester-type new psychoactive substance, poses potential risks to public health and the environment, yet its neurotoxic mechanisms remain poorly understood. In this study, 8-week-old C57BL/6J mice we...
CD44-targeting small-molecule inhibitors restore hyaluronan homeostasis and reduce profibrotic matrix remodeling in vocal fold fibroblasts exposed to cigarette smoke extract [0.03%]
CD44靶向的小分子抑制剂可恢复声带成纤维细胞中香烟烟雾提取物暴露引起的透明质酸稳态并减少促纤维化基质重塑
Kaustuv Basu,Luc Mongeau
Kaustuv Basu
Vocal fold scarring (VFS) is a debilitating fibrotic disorder lacking molecular biomarkers for early detection or for monitoring toxicant-induced injury. Cigarette smoke toxicity (CST), a major environmental driver of vocal fold fibrosis, d...
Are microcystin-LR and cylindrospermopsin neurotoxic for human cells? An in vitro study on induced pluripotent stem cells-derived models [0.03%]
微囊藻毒素-LR和鱼腥藻素是否会对人体细胞产生神经毒性？诱导多能干细胞系模型的体外研究
Antonio Casas-Rodríguez,David Pamies,David Lopez-Rodriguez et al.
Antonio Casas-Rodríguez et al.
Microcystin LR (MC LR) and cylindrospermopsin (CYN) are cyanobacterial toxins commonly detected during harmful algal blooms in freshwater systems. Their increasing occurrence raises concerns about water quality and potential risks to human ...
Fate, toxicology and Organ-on-a-chip methodology of nanoplastics in human body [0.03%]
纳米塑料在人体内的命运、毒理学及器官芯片研究方法
Yan Wang,Fan Lü,Jingjing Fang et al.
Yan Wang et al.
Nanoplastics (NPs) can cross the human biological barriers, enter the bloodstream, and accumulate in vital organs due to their unique physical and chemical properties. This review provides a detailed explanation of the mechanisms by which N...
Deoxynivalenol induces macrophage extracellular trap formation via the PER2-c-Myc-ROS Axis [0.03%]
脱氧雪腐镰刀菌烯醇通过PER2-c-MYC-ROS轴诱导巨噬细胞胞外陷阱形成
Baimei Zhao,Shiqing Tan,Junyao Li et al.
Baimei Zhao et al.
Deoxynivalenol (DON), a Fusarium-derived mycotoxin, disrupts immune homeostasis and induces immunotoxicity. Macrophage extracellular traps (METs) are key effectors in innate immunity and inflammation, yet whether DON triggers METs formation...